Anticancer and antithrombin activity of Russian plants

Goun, Elena A.; Петриченко, В. М.; Solodnikov, S.U; Suhinina, T.V; Kline, Martin; Cunningham, Glenn N.; Nguyen, Chi L.; Miles, Howard

doi:10.1016/s0378-8741(02)00116-2

Cited by 93 publications

(51 citation statements)

References 27 publications

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“…Valuable anticancer agents in the birch tree bark are pentacyclic triterpenes, mainly betulin and betulinic acid Soica et al, 2012). Extract prepared from oak has also reported to exhibit tumoricidal activity inhibiting the growth of murine leukemia cells (Goun et al, 2002). In contrast, no data about the potential antitumor activity of Pinus sylvestris, Sorbus aucuparia, and Prunus padus can be found in the literature, although the use of all these remedies has clearly reported in the Estonian ethnomedicinal data collections.…”

Section: Treesmentioning

confidence: 99%

Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Sak¹,

Jürisoo

Raal

2014

Pharmaceutical Biology

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Context: Despite diagnostic and therapeutic advancements, the burden of cancer is still increasing worldwide. Toxicity of current chemotherapeutics to normal cells and their resistance to tumor cells highlights the urgent need for new drugs with minimal adverse side effects. The use of natural anticancer agents has entered into the area of cancer research and increased efforts are being made to isolate bioactive products from medicinal plants. Objective: To lead the search for plants with potential cytotoxic activity, ethnopharmacological knowledge can give a great contribution. Therefore, the attention of this review is devoted to the natural remedies traditionally used for the cancer treatment by Estonian people over a period of almost 150 years. Methods: Two massive databases, the first one stored in the Estonian Folklore Archives and the second one in the electronic database HERBA (http://herba.folklore.ee/), containing altogether more than 30 000 ethnomedicinal texts were systematically reviewed to compile data about the Estonian folk traditional experiences on natural anticancer remedies.

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Section: Treesmentioning

confidence: 99%

Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Sak¹,

Jürisoo

Raal

2014

Pharmaceutical Biology

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“…The nutritional composition of this species, including minerals, vitamin A, ascorbic acid, proteins, linoleic acid and ω3 polyunsaturated fatty acids, is considered to be beneficial to human health (Zennie & Ogzewalla, 1977;Guil-Guerrero et al, 1999). Besides this, C. bursa-pastoris has some medicinal properties, being indicated as anti-bleeding, anticancer, antithrombin (Bekker et al, 2002;Goun et al, 2002), wound-healing (Park et al, 2000) and antioxidant agent (Ivanova et al, 2005), as well as for diabetes and fever treatment (Kweon et al, 1996). However, an approach to the chemical composition was not provided by the authors.…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and biological screening of Capsella bursa-pastoris

Grosso¹,

Vinholes²,

Silva³

et al. 2011

Rev. bras. farmacogn.

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Capsella bursa-pastoris (L.) Medik. (Brassicaceae) is a wild herb with high nutritional value that can be eaten raw or cooked. A metabolomic study was performed with different extracts of its aerial parts that were tested concerning their antiradical, acetylcholinesterase inhibitory and antibacterial activities. Phenolic compounds were identified and quantified by HPLC-DAD, organic acids and amino acids were determined by HPLC-UV, while free fatty acids and sterols were analysed by GC-ITMS. The vegetal material was rich in kaempferol-3-O-rutinoside (mean value 2247.09 mg/kg of dry plant), quinic acid (95628.00 mg/kg of dry plant), arginine (mean value of 1.18 mg/kg of dry plant), palmitic acid (284.48 mg/kg) and β-sitosterol (28%). The extracts presented a concentration-dependent antiradical activity (against DPPH• , O 2 •-and LOO • ), being most effective against • NO (EC25 0.20 μg/mL). In addition, the extracts were also acetylcholinesterase inhibitors and antibacterial active, revealing that, besides the plant's good nutritional value, it presents important biological properties as well.

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“…It is very useful in the treatment of skin diseases, in treating fevers, gravel, stone, and bladder and kidney troubles [5,6]. The methylene chloride extract of B. tripartita has demonstrated to have high activity in the inhibition of cancer L1210 (mouse leukemia) cells and against thrombin [7]. Extensive phytochemical studies on B. tripartita have shown the presence of flavonoids [8][9][10][11], coumarins [12], essential oil [13], polysaccharides, carotenoids, -lactones, amines and mineral elements [10,14].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial and antifungal activities of the extracts and essential oils of Bidens tripartita.

Tomczykowa

Jakoniuk²,

Tryniszewska³

2008

Folia Histochem Cytobiol.

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Essential oils and plant extracts preparation. The essential oil (BTHO) was hydrodistilled (3 h) from the freshly picked flowering aerial parts of the herb (500 g) using a Deryng-type apparatus. The oil (BTFO) was obtained also from dried flower heads (210 g) using the same distillation method [13].Dried and powdered B. tripartita flowers (BF) and herb (BH) were subjected to several extraction procedures: water, FOLIA HISTOCHEMICA ET CYTOBIOLOGICA Vol. 46, No. 3, 2008 pp. 389-393 Antimicrobial and antifungal activities of the extracts and essential oils of Bidens tripartita Abstract: The aim of this study was to determine the antibacterial and antifungal properties of the extracts, subextracts and essential oils of Bidens tripartita flowers and herbs. In the study, twelve extracts and two essential oils were investigated for activity against different Gram-positive Bacillus subtilis, Micrococcus luteus, Staphylococcus aureus, Gram-negative bacteria Escherichia coli, E. coli (β-laktamase+), Klebsiella pneumoniae (ESBL+), Pseudomonas aeruginosa and some fungal organisms Candida albicans, C. parapsilosis, Aspergillus fumigatus, A. terreus using a broth microdilution and disc diffusion methods. The results obtained indicate antimicrobial activity of the tested extracts (except butanolic extracts), which however did not inhibit the growth of fungi used in this study. Bacteriostatic effect of both essential oils is insignificant, but they have strong antifungal activity. These results support the use of B. tripartita to treat a microbial infections and it is indicated as an antimicrobial and antifungal agent, which may act as pharmaceuticals and preservatives.

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Anticancer and antithrombin activity of Russian plants

Cited by 93 publications

References 27 publications

Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Estonian folk traditional experiences on natural anticancer remedies: From past to the future

Chemical composition and biological screening of Capsella bursa-pastoris

Antimicrobial and antifungal activities of the extracts and essential oils of Bidens tripartita.

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