Anticancer Activity of Essential Oils: Targeting of Protein Networks in Cancer Cells

Aras, Aliye; Iqbal, Muhammad; Naqvi, Syed Kamran-ul-Hassan; Gerçek, Yusuf Can; Boztaş, Kadir; Gasparri, Maria Luisa; Shatynska-Mytsyk, Iryna; Fayyaz, Sundas; Farooqı, Ammad Ahmad

doi:10.7314/apjcp.2014.15.19.8047

Cited by 10 publications

(8 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Owing to the possession of antibacterial and anti-cancer activities, plant essential oil has become the focus of phytomedicine research 40 , 41 and drug delivery system formulation development. 42 In recent times, lavender is widely cultivated around the world, and L angustifolia is the most common species.…”

Section: Discussionmentioning

confidence: 99%

“…1,37,38 The effects of green tea polyphenols for prostate cancer prevention and treatment have been studied in epidemiological, preclinical, and early clinical investigations. 39 Owing to the possession of antibacterial and anti-cancer activities, plant essential oil has become the focus of phytomedicine research 40,41 and drug delivery system formulation development. 42 In recent times, lavender is widely cultivated around the world, and L angustifolia is the most common species.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

In Vitro and In Vivo Efficacy Studies of Lavender angustifolia Essential Oil and Its Active Constituents on the Proliferation of Human Prostate Cancer

et al. 2016

View full text Add to dashboard Cite

Lavandula angustifolia is the most widely cultivated Lavandula species. The extraction of its flower and leaves has been used as herbal medicine. In this study, the in vitro antitumor activities were tested on human prostate cancer PC-3 and DU145 cell lines. Flow cytometry technology was applied to study apoptosis induction and cell cycle arrest. The PC-3 cell line was used to establish subcutaneous xenograft tumors in nude mice. Paraffin sections from xenograft tumor specimens were used in the TUNEL (terminal deocynucleotide transferase dUTP nick end labeling) assay and an immunohistochemistry assay to detect cell proliferation markers Ki67 and PCNA. Lavender essential oil, linalool, and linalyl acetate showed stronger inhibitory effect on PC-3 cells than on DU145 cells. The apoptotic cell populations observed in PC-3 cells treated with lavender essential oil, linalool, and linalyl acetate were 74.76%, 67.11%, and 56.14%, respectively. The PC-3 cells were mainly arrested in the G2/M phase. In the xenograft model with PC-3 cell transplantation, essential oil and linalool significantly suppressed tumor growth. The immunosignals of Ki67 and PCNA in the essential oil, linalool, and linalyl acetate treatment groups were significantly lower than that of the control group in xenograft tumor sections. The TUNEL assay indicated that each of the 3 phytochemicals significantly induced apoptosis compared to the control group. This study provides novel insight and evidence on the antiproliferative effect of L angustifolia essential oil and its major constituents on human prostate cancer. The antitumor effect was associated with cell proliferation inhibition and apoptosis induction in xenograft tumors.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

In Vitro and In Vivo Efficacy Studies of Lavender angustifolia Essential Oil and Its Active Constituents on the Proliferation of Human Prostate Cancer

et al. 2016

View full text Add to dashboard Cite

show abstract

“…ducts and vittae) occurring in the vegetative and reproductive organs. [4] Recently, these essential oils are gaining an increasing interest as effective and eco-friendly biopesticides, [5 -7] as well as antiprotozoal, [2] [8] antimicrobial, [9] and anticancer [10] [11] agents. Among the major constituents of the Apiaceae essential oils, monoterpenes, sesquiterpenes, and phenylpropanoids are the most common.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Essential Oils from Eryngium campestre and Eryngium amethystinum (Apiaceae) Growing in Central Italy

