Anticancer activity of Salvia officinalis essential oil and its principal constituents against hormone-dependent tumour cells

Privitera, Giovanna; Luca, Tonia; Castorina, Sergio; Passanisi, Roberta; Ruberto, Giuseppe; Napoli, Edoardo

doi:10.4103/2221-1691.250266

Cited by 36 publications

(26 citation statements)

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“…Similarly, Zolotovich et al [44] reported that thujone exhibits no cytotoxic effect on HeLa cells at high concentrations (100 µg/mL), which supports the outcome of present study. Likewise, Privitera et al [5] documented that thujone-rich essential oil from Salvia officinalis has no cytotoxic effect on the LNCaP cells in all tested concentrations that strengthen the present findings.…”

Section: Antiproliferative Activitysupporting

confidence: 89%

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Antioxidant and Antiproliferative Potential of Bioactive Molecules Ursolic Acid and Thujone Isolated from Memecylon edule and Elaeagnus indica and Their Inhibitory Effect on Topoisomerase II by Molecular Docking Approach

Ramalingam

Arumugam²,

Lee

et al. 2020

BioMed Research International

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The present study aimed to evaluate the antioxidant and antiproliferative potential of ursolic acid and thujone isolated from leaves of Elaeagnus indica and Memecylon edule and their inhibitory effect on topoisomerase II using molecular docking study. The isolated ursolic acid and thujone were examined for different types of free radicals scavenging activity, the antiproliferative potential on U-937 and HT-60 cell lines by adopting standard methods. Further, these compounds were docked with the active site of the ATPase region of topoisomerase II. The findings of the research revealed that ursolic acid harbor strong antioxidant and antiproliferative capacity with low IC50 values than the thujone in all tested methods. Moreover, ursolic acid shows significant inhibition effect on topoisomerase II with a considerable docking score (−8.0312) and GLIDE energy (−51.86 kca/mol). The present outcome concludes that ursolic acid possesses significant antioxidant and antiproliferative potential, which can be used in the development of novel antioxidant and antiproliferative agents in the future.

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Section: Antiproliferative Activitysupporting

confidence: 89%

“…However, these therapies are expensive and cause an adverse effect on host health. Several plant-derived compounds like vinblastine, vincristine, taxol, and camptothecin were used in the treatment of cancer [5].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant and Antiproliferative Potential of Bioactive Molecules Ursolic Acid and Thujone Isolated from Memecylon edule and Elaeagnus indica and Their Inhibitory Effect on Topoisomerase II by Molecular Docking Approach

Ramalingam

Arumugam²,

Lee

et al. 2020

BioMed Research International

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show abstract

“…Similarly different doses of essential oil (EO) containing α-thujone, 1,8-cineole, and camphor from aromatic plant Salvia officinalis were studied for antitumor activity against human hormone-dependent tumor cell lines, viz., LNCaP (prostate cancer), MCF 7 (breast cancer), and HeLa (cervical cancer), and it was identified that both oil and its components significantly reduced the viability of cancer cells after 2 days incubation. The authors suggested that the EO and its fractions induced apoptosis via P13K/AKT and MAPK/ERK pathways along with cell cycle arrest and by alleviating the levels of reactive oxygen and nitrogen species (Privitera et al 2020).…”

Section: Anti-carcinogenic Activitymentioning

confidence: 99%

Bioactive Secondary Metabolites of Medicinal and Aromatic Plants and Their Disease-Fighting Properties

Kaur

Ahmed

2021

Medicinal and Aromatic Plants

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“…Essential oils (EOs) are complex mixtures formed constituted of compounds with varying functional groups. Several therapeutic activities linked to EOs include anti-inflammatory, antimicrobial, analgesic, antimycotic, antidiabetic, antioxidant, anti-cancer [9,10,32]. The GC-MS fatty acid analysis revealed eight fatty acids of which the primary constituents are n-Hexadecanoic acid, Octadecenoic acid, and Oleic acid with a percentage yield of 35.07%, 28.26%, and 17.90%, respectively.…”

Section: Biochemical Analysesmentioning

confidence: 99%

“…A myriad of biological activities has been attributed to essential oils extracted from the flowers, leaves, stems, and roots of aromatic plants. Specifically leaf-derived essential have been studied for antibacterial [4,5], antioxidant [6,7], antifungal [8], anti-diabetic [9], anti-cancer [10,11] ; anti-parasitic [12,13], anti-aging [14], anti-inflammatory [15] and hepatoprotective [16,17] effects. The components and functional groups of the essential oils contribute to their bio-activities.…”

Section: Introductionmentioning

confidence: 99%

Essential oil of Alchornea laxiflora (benth): phytochemical, antimicrobial and toxicity evaluations

2019

Lett Appl NanoBioSci

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Alchornea laxiflora belonging to the Euphorbiaceae family has ethnomedicinal applications as antimalarial, anti-inflammatory, and anti-microbial agent. This present study investigated the spectroscopic, antibacterial, and toxicity profile of essential oil of Alchornea laxiflora (ALEO). The composition of ALEO was detected using Gas Chromatography-Mass Spectrometry (GC-MS) and Fourier Transform Infrared (FTIR) Spectroscopy. Using agar disc diffusion, the antibacterial activity of ALEO against five clinical isolates: Bacillus subtilis ATCC 6633, Bacillus cereus ATCC 10872, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 9027, and Staphylococcus aureus ATCC 25923 was evaluated. The toxicity profile of ALEO was obtained in studies involving Wistar rats. GC-MS analysis identified eight bioactive compounds, mostly fatty acids and their ester derivatives. The FTIR spectrum revealed peaks at 3500-3180 cm‾¹ and 2950-2800 cm‾¹ corresponding to O-H stretch band of alcohol and the C-H stretch of aliphatic alkane, respectively. The highest zone of inhibition diameter was recorded against Bacillus cereus ATCC 10872 and Escherichia coli ATCC 25922, while the least zone of inhibition was against Pseudomonas aeruginosa ATCC 9027. Oral administration of ALEO caused an elevation in Alanine aminotransferase activity. The essential oil of Alchornea laxiflora has potential as an antibacterial. However, the doses used in this study might be slightly hepatotoxic

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Anticancer activity of Salvia officinalis essential oil and its principal constituents against hormone-dependent tumour cells

Cited by 36 publications

References 1 publication

Antioxidant and Antiproliferative Potential of Bioactive Molecules Ursolic Acid and Thujone Isolated from Memecylon edule and Elaeagnus indica and Their Inhibitory Effect on Topoisomerase II by Molecular Docking Approach

Antioxidant and Antiproliferative Potential of Bioactive Molecules Ursolic Acid and Thujone Isolated from Memecylon edule and Elaeagnus indica and Their Inhibitory Effect on Topoisomerase II by Molecular Docking Approach

Bioactive Secondary Metabolites of Medicinal and Aromatic Plants and Their Disease-Fighting Properties

Essential oil of Alchornea laxiflora (benth): phytochemical, antimicrobial and toxicity evaluations

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