Anticancer activity of polyoxomolybdate

Yanagië, Hironobu; Ogata, Aya; Mitsui, Shun; Hisa, Tomoyuki; Yamase, Toshihiro; Eriguchi, Masazumi

doi:10.1016/j.biopha.2006.06.018

Cited by 119 publications

(76 citation statements)

References 28 publications

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“…Since the discovery of the antitumor activity of cisplatin, a number of inorganic metal compounds have been used as important therapeutic agents and diagnostic imaging probes [4][5][6][7][8][9][10][11][12][13][14][15] . Worldwide sales of inorganic drugs are rapidly increasing.…”

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confidence: 99%

“…Worldwide sales of inorganic drugs are rapidly increasing. However, few inorganic agents have been reported that can inhibit Ab amyloid formation [6][7][8][9][10][11] . Polyoxometalates (POMs) are early transition metal oxide clusters (especially Mo, W and V) with high oxidation states, and they are used for constructing molecular architectures with potential applications 16 , for example, in catalysis 17 , magnetic materials 18 , chiral recognition 19 or nanocomposites 20 .…”

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confidence: 99%

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Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer’s disease

et al. 2014

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Inhibitions of amyloid b (Ab) aggregation and Ab-haem peroxidase-like activity have received much attention because these two symptoms can be the primary targets of therapeutic strategies for Alzheimer's disease (AD). Recently, our group found that polyoxometalate (POM) with a Wells-Dawson structure can efficiently inhibit Ab aggregation. However, the interaction between POMs and Ab is robust, but still needs to improve Ab binding affinity. More importantly, it is unclear whether POMs can cross the blood-brain barrier and decrease Ab-haem peroxidase-like activity. Here we show that our designed series of transition metal-functionalized POM derivatives with a defined histidine-chelated binding site have much better Ab inhibition and peroxidase-like activity inhibition effects than the parent POM. More intriguingly, we show that these compounds can cross the blood-brain barrier and are metabolized after 48 h. Our work provides insights into the design, synthesis and screening of inorganic metal compounds as multifunctional therapeutic agents against AD.

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Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer’s disease

et al. 2014

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“…[NH 3 Pr i ] 6 [Mo 7 O 24 ] Á 3H 2 O (PM-8) was found to exhibit potent antitumour activity against MX-1 human breast cancer, Meth-A sarcoma, and MM46 adenocarcinoma in vivo (Yamase et al, 1988). Recent work from our laboratory showed that the efficacy of PM-8 has been recognised also for both AsPC-1 human pancreatic cancer and MKN45 human gastric cancer, which results from activation of the apoptotic pathway (Ogata et al, 2005;Mitsui et al, 2006;Yanagie et al, 2006). It has been proposed that PM-8 could be preferentially taken into tumour cells and converted into an approximately 10-fold more toxic species, produced through biological reduction probably in the mitochondrial system.…”

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Antitumour effect of polyoxomolybdates: induction of apoptotic cell death and autophagy in in vitro and in vivo models

et al. 2007

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O. The effect of PM-17 on the growth of cancer cell lines and xenografts was assessed by a cell viability test and analysis of tumour expansion rate. Morphological analysis was carried out by Hoechst staining, flow-cytometric analysis of Annexin V staining, terminal deoxynucleotidyl transferase-mediated 'nick-end' labelling staining, and electron-microscopic analysis. Activation of autophagy was detected by western blotting and fluorescence-microscopic analysis of the localisation of GFP-LC3 in transfected tumour cells. PM-17 inhibited the growth of human pancreatic cancer (AsPC-1) xenografts in a nude mice model, and induced morphological alterations in tumour cells. Correspondingly, PM-17 repressed the proliferation of AsPC-1 cells and human gastric cancer cells (MKN45) depending on the dose in vitro. We observed apoptotic patterns as the formation of apoptotic small bodies and translocation of phosphatidylserine by Hoechst staining and flow-cytometric analysis following Annexin V staining, and in parallel, autophagic conformation by the formulation of autophagosomes and localisation of GFP-LC3 by electron-and fluorescence-microscopic analysis.

