Anticancer agent synthesis designed by artificial intelligence: Pd(OAc)2-catalyzed one-pot preparation of biphenyls and its application to a concise synthesis of various diazofluorenes

Sequential One‐Pot Process to Construct a Dual C−C Bond: Synthesis of Fluorenes and Total Synthesis of 4‐O‐Demethyl‐nobilone

“…The compounds dendroflorin and nobilone show potent anti-oxidant properties, [8] and 1-methoxydiazofluorene acts as an anti-cancer agent. [11] Recently, in 2021, 4-O-demethyl-nobilone was extracted from the aerial parts of Dendrobium nobile Lindl. [3] Fluorene derivatives have also been known for their significant applications in material science, particularly in organic materials, including optoelectronics, [12,13] and organic semiconductors.…”

“…In addition, dengibsin, a fluorenone‐based natural product, was isolated from Dendrobium gibsonii an Orchidaceae plant, [6] whereas nobilone was isolated from the aerial parts Dendrobium nobile , [7] and genus Dendrobium was the biological source of dendroflorin [9] (Figure 1). The compounds dendroflorin and nobilone show potent anti‐oxidant properties, [8] and 1‐methoxydiazofluorene acts as an anti‐cancer agent [11] . Recently, in 2021, 4 ‐O ‐demethyl‐nobilone was extracted from the aerial parts of Dendrobium nobile Lindl [3] .…”