Anticancer activity of dinuclear gallium(III) carboxylate complexes

Kaluđerović, Milena R.; Gómez‐Ruiz, Santiago; Gallego, Beatriz; Hey‐Hawkins, Evamarie; Paschke, Ralf; Kaluđerović, Goran N.

doi:10.1016/j.ejmech.2009.10.038

Cited by 47 publications

(40 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, a more in depth study of compound 21 against HeLa and Fem-x cell showed the induction of an apoptotic cell death [37]. In another study, our group prepared tetraorganotin(IV) compounds containing cyclopentadienyl ligands (22)(23)(24)(25) which were prepared by the simple transmetallation reaction of lithium cyclopentadienide derivatives with SnPh 3 Cl (Scheme 3) [38]. All the compounds were isolated as single isomers even though the position of the double bonds makes possible the formation of a mixture of positional isomers.…”

Section: Tin-based Metallodrugsmentioning

confidence: 99%

“…All the compounds showed a dose-dependent antiproliferative effect toward cell lines and presented lower IC 50 Tin(IV) complexes (22)(23)(24)(25) were tested in vitro against 8505C, A253, A549, A2780, and DLD-1 cell lines by using the sulforhodamine-B microculture colorimetric assay (Table 3) In a subsequent study, a series of rare ionic triphenyltin(IV) chloride carboxylate complexes (26-28, Figure 8) was synthesized and tested against 8505C, A253, A549, A2780, and DLD-1 cell lines (Table 3). All the ionic tin(IV) compounds presented anticancer activities up to 50 times more active than those of cisplatin (for example in DLD-1 complex 26 has an IC50 value of 0.103 µM compared to that of cisplatin of 5.14 µM).…”

Section: Tin-based Metallodrugsmentioning

confidence: 99%

“…The cytotoxic activity of all the studied compounds was much higher than that presented by gallium(III) nitrate. From all the reported complexes, 7 (containing the benzodioxane carboxylate ligand) presented the highest cytotoxicity against A253 cells with the lowest IC50 value of 6.6 ± 0.2 µM [25].…”

Section: Gallium-based Metallodrugsmentioning

confidence: 99%

“…Tin(IV) complexes (22)(23)(24)(25) were tested in vitro against 8505C, A253, A549, A2780, and DLD-1 cell lines by using the sulforhodamine-B microculture colorimetric assay (Table 3) [39]. All the compounds showed a dose-dependent antiproliferative effect toward cell lines and presented lower IC 50 Tin(IV) complexes (22)(23)(24)(25) were tested in vitro against 8505C, A253, A549, A2780, and DLD-1 cell lines by using the sulforhodamine-B microculture colorimetric assay (Table 3) In a subsequent study, a series of rare ionic triphenyltin(IV) chloride carboxylate complexes (26-28, Figure 8) was synthesized and tested against 8505C, A253, A549, A2780, and DLD-1 cell lines (Table 3).…”

Section: Tin-based Metallodrugsmentioning

confidence: 99%

See 3 more Smart Citations

Anticancer Applications and Recent Investigations of Metallodrugs Based on Gallium, Tin and Titanium

2017

Self Cite

View full text Add to dashboard Cite

Abstract:For more than 100 years metal complexes have been extensively used in therapy and since the discovery of cisplatin the research in this field has expanded exponentially. The scientific community is always in search of new alternatives to platinum compounds and a wide variety of metallodrugs based on other metals have been reported with excellent therapeutic results. This short review focuses on the work that our research group has carried out since 2007 in collaboration with others and centers on the preparation of organogallium(III) compounds, organotin(IV) derivatives, and titanocene(IV) complexes together with the study of their cytotoxic anticancer properties.

show abstract

Section: Tin-based Metallodrugsmentioning

confidence: 99%

Section: Tin-based Metallodrugsmentioning

confidence: 99%

Section: Gallium-based Metallodrugsmentioning

confidence: 99%

Section: Tin-based Metallodrugsmentioning

confidence: 99%

See 2 more Smart Citations

Anticancer Applications and Recent Investigations of Metallodrugs Based on Gallium, Tin and Titanium

2017

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is worth mentioning that metal complexes of gallium(III), tested on the same 8505c cell lines, have recently shown IC 50 values of more than 10 times higher [63,70].…”

Section: Biological Activitymentioning

confidence: 99%

(Dipyrido[3,2-a:2′,3′-c]phenazine)(glycinato)copper(II) perchlorate: A novel DNA-intercalator with anti-proliferative activity against thyroid cancer cell lines

Terenzi

Tomasello

Spinello

et al. 2012

Journal of Inorganic Biochemistry

View full text Add to dashboard Cite

This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited. A novel copper(II) heteroleptic complex of dipyrido[3,2-a:2′,3′-c]phenazine (dppz) and glycinato (gly) as chelating ancillary ligand, [Cu(dppz)(gly)]ClO 4 (1), was synthesized and characterized. X-ray crystallography revealed that the coordination geometry of the cationic [Cu(dppz)(gly)]+ unit is hexacoordinated and shows a distorted octahedral coordination geometry in the solid state, with the N,N and N,O chelating atoms of dppz and glycinato, respectively, in the square plane and in which the planar units are connected in a monodimensional polymeric array by the apical copper coordination of the second carboxylic oxygen atom. Biological assays showed that 1 exhibits a remarkable anti-proliferative activity against the two human anaplastic thyroid cancer cell lines 8505c (BrafV600E/V600E) and SW1736 (BrafWT/V600E), in a dose-and time-dependent manner. In details, the IC 50 after 48 h of drug exposure was 2.86±0.54 μM for SW1736 and 1.05±0.48 μM for 8505c. On the other hand, the IC 50 shown by cis-diamminedichloroplatinum(II) (cisplatin) against the same cell lines was 2.50±0.40 μM and 6.03±0.78 μM, respectively. Optical microscopy observations, after 48 h of treatment, showed morphological cell changes typical of apoptosis, confirmed by DNA ladder assays. DNA interaction studies, performed by UV absorption spectrophotometry, circular dichroism and viscosimetry, clearly showed that [Cu(dppz)(gly)]ClO 4 is a DNA-intercalator, with a DNA-binding constant, K b , of 2.1×10 6 M −1, suggesting that the mechanism of the cytotoxic activity can be related to its DNA-binding.

show abstract

Gallium: Inorganic Chemistry

Banger

2015

Encyclopedia of Inorganic and Bioinorganic Chemistry

View full text Add to dashboard Cite

This article is based on the original article written by Barron et al ., which provides an overview of the inorganic chemistry of gallium and its compounds. While the structure has remained the same, the sections have been updated to include areas of current studies in this field. In addition, the use of various Ga‐related alloys as either binary or ternary semiconducting material for bulk, thin film, and nanotechnology is reported. The chemistry of Ga inorganic and coordination derivatives is also reviewed and discussed.

show abstract

Anticancer activity of dinuclear gallium(III) carboxylate complexes

Cited by 47 publications

References 49 publications

Anticancer Applications and Recent Investigations of Metallodrugs Based on Gallium, Tin and Titanium

Anticancer Applications and Recent Investigations of Metallodrugs Based on Gallium, Tin and Titanium

(Dipyrido[3,2-a:2′,3′-c]phenazine)(glycinato)copper(II) perchlorate: A novel DNA-intercalator with anti-proliferative activity against thyroid cancer cell lines

Gallium: Inorganic Chemistry

Contact Info

Product

Resources

About