Cianfaglione

Blomme

Quassinti

et al. 2017

Chemistry & Biodiversity

View full text Add to dashboard Cite

Eryngium campestre and E. amethystinum are thorny herbs belonging to the Apiaceae family and spontaneously growing in stony pastures and dry meadows, preferentially on calcareous substrates. In the Mediterranean countries, these plants have been used as a food or traditional remedies to treat various ailments. In the present work, we have analyzed the chemical composition of the essential oils distilled from the aerial parts by GC-FID and GC/MS, and evaluated their cytotoxic effects on a panel of human cancer cells, namely A375 (human malignant melanoma), MDA-MB 231 cells (human breast adenocarcinoma), and HCT116 cells (human colon carcinoma), by the MTT assay. Furthermore, the Eryngium essential oils were evaluated for antioxidant and acetylcholinesterase (AChE) activities. The two essential oils were rich in sesquiterpene hydrocarbons, with germacrene D as the major compound, accompanied by allo-aromadendrene, β-elemene, spathulenol, and ledol. They turned out to be highly cytotoxic on the tumor cells, with IC values (1.65 - 5.32 and 1.57 - 2.99 μg/ml for E. amethystinum and E. campestre, respectively) comparable or close to those of the anticancer drug cisplatin. The E. amethystinum essential oil exhibited a moderate antioxidant activity, whereas that of E. campestre a weak AChE inhibition.

show abstract

“…[4] However, many phytochemicals including essential plant oils have shown their benefits in various cancer cell lines. [25] The authors observed MN frequencies in exfoliated buccal cells in normal mucosa, precancerous lesions and squamous cell carcinoma of Indian participants and concluded that the MN frequency may be a marker of epithelial carcinogenic progression. [26] Here, we have focused on the MN formation, apoptosis frequency and detection of chromosomal abnormalities and observed in various cases of premalignant and malignant stages of OSCC and their association with various risk factors in participants of West Bengal, which will help us to analyze the extent of carcinogenic invasion and compare these with the control groups.…”

Section: Discussionmentioning

confidence: 99%

Cytogenetic and micronuclei study of human papillomavirus-related oral squamous cell carcinoma

Pal

Raychowdhury

Basu

et al. 2018

J Oral Maxillofac Pathol

View full text Add to dashboard Cite

Background: The association of human papilloma viral infection in oral squamous cell carcinoma is well studied in the Western countries, but its correlation with DNA damage in the form of micronuclei (MN) formation, ceased apoptosis or presence of chromosomal abnormalities has not yet been studied. Aim: The aim of this study is to find any possible correlation between human papillomavirus (HPV) infection and cytogenetic damage in the oral malignant and premalignant population of West Bengal. Settings and Design: A total of 104 malignant and 103 premalignant cases were selected along with 200 controls. Methods: The buccal smear samples were Pap stained for the detection of MN, apoptosis frequency and koilocytes. The buccal swab samples were processed for DNA extraction followed by polymerase chain reaction for the detection of HPV DNA. The peripheral venous blood samples were processed for the detection of any chromosomal abnormality, by the method of human leukocyte culture followed by Giemsa staining. Statistical Analysis Used: Correlation analysis using GraphPad Prism software was used in this study. Results: About 34.6%, 42.3% and 6.73% of malignant and 6.79%, 3.88% and 20.38% of premalignant cases showed the presence of HPV DNA, koilocytes and apoptosis, respectively. The difference between the MN frequencies of premalignant and malignant oral lesions with the control group is significant with respect to various risk factors ( P < 0.05). One percentage of malignant cases showed the presence of chromosomal break. Conclusion: A considerable percentage of malignant cases showing the presence of koilocytes and viral DNA may indicate the effect of HPV infection leading to the malignancy, which can be correlated with the MN and apoptosis frequency.

show abstract

Anticancer Activity of Essential Oils: Targeting of Protein Networks in Cancer Cells

Cited by 10 publications

References 31 publications

In Vitro and In Vivo Efficacy Studies of Lavender angustifolia Essential Oil and Its Active Constituents on the Proliferation of Human Prostate Cancer

In Vitro and In Vivo Efficacy Studies of Lavender angustifolia Essential Oil and Its Active Constituents on the Proliferation of Human Prostate Cancer

Cytotoxic Essential Oils from Eryngium campestre and Eryngium amethystinum (Apiaceae) Growing in Central Italy

Cytogenetic and micronuclei study of human papillomavirus-related oral squamous cell carcinoma

Contact Info

Product

Resources

About