Anticancer Activity of Mannich Bases: A Review of Recent Literature

Roman, Gheorghe

doi:10.1002/cmdc.202200258

Cited by 19 publications

(8 citation statements)

References 176 publications

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“…The structural imidazo (1,2-a) pyridine is present in many physiologically and pharmaceutically active molecules [2]. The other uses for them include anti-cancer [3], antibacterial [4], anti-fungal [5], and antiproliferative [6]. Imidazo [1,2-a] pyrimidines have been also found in a number of investigational drugs, such as zolpidem Hypnotic, Miroprofen (NSAID), DS-I GABAA PAM, Zolimidine Antiulcer, Olprinone cardio stimulant, and Mindronic acid osteoporotic [1].…”

Section: Introductionmentioning

confidence: 99%

“…Studies in the literature showed that Mannich bases are highly reactive and easily transform into other compounds [4], according to the published studies in the literature reduced to produce amino alcohols having physiological action, for instance. It is well-known that Mannich bases have potent effects, such as antiinflammatory, anticancer properties [5], antimicrobial, anti-filarial [6], and anticonvulsant [7].…”

Section: Introductionmentioning

confidence: 99%

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2023

J. Med. Chem. Sci.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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“…Additionally, by selecting the appropriate amine reagent, the Mannich reaction can also contribute to enhancing the lipophilic properties of a drug. [48] Extensive literature reports have highlighted the potency of Mannich base-linked 1,2,4-triazole derivatives as antibacterial, [49][50][51] antifungal, [52,53] antitubercular, [54] anti-cancer agents. [55,56] As existing drugs on the market often face challenges such as drug resistance, undesirable toxic side effects, and incompatibility with other drugs, there is an urgent need for the synthesis of novel biologically active compounds.…”

Section: Introductionmentioning

confidence: 99%

A Review of the Synthesis and Biological Activity of Flavonoid Mannich Base Derivatives

Nguyen,

Cong,

Minh An

2023

ChemistrySelect

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Over the past twenty years (1998–2023), extensive research has focused on the synthesis and biological activity of Mannich base derivatives of flavonoids (FMBD), which have demonstrated exceptional properties towards organic and bioorganic molecules. Several research groups have reported the pharmacological potential of these flavonoid derivatives, including antioxidant and antiviral activities, as well as their ability to inhibit AChE and exhibit anticancer properties. Moreover, the unique characteristic of forming stable complexes with biomolecules positions flavonoid derivatives as valuable assets in the realm of biology and drug discovery. In this extensive review, we′ve meticulously analyzed over seventy six distinct research studies on this subject. Our aim is to provide a succinct overview of the wide‐ranging applications of flavonoid derivatives coupled with amines. Furthermore, we explore the promising horizons and potential innovations in this field. It's essential to highlight that these derivatives display no discernible signs of toxicity or eliciting immune responses, making them even more attractive for biopharmaceutical applications. Undoubtedly, the utilization of flavonoid derivatives combined with amines as crucial biopharmaceutical agents is poised for significant expansion in the forthcoming years.

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“…Further researchers who also studied this type of condensation before Mannich, are van Marle and Tollens [11], Schäfer and Tollens [12], Auwers and Dombrowski [13], and Petrenko-Kritschenko and 2 of 35 his co-workers [14][15][16][17]. In recent times, the procedure has garnered notable consideration due to the versatile nature of its constituents, the use of gentle reaction conditions, and the potential pharmacological activity of the final products [18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Bioactive Aminomethylated 8-Hydroxyquinolines via the Modified Mannich Reaction

Csuvik

Szatmári

2023

IJMS

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8-hydroxyquinoline (oxine) is a widely known and frequently used chelating agent, and the pharmacological effects of the core molecule and its derivatives have been studied since the 19th century. There are several synthetic methods to modify this core. The Mannich reaction is one of the most easily implementable examples, which requires mild reaction conditions and simple chemical reagents. The three components of the Mannich reaction are a primary or secondary amine, an aldehyde and a compound having a hydrogen with pronounced activity. In the modified Mannich reaction, naphthol or a nitrogen-containing naphthol analogue (e.g., 8-hydroxyquinoline) is utilised as the active hydrogen provider compound, thus affording the formation of aminoalkylated products. The amine component can be ammonia and primary or secondary amines. The aldehyde component is highly variable, including aliphatic and aromatic aldehydes. Based on the pharmacological relevance of aminomethylated 8-hydroxyquinolines, this review summarises their syntheses via the modified Mannich reaction starting from 8-hydroxyquinoline, formaldehyde and various amines.

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Anticancer Activity of Mannich Bases: A Review of Recent Literature

Cited by 19 publications

References 176 publications

Untitled

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A Review of the Synthesis and Biological Activity of Flavonoid Mannich Base Derivatives

Synthesis of Bioactive Aminomethylated 8-Hydroxyquinolines via the Modified Mannich Reaction

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