Anticancer activity of graphene oxide-reduced graphene oxide-silver nanoparticle composites

Kavinkumar, T.; Varunkumar, Krishnamoorthy; Ravikumar, Vasulinga T.; Manivannan, S.

doi:10.1016/j.jcis.2017.07.002

Cited by 87 publications

(30 citation statements)

References 26 publications

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“…On the other hand, the anticancer activity of GO, AgNPs, and GO-AgNP nanohybrids against different cancer cells has been reported [94,95]. Silver nanoparticle-decorated graphene oxide shows enhanced anticancer activity compared to GO [96]. Therefore, GO-AgNP nanohybrids could have potential applications in theranostics for cancer [97,98].…”

Section: Antimicrobial Activity Assessmentmentioning

confidence: 99%

Graphene Oxide–Silver Nanoparticle Nanohybrids: Synthesis, Characterization, and Antimicrobial Properties

et al. 2020

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Drug resistance of pathogenic microorganisms has become a global public health problem, which has prompted the development of new materials with antimicrobial properties. In this context, antimicrobial nanohybrids are an alternative due to their synergistic properties. In this study, we used an environmentally friendly one-step approach to synthesize graphene oxide (GO) decorated with silver nanoparticles (GO–AgNPs). By this process, spherical AgNPs of average size less than 4 nm homogeneously distributed on the surface of the partially reduced GO can be generated in the absence of any stabilizing agent, only with ascorbic acid (L-AA) as a reducing agent and AgNO3 as a metal precursor. The size of the AgNPs can be controlled by the AgNO3 concentration and temperature. Smaller AgNPs are obtained at lower concentrations of the silver precursor and lower temperatures. The antimicrobial properties of nanohybrids against Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa, Gram-positive Staphylococcus aureus, and the yeast Candida albicans were found to be concentration- and time-dependent. C. albicans and S. aureus showed the highest susceptibility to GO–AgNPs. These nanohybrids can be used as nanofillers in polymer nanocomposites to develop materials with antimicrobial activity for applications in different areas, and another potential application could be cancer therapeutic agents.

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Section: Antimicrobial Activity Assessmentmentioning

confidence: 99%

Graphene Oxide–Silver Nanoparticle Nanohybrids: Synthesis, Characterization, and Antimicrobial Properties

et al. 2020

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“…The XRD pattern for GO exhibits the acute peak at about 2θ=10.9°, corresponding to the graphitic oxide plane (001) with an interlayer spacing (d) of 0.81 nm. This d‐spacing is much higher than graphite (d=∼0.34 nm) due to the introduction of oxygen functional groups on the graphite sheets . After a successful hydrothermal reduction of GO to rGO, the 10.5° diffraction peak of GO is extinguished and a new broad peak appears at 2θ=24.2° with the graphitic plane (002) of the rGO sheets.…”

Section: Resultsmentioning

confidence: 99%

Reduced Graphene Oxide Supported NiCo₂O₄ Nano‐Rods: An Efficient, Stable and Cost‐Effective Electrocatalyst for Methanol Oxidation Reaction

Narayanan

Neppolian

2019

ChemCatChem

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The development of inexpensive, highly active and non-noble catalysts for the methanol oxidation reaction is extremely desirable for the practical use of direct-methanol fuel cells. Here, we have developed a template-free hydrothermal synthesis followed by calcination to produce highly active hybrid material of reduced graphene oxide (rGO) supported NiCo 2 O 4 (NiCo 2 O 4 /rGO) nano-rods as a non-expensive electro-catalyst for methanol oxidation. The electrochemical performance of the prepared NiCo 2 O 4 /rGO spinel catalyst was investigated by cyclic voltammetry (CV), chronoamperometry (CA) and electrochemical impedance spectroscopy (EIS) techniques. Impressively, the NiCo 2 O 4 /rGO showed greater electrocatalytic activity (78 mA/ cm 2 ) and stability during methanol oxidation in comparison to that of the commercial Pt/C catalyst, which was 3.11 folds higher than the commercial Pt/C (25.08 mA/cm 2 ). The NiCo 2 O 4 / rGO electrode also maintained its remarkable catalytic stability even after consecutive 500 cycles, which was~50 times higher than that of the commercial Pt/C. The overall electroactivity of NiCo 2 O 4 /rGO was remarkably enhanced by the synergistic effect between NiCo 2 O 4 and rGO. This may be due to the formation of mixed-valence cations of Ni 2 + and Co 3 + from the octahedral sites and high electron-transfer conductivity of rGO as well.[a] N.

