2013
DOI: 10.1016/j.jopr.2013.04.027
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Anticancer activity of methanol extract of the seeds of Borreria hispida and Momordica dioica

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Cited by 13 publications
(13 citation statements)
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“…3.4.1 Cell viability assay: NPs are recognised as promising candidates in nano therapeutics, as they acquire low inherent toxicity, more surface area, stability, and non-immunogenicity, which provide them with unique application in therapeutic strategies. In order to test the effectiveness of the AuNPs, the cell viability was determined using MTT assay in different cancer and normal cells [27]. The cell viability results indicated that the activity of the AuNPs was concentration-dependent.…”
Section: Anticancer Studiesmentioning
confidence: 99%
See 1 more Smart Citation
“…3.4.1 Cell viability assay: NPs are recognised as promising candidates in nano therapeutics, as they acquire low inherent toxicity, more surface area, stability, and non-immunogenicity, which provide them with unique application in therapeutic strategies. In order to test the effectiveness of the AuNPs, the cell viability was determined using MTT assay in different cancer and normal cells [27]. The cell viability results indicated that the activity of the AuNPs was concentration-dependent.…”
Section: Anticancer Studiesmentioning
confidence: 99%
“…3). The AuNPs showed significant activity against HeLa, MCF-7, and A549 cell lines with IC 50 values of 87.2, 94.5, and 90.0 μg/ml, respectively [27,28] (Table 2). Among all the tested, AuNPs showed good activity in HeLa cells as compared to other cells.…”
Section: Anticancer Studiesmentioning
confidence: 99%
“…40,41 Consistent with them containing cyclotides, whole plant methanol extracts from M. cochinchinensis and M. dioica are cytotoxic to some cancer cell lines. 27,42 Furthermore, a recent study showed a novel peptide isolated from M. charantia possessed high trypsin inhibitory activity and was cytotoxic against a colon cancer cell line. 43 In addition to their cytotoxic effects on mammalian cells, squash inhibitors are presumed to have a role in plant defense mechanisms, 44 and inhibit several serine proteinases including trypsin, plasmin, and cathepsin G. 45 Based on the abovementioned studies, we investigated whether the Modi peptides were cytotoxic against either an insect cell line (Spodoptera frugiperda) or against human colon, breast, or prostate cancer cells.…”
Section: Modi 2 and Modi 4 Share Sequences With Two Reported Peptidesmentioning
confidence: 99%
“…26 However, to expand our knowledge on TIs and provide more drug scaffold options, it is important to screen other species from Cucurbitaceae, including those of the Momordica genus. As extracts from Momordica dioica (a climbing plant with the same origin as M. cochinchinensis 20 ) have been found to possess anticancer and antidiabetic activity, 27,28 this species is the focus of the current study.…”
mentioning
confidence: 99%
“…It has been observed that the combination of cucurbitacin E with other synthetic anti-cancer drugs results in synergistic action in terms of cytotoxicity with greater efficacy in tumor growth inhibition [7] . Despite the potential therapeutic activity of Cucurbitacin E and cucurbitacin E glycoside, their chronic exposure is undesirable due to their extremely bitter and disagreeable taste as well as their toxicological effects found in experimental animals [8] . It has been presumed that back mutated fruits produce more toxicity and bitterness whereas the suppressor gene is responsible for the absence of cucurbitacins [9] .…”
Section: Introductionmentioning
confidence: 99%