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“…Polyoxometalates (POMs) are a unique class of metal oxide anions exhibiting a large variety of structural versatility and interesting physical properties, [1][2][3] as well as the ability to show variable redox potentials. [4] Wells-Dawson-type (WD) clusters with a general formula of [W 18 O 54 (XO 4 …”

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confidence: 99%

“…These techniques show that the cluster undergoes a structural rearrangement in solution whereby the {HPO 3 } moieties dimerize to form a weakly interacting (O 3 PH···HPO 3 ) moiety. In the crystalline state the cluster exhibits a thermally triggered oxidation of the two P III template moieties to form P V centers (phosphite to phosphate), commensurate with the transformation of the cage into a Wells-Dawson {W 18 O 54 } cluster.Polyoxometalates (POMs) are a unique class of metal oxide anions exhibiting a large variety of structural versatility and interesting physical properties, [1][2][3] as well as the ability to show variable redox potentials.[4] Wells-Dawson-type (WD) clusters with a general formula of [W 18 O 54 , etc.) are one of the most widely investigated families of molecules in the POM family.…”

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Following the Reaction of Heteroanions inside a {W₁₈O₅₆} Polyoxometalate Nanocage by NMR Spectroscopy and Mass Spectrometry

et al. 2015

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, was isolated, in which the reaction of the two phosphite anions [HPO 3 ] 2À within the {W 18 O 56 } cage could be followed spectroscopically. As well as full X-ray crystallographic analysis, we studied the reactivity of the cluster using both solution-state NMR spectroscopy and mass spectrometry. These techniques show that the cluster undergoes a structural rearrangement in solution whereby the {HPO 3 } moieties dimerize to form a weakly interacting (O 3 PH···HPO 3 ) moiety. In the crystalline state the cluster exhibits a thermally triggered oxidation of the two P III template moieties to form P V centers (phosphite to phosphate), commensurate with the transformation of the cage into a Wells-Dawson {W 18 O 54 } cluster.Polyoxometalates (POMs) are a unique class of metal oxide anions exhibiting a large variety of structural versatility and interesting physical properties, [1][2][3] as well as the ability to show variable redox potentials.[4] Wells-Dawson-type (WD) clusters with a general formula of [W 18 O 54 , etc.) are one of the most widely investigated families of molecules in the POM family.[5] WD clusters are described as rigid nanocages {W 18 O 54 } in which two tetrahedral heteroanions {XO 4 } are embedded and their electrochemistry has been extensively examined.[6] However, the properties of WD clusters are mainly attributed to the multiple redox states of the rigid metal oxide framework. We have successfully manipulated the redox behavior of WD clusters by introducing electronically active heteroatoms into the metal oxide shell. In this respect, a series of novel 4À into a flash memory architecture. [8] This result drove us to the development of a new heteroatom-templated functional system. However, despite this work [7,8] we are yet to obtain direct spectroscopic evidence demonstrating the reactivity of heteroanions "trapped" within a molecular metal oxide polyoxometalate nanocage.Herein, we report a system that allows us to directly probe the transformation of reactive templates within a polyoxometalate nanocage using NMR spectroscopy and mass spectrometry. To do this we designed and synthesized a P . Energy values for the HOMO-LUMO gap (HLG) for compounds 1 a, 2 a, and 3 a are given in eV, and their frontier orbitals are shown in Figure S13. Atom colors: O = red; P = orange; W = dark gray; H = light gray.

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Anticancer activity of polyoxomolybdate

Cited by 119 publications

References 28 publications

Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer’s disease

Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer’s disease

Antitumour effect of polyoxomolybdates: induction of apoptotic cell death and autophagy in in vitro and in vivo models

Following the Reaction of Heteroanions inside a {W₁₈O₅₆} Polyoxometalate Nanocage by NMR Spectroscopy and Mass Spectrometry

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Anticancer activity of polyoxomolybdate

Cited by 119 publications

References 28 publications

Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer’s disease

Transition-metal-substituted polyoxometalate derivatives as functional anti-amyloid agents for Alzheimer’s disease

Antitumour effect of polyoxomolybdates: induction of apoptotic cell death and autophagy in in vitro and in vivo models

Following the Reaction of Heteroanions inside a {W18O56} Polyoxometalate Nanocage by NMR Spectroscopy and Mass Spectrometry

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Following the Reaction of Heteroanions inside a {W₁₈O₅₆} Polyoxometalate Nanocage by NMR Spectroscopy and Mass Spectrometry