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“…The cytotoxicity of graphene-based materials mainly depends on the physicochemical features such as the conductivity, size and density of the functional groups, the degree of functionalization, and the used cell type. [11] The toxicity of carbon nanomaterials is influenced by their functionalization degree. GO contains many carboxyl, epoxy and hydroxyl groups in comparison with GTE-rGO.…”

Section: In Vitro Cytotoxicity Evaluationmentioning

confidence: 99%

“…Most commonly used reducing agent is hydrazine. For large scale production, toxicity of hydrazine is a major concern [7] and synthesized rGO tends to agglomerate strongly due to interlayer attractive Vander Waals forces, [8] to overcome this, numerous other reducing agents have been used in literature, [9][10][11] one amongst them is reducing plant extracts, which is environmental friendly.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Antibacterial and Anticancer Performance of Reduced Graphene Oxide Prepared via Green Tea Extract Assisted Biosynthesis

et al. 2020

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Green tea extract (GTE) contains polyphenols and can play as a bioreducing and stabilizing agent. This paper describes environmentally friendly approach for synthesis of reduced graphene oxide using GTE (GTE‐rGO). The results have confirmed that biomolecules present in green tea extract not only act as bioreductant but also functionalize the surface of rGO due to hydrogen binding and π‐π stacking interactions. The 100 ppm of rGTE‐rGO showed 0.68 ppm phenols and 0.24 ppm flavones. The rGTE‐rGO was found to have highest % of 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH, 73.83 %) scavenging activity. Antibacterial activity of GTE‐rGO exhibited strong activity against Escherichia coli and Staphylococus. A cytotoxicity evaluation of GO and GTE‐rGO was carried out on fibroblast, MCF7 breast cancer and PC3 prostat cancer cells. The 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) results showed high viability loss and toxicity of GTE‐rGO against cells especially for PC3 cells. Thus, GTE‐rGO because of biomolecules present could potentially act as antioxidant, anticancer and antibacterial agent.

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Anticancer activity of graphene oxide-reduced graphene oxide-silver nanoparticle composites

Cited by 87 publications

References 26 publications

Graphene Oxide–Silver Nanoparticle Nanohybrids: Synthesis, Characterization, and Antimicrobial Properties

Graphene Oxide–Silver Nanoparticle Nanohybrids: Synthesis, Characterization, and Antimicrobial Properties

Reduced Graphene Oxide Supported NiCo₂O₄ Nano‐Rods: An Efficient, Stable and Cost‐Effective Electrocatalyst for Methanol Oxidation Reaction

Antioxidant, Antibacterial and Anticancer Performance of Reduced Graphene Oxide Prepared via Green Tea Extract Assisted Biosynthesis

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Anticancer activity of graphene oxide-reduced graphene oxide-silver nanoparticle composites

Cited by 87 publications

References 26 publications

Graphene Oxide–Silver Nanoparticle Nanohybrids: Synthesis, Characterization, and Antimicrobial Properties

Graphene Oxide–Silver Nanoparticle Nanohybrids: Synthesis, Characterization, and Antimicrobial Properties

Reduced Graphene Oxide Supported NiCo2O4 Nano‐Rods: An Efficient, Stable and Cost‐Effective Electrocatalyst for Methanol Oxidation Reaction

Antioxidant, Antibacterial and Anticancer Performance of Reduced Graphene Oxide Prepared via Green Tea Extract Assisted Biosynthesis

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Reduced Graphene Oxide Supported NiCo₂O₄ Nano‐Rods: An Efficient, Stable and Cost‐Effective Electrocatalyst for Methanol Oxidation Reaction