Anticancer activity of novel silicon phthalocyanines against the colorectal adenocarcinoma cell line (DLD-1)

Abstract

In this study, the DNA cleavage activities of a series of new silicon phthalocyanines were studied to measure their potential for cancer treatment. For this purpose, 2-(2,4,6-tris((dimethylamino)methyl)phenoxy)ethan-1-ol (2) and 2-(2-(2,4,6-tris((dimethylamino)methyl)phenoxy)ethoxy)ethan-1-ol...

Effect of Axial Ligand Length on Biological and Anticancer Properties of Axially Disubstituted Silicon Phthalocyanines

“…The pathways for the synthesis of compounds 2 and 3 are depicted in Scheme 1. Compounds 2 and 3 were prepared through the reaction of N,N‐diethylaminoetantiol and 2‐chloroethanol or 2‐(2‐chloroethoxy)ethanol [19] . The products were purified using column chromatography on silica gel as the stationary phase and methanol as the mobile phase.…”

“…Compounds 2 and 3 were prepared through the reaction of N,N-diethylaminoetantiol and 2-chloroethanol or 2-(2-chloroethoxy)ethanol. [19] The products were purified using column chromatography on silica gel as the stationary phase and methanol as the mobile phase. The characterization of the newly synthesized compounds was carried out by performing FT-IR and 1 H-NMR spectroscopic techniques.…”

“…Additionally, their chemically and thermally stable structure and the ease of their coordination with most elements make them suitable materials for different applications such as photodynamic therapy (PDT), antimicrobial, antibiofilm, and pathological bacteria/fungi photoinactivation. Due to the flexibility of the phthalocyanine ring leading to the possibility of its periphery/core alteration, the potent utility of phthalocyanines for biological and medical studies has been interesting by researchers in recent years [18–20] . Also, the substituted phthalocyanines exhibit better solubility than unsubstituted ones tending to accumulation and aggregation.…”

“…Due to the flexibility of the phthalocyanine ring leading to the possibility of its periphery/core alteration, the potent utility of phthalocyanines for biological and medical studies has been interesting by researchers in recent years. [18][19][20] Also, the substituted phthalocyanines exhibit better solubility than unsubstituted ones tending to accumulation and aggregation. The presence of axial ligand(s) on the metal center decreases π-π stacking that in turn diminishes aggregation.…”