Anticancer Activity of Fascaplysin against Lung Cancer Cell and Small Cell Lung Cancer Circulating Tumor Cell Lines

Rath, Barbara H.; Hochmair, Maximilian; Plangger, Adelina; Hamilton, Gerhard

doi:10.3390/md16100383

Cited by 37 publications

(30 citation statements)

References 47 publications

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“…In addition fascaplysin also induces autophagy in HL-60 cells and attenuates PI3K/AKT/mTOR signalling [41]. More recently, Rath et al [42] demonstrated that fascaplysin exerts an anti-proliferative and pro-apoptotic effect in lung cancer and small-cell lung cancer circulating tumour cell lines by involving AKT/PKB and adenosine monophosphate-activated protein kinase (AMPK) pathways.…”

Section: Marine-derived Compounds: Inductors Of Apoptosismentioning

confidence: 99%

New Drugs from the Sea: Pro-Apoptotic Activity of Sponges and Algae Derived Compounds

2019

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Natural compounds derived from marine organisms exhibit a wide variety of biological activities. Over the last decades, a great interest has been focused on the anti-tumour role of sponges and algae that constitute the major source of these bioactive metabolites. A substantial number of chemically different structures from different species have demonstrated inhibition of tumour growth and progression by inducing apoptosis in several types of human cancer. The molecular mechanisms by which marine natural products activate apoptosis mainly include (1) a dysregulation of the mitochondrial pathway; (2) the activation of caspases; and/or (3) increase of death signals through transmembrane death receptors. This great variety of mechanisms of action may help to overcome the multitude of resistances exhibited by different tumour specimens. Therefore, products from marine organisms and their synthetic derivates might represent promising sources for new anticancer drugs, both as single agents or as co-adjuvants with other chemotherapeutics. This review will focus on some selected bioactive molecules from sponges and algae with pro-apoptotic potential in tumour cells.

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Section: Marine-derived Compounds: Inductors Of Apoptosismentioning

confidence: 99%

New Drugs from the Sea: Pro-Apoptotic Activity of Sponges and Algae Derived Compounds

2019

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“…In HCT116 WT cells, LSSE induced apoptosis via modulation of p53 and in HCT116 p53 KO cells, LSSE induced autophagy via decreasig mTOR and Bcl-2 (13). A bis-indole, fascaplysin, was isolated from a marine sponge and it demonstrated antineoplastic response via downstream regulation of CDK4 signaling pathway and modulation of phosphoproteins in human lung cancer cell lines (A549) (133).…”

Section: Marine Products That Fight Cancermentioning

confidence: 99%

Prevention and Treatment of Cancer with Alternative Anticancer Approach: Current Scenario

Roy¹,

Mandal²,

Ramadan³

2020

Egypt. J. Chem.

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C ANCER is a serious concern right away which severely affects the mankind. Recently, the centre of interest of pharmaceutical industry is to develop newer drug molecules with very less or no toxicity to prevent and cure this life-threatening disease. Nature is the origin of remedies for human. Natural therapeutic agents brought a great change in recent drug market, as these are simple, safer, eco-friendly, low-cost, and less toxic in respect to commonly using drugs. Natural anticancer agents are selective in their functions and targetfully act on tumor cells without having any effect on normal cells. Cancer is a complex phenomenon which requires many signaling pathways. Natural therapeutic agents are the appropriate candidates to develop anticancer drug on account of their pleiotropic actions on target events with diverse manners. In this review we have collected a basket, flooded with latest information (2010-2020) on prevention and treatment of cancer with several products from nature, such as phytohemical (artemisinin, parthenolide, thapsigargin, curcumin, resveratrol, quercetin, coumarin, calcitriol, capsaicin, fisetin, evodiamine, boswellic acid, betulinic acid, deoxyelephantopin), plant (Rosmarinus officinalis L., Aloe vera, Olea europaea), functional foods (pomegranate, mango, amla, garlic, ginger, broccoli, mushroom, green tea, coffee, honey), textile and marine product based on their mechanism of action.

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“…Marine natural products are sources of compounds that have demonstrated a plethora of biological activities, in both preclinical and clinical research, such as antifungal (D'auria et al, 2007), anticoagulant (Jung et al, 2007), antibacterial (Horie et al, 2008), anti-inflammatory (Chao et al, 2008), immunomodulatory (Yamada et al, 2007;Courtois et al, 2008), antiviral (Artan et al, 2008) and anticancer (Malyarenko et al, 2018;Rath et al, 2018). Additionally, spasmolytic activity has been described for the brown alga Dictyota pulchella (Queiroz et al, 2011), the green alga Hydrodictyon reticulatum (Gutierrez et al, 2012), and caulerpina, an alkaloid isolated from algae of Caulerpa genus (Cavalcante-Silva et al, 2013;Cavalcante-Silva et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Oceanapia magna Sponge Presents Dual Effect on the Gastrointestinal Motility of Rodents: In Vitro and In Vivo Assays

et al. 2020

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Oceanapia magna Santos-Neto, Nascimento, Cavalcanti and Pinheiro sponges are distributed across tropical worldwide seas. Some studies of marine products have shown interesting activities in smooth muscle models. Hence, we assessed the effect of the ethanolic extract of Oceanapia magna. (OC-EtOH) on acute toxicity and gastrointestinal motility (in vitro and in vivo) in rodent models. On guinea pig ileum, OC-EtOH induced a concentration dependent contraction on basal tonus, which was not inhibited by atropine, but in the presence of pyrilamine or verapamil, the effect was antagonized. Contrastingly, on KCl- or histamine-induced contractions, OC-EtOH presented a transient contraction followed by a concentration-dependent relaxation. Moreover, OC-EtOH presented a relaxant profile on cumulative curves to CaCl2 and tonic contraction induced by S-(-)-BayK8644, through Cav blockade. The acute toxicity assay showed that OC-EtOH (2,000 mg/kg, p.o.) did not present any sign of toxicity in female mice. Additionally, OC-EtOH presented antidiarrheal effect in mice, increased the intestinal normal transit and reduced the castor oil-induced intestinal transit. Thus, OC-EtOH presented a dual effect on guinea pig ileum promoting contraction through activation of H1 and CaV, and relaxation through CaV blockade, besides the effect on upper gastrointestinal transit in mice, showing a potential medicinal use of this sponge in intestinal diseases such as diarrhea.

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Anticancer Activity of Fascaplysin against Lung Cancer Cell and Small Cell Lung Cancer Circulating Tumor Cell Lines

Cited by 37 publications

References 47 publications

New Drugs from the Sea: Pro-Apoptotic Activity of Sponges and Algae Derived Compounds

New Drugs from the Sea: Pro-Apoptotic Activity of Sponges and Algae Derived Compounds

Prevention and Treatment of Cancer with Alternative Anticancer Approach: Current Scenario

Oceanapia magna Sponge Presents Dual Effect on the Gastrointestinal Motility of Rodents: In Vitro and In Vivo Assays

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