Anticancer Activity of Micromeria fruticosa and Teucrium polium Growing in Lebanon

Abstract

The air-dried and ground aerial parts of M. fruticosa and T. polium were subjected to excessive alcoholic extraction at room temperature until exhaustion.

FTICR/MS Analysis of Micromeria Fruticosa and Teucrium Polium Growing in Lebanon

“…Dr. Ali Chakas a botanist from the Lebanese University, Faculty of Science) authenticated the plants. Both plant samples processed as described before 6 Chromatographic separation.…”

“…As fully described in our previous study, crude extracts of Micromeria fruticosa (extract A) and Toucrium polium (extract B) were separated using column chromatography, followed by chromatographic isolation of their fractions via elution using mixtures of different organic solvents, yielding 22 fractions for A and 43 fractions for B. 6…”

“…13 In conclusion, ultrahigh-resolution MS technologies offer accurate molecular weight information, which in turn can be used to predict the elemental compositions (molecular formulas) of metabolites as clues for their structural elucidation. 7 Previously, 6 we found that the crude extracts of Micromeria fruticosa and Teucrium polium, as well as some of their fractions, exhibit significant anticancer activity. This activity motivated us to use this advanced technique to investigate the chemical classes and active ingredients in crude extracts of both plants and their fractions that are responsible for these findings.…”

“…4,5 They have long been used to treat a variety of maladies, including migraines, gastrointestinal disorders, upper respiratory tract infections, and several cardiovascular diseases. 6 Both Micromeria and Teucrium are reported as an important source of flavonoid, terpenoid, and phenolic substances responsible for the extensive range of medicinal applications for their antioxidant and anticancer effects. 6 As an essential aspect of genomics research, Metabolomics aims to gain a comprehensive understanding of metabolic networks by analyzing a wide range of known and novel metabolites found in living organisms simultaneously.…”

“…6 Both Micromeria and Teucrium are reported as an important source of flavonoid, terpenoid, and phenolic substances responsible for the extensive range of medicinal applications for their antioxidant and anticancer effects. 6 As an essential aspect of genomics research, Metabolomics aims to gain a comprehensive understanding of metabolic networks by analyzing a wide range of known and novel metabolites found in living organisms simultaneously. The first stage of metabolomics was built up to allow for reliable analyses of known metabolites by comparing them to previously identified compounds.…”