Anticancer Activity of Ipomoea purpurea Leaves Extracts in Monolayer and Three-Dimensional Cell Culture

Beheshti, Fatemeh; Shabani, Ali Akbar; Eidgahi, M. R. Akbari; Kookhaei, P.; Vazirian, Mahdi; Safavi, Maliheh

doi:10.1155/2021/6666567

Cited by 9 publications

(4 citation statements)

References 28 publications

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“…In this model, tumor ECM is completely controlled by CSF, which facilitates the study of the interaction between tumor cells and TME. Beheshti ( 77 ) et al. used a combination of the hanging drop method and the liquid covering method to form 3D multicellular spheres to test the anticancer effect of Ipomoea purpurea.…”

Section: D Model Construction Methods For Cancer Research and Its Rec...mentioning

confidence: 99%

Towards a New 3Rs Era in the construction of 3D cell culture models simulating tumor microenvironment

et al. 2023

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Three-dimensional cell culture technology (3DCC) sits between two-dimensional cell culture (2DCC) and animal models and is widely used in oncology research. Compared to 2DCC, 3DCC allows cells to grow in a three-dimensional space, better simulating the in vivo growth environment of tumors, including hypoxia, nutrient concentration gradients, micro angiogenesis mimicism, and the interaction between tumor cells and the tumor microenvironment matrix. 3DCC has unparalleled advantages when compared to animal models, being more controllable, operable, and convenient. This review summarizes the comparison between 2DCC and 3DCC, as well as recent advances in different methods to obtain 3D models and their respective advantages and disadvantages.

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Section: D Model Construction Methods For Cancer Research and Its Rec...mentioning

confidence: 99%

Towards a New 3Rs Era in the construction of 3D cell culture models simulating tumor microenvironment

et al. 2023

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“… Medicinal Plants Phytochemicals Application Ref. Dicoma anomala Sesquiterpenes Breast, lung, prostate cancers [ 70 ] Aloe vera Aloe emodin, Emodin Head and neck cancer, glioblastoma, colon, breast cancer, and gastric carcinoma [ 63 , 71 ] Curcuma longa Curcumin Prostate, colorectal, breast, pancreatic, and head and neck cancers [ 72 , 73 ] Ipomoea mauritiana Scopoletin Lung, liver, skin and breast cancer [ 74 , 75 , 76 ] Berberis aristate Berberine Breast and colorectal cancer [ 77 , 78 ] Ficus religiosa Furanocoumarin Breast and ovarian cancer [ 79 , 80 ] Rubia cordifolia Rubiadin Human cervical, and larynx cancer [ 69 , …”

Section: Photodynamic Therapymentioning

confidence: 99%

Efficacy of Green Synthesized Nanoparticles in Photodynamic Therapy: A Therapeutic Approach

Zahra

Chota

Abrahamse

et al. 2023

IJMS

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Cancer is a complex and diverse disease characterized by the uncontrolled growth of abnormal cells in the body. It poses a significant global public health challenge and remains a leading cause of death. The rise in cancer cases and deaths is a significant worry, emphasizing the immediate need for increased awareness, prevention, and treatment measures. Photodynamic therapy (PDT) has emerged as a potential treatment for various types of cancer, including skin, lung, bladder, and oesophageal cancer. A key advantage of PDT is its ability to selectively target cancer cells while sparing normal cells. This is achieved by preferentially accumulating photosensitizing agents (PS) in cancer cells and precisely directing light activation to the tumour site. Consequently, PDT reduces the risk of harming surrounding healthy cells, which is a common drawback of conventional therapies such as chemotherapy and radiation therapy. The use of medicinal plants for therapeutic purposes has a long history dating back thousands of years and continues to be an integral part of healthcare in many cultures worldwide. Plant extracts and phytochemicals have demonstrated the ability to enhance the effectiveness of PDT by increasing the production of reactive oxygen species (ROS) and promoting apoptosis (cell death) in cancer cells. This natural approach capitalizes on the eco-friendly nature of plant-based photoactive compounds, offering valuable insights for future research. Nanotechnology has also played a pivotal role in medical advancements, particularly in the development of targeted drug delivery systems. Therefore, this review explores the potential of utilizing photosensitizing phytochemicals derived from medicinal plants as a viable source for PDT in the treatment of cancer. The integration of green photodynamic therapy with plant-based compounds holds promise for novel treatment alternatives for various chronic illnesses. By harnessing the scientific potential of plant-based compounds for PDT, we can pave the way for innovative and sustainable treatment strategies.

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“…The flowers of I. purpurea contain antioxidant molecules such as cyanidin and pelargonidin. Also, this species along with species tricolor and violacea are enriched with ergoline derivatives such as lysergol and isoergine, so these plants are known for entheogen activities (Meira et al, 2012;Beheshti et al, 2021). This study's objectives were to assess I. purpurea leaves extracts' antioxidant activity and to characterize the possible chemical components using GC-MS.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and In Vitro Antioxidant Activity of Extracts of Ipomoea purpurea Leaves from Iran

Beheshti,

Safavi,

Eidgahi

et al. 2023

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Nowadays, the use of medicinal herbs and derivatives to improve the development of multifunctional therapeutic agents is growing. The purpose of this study is to determine the antioxidant capacity of Ipomoea purpurea leaves that grows in Iran as well as the chemical composition of the leaves. Thus, using in vitro established procedures, the antioxidant capacity of organic and aqueous extracts of I. purpurea leaves was assessed. Further, the ethanol and chloroform extracts of I. purpurea leaves were analyzed using gas chromatography-mass spectrometry (GC-MS). Concentration-dependent scavenging of 2, 2-diphenyl-2-picryl hydrazil (DPPH) was seen across all three extract types (ethanol, water, and chloroform) with the IC 50 values of 42.30 ± 2.35, 54.11 ± 3.62, and 85.71 ± 4.83 μg/mL, respectively which were higher compared to the positive control (ascorbic acid = 8.07 ± 0.30 μg/mL) and (butylated hydroxyanisole or BHA = 13.9 ± 0.54 μg/mL). The ferrous reducing antioxidant power (FRAP) of the extracts was in the following order: ethanol > aqueous > chloroform. As the ethanol extract exhibited higher levels of total phenols, (29.78 ± 0.11 mg gallic acid equivalent /100 g dry leaves weight), flavonoid (19.9 ± 3.98 mg catechin equivalent /100 g dry leaves weight), and steroids content (6.85 ± 0.07 mg steroids equivalent /100 g dry leaves weight) compared to chloroform extract. In addition, GC-MS research showed that the extracts of I. purpurea leaves contain a wide diversity of chemicals. Findings from this research revealed that I. purpurea leaves contain chemicals with excellent antioxidant and biological capabilities, which might be attributed to the existence of bioactive molecules and provide additional data for future research.

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Anticancer Activity of Ipomoea purpurea Leaves Extracts in Monolayer and Three-Dimensional Cell Culture

Cited by 9 publications

References 28 publications

Towards a New 3Rs Era in the construction of 3D cell culture models simulating tumor microenvironment

Towards a New 3Rs Era in the construction of 3D cell culture models simulating tumor microenvironment

Efficacy of Green Synthesized Nanoparticles in Photodynamic Therapy: A Therapeutic Approach

Phytochemical Screening and In Vitro Antioxidant Activity of Extracts of Ipomoea purpurea Leaves from Iran

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