Anticancer and Antiviral Estimation of Three Ulmus pravifolia Extracts and their Chemical Constituents

Hamed, Manal M.; El-Amin, Samir M.; Refahy, Laila A.; Soliman, E. A.; Mansour, Wafaa; Taleb, Hoda M. Abu

doi:10.13005/ojc/310341

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…Several Ulmus species reportedly possess anti-oxidative (Jung et al, 2010) and anti-platelet (Yang et al, 2013) properties. Ulmus parvifolia Jacq., commonly known as the Chinese Elm or Lacebark Elm, is native to Korea, Japan, and China, reportedly possesses anti-inflammatory (Mina et al, 2016), anti-allergic (Kim et al, 2016), anti-viral, and anticancer (Hamed et al, 2015) properties. While investigating newer and safer efficacious ethnomedicinal products, we recognized the medicinal properties of U. parvifolia bark.…”

Section: Introductionmentioning

confidence: 99%

Ulmus parvifolia Modulates Platelet Functions and Inhibits Thrombus Formation by Regulating Integrin αIIbβ3 and cAMP Signaling

et al. 2020

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Background: The prevalence of cardiovascular diseases (CVDs) is increasing at a high rate, and the available treatment options, sometimes, have complications which necessitates the need to develop safer and efficacious approaches. Ethnomedicinal applications reportedly reduce CVD risk. Ulmus parvifolia Jacq. (Ulmaceae) commonly known as Chinese Elm or Lacebark Elm, is native to China, Japan, and Korea. It exhibits anti-inflammatory, antiviral, and anticancer properties, but its anti-platelet properties have not yet been elucidated. Purpose: To investigate the pharmacological anti-platelet and anti-thrombotic effects of U. parvifolia bark extract. Study Design and Methods: Human and rat washed platelets were prepared; light transmission aggregometry and scanning electron microscopy was performed to assess platelet aggregation and the change in platelet shape, respectively. Intracellular calcium mobilization, ATP release, and thromboxane-B2 production were also measured. Integrin a IIb b 3 activation was analyzed in terms of fibrinogen binding, fibronectin adhesion, and clot retraction. The expression of MAPK, Src, and PI3K/Akt pathway proteins was examined. Cyclic nucleotide signaling pathway was evaluated via cAMP elevation and VASP phosphorylation. Anti-thrombotic activity of the extract was evaluated in vivo using an arteriovenous shunt rat model, whereas its effect on hemostasis in mice was assessed via bleeding time assay. Results: U. parvifolia extract significantly inhibited human and rat platelet aggregation in a dose-dependent manner along with inhibition of calcium mobilization, dense granule secretion, and TxB2 production. Integrin a IIb b 3 mediated inside-out and outside-in signaling events, as evidenced by the inhibition of fibrinogen binding, fibronectin adhesion, and clot retraction. The extract significantly reduced phosphorylation of Src,

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Section: Introductionmentioning

confidence: 99%

Ulmus parvifolia Modulates Platelet Functions and Inhibits Thrombus Formation by Regulating Integrin αIIbβ3 and cAMP Signaling

et al. 2020

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“…UP was also reported to inhibit nitric oxide production in lipopolysaccharide-treated RAW 264.7 murine macrophages [ 15 ], exhibit anticancer and antiviral properties [ 16 ], and accelerates skin wound healing [ 17 ]. However, there were no reports on the antiobesity effects of the bark extract of UP.…”

Section: Introductionmentioning

confidence: 99%

Ulmus parvifolia Jacq. Exhibits Antiobesity Properties and Potentially Induces Browning of White Adipose Tissue

Lee

Kim

Irfan

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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The bark of Ulmus parvifolia Jacq. (UP) was traditionally used as a diuretic and to treat intestinal inflammation. With modern evidence of the correlation of diuretics, gut inflammation, and obesity, our study has shown the antiobesity effects of the bark of UP. UP treatment reduced lipid production and adipogenic genes in vitro. In vivo studies revealed that UP 100 mg/kg and UP 300 mg/kg treatment significantly reduced mouse weight without reducing food intake, indicating increased energy expenditure. UP significantly reduced the weight of epididymal and subcutaneous adipose tissue and decreased liver weight. Histological analysis revealed improvement in the progression of nonalcoholic fatty liver disease and epididymal white adipose tissue hypertrophy induced by a HFD. Real-Time PCR of epididymal adipose tissue revealed significant increases of uncoupling protein-1 (UCP-1) and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) expression after UP 300 mg/kg treatments. Phosphorylation of AMP-activated protein α (AMPKα) was increased, while phosphorylation of Acetyl-CoA Carboxylase (ACC) was reduced. Our findings reveal the ability of UP to reduce the occurrence of obesity through increased browning of white adipose tissue via increased AMPKα, PPARγ, PGC-1α, and UCP-1 expression.

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Comparison analysis of metabolite profiling in seeds and bark ofUlmus parvifolia, a Chinese medicine species

Yin

Wang³

et al. 2022

Plant Signaling & Behavior

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Ulmus parvifolia ( U. parvifolia ) is a Chinese medicine plant whose bark and leaves are used in the treatment of some diseases such as inflammation, diarrhea and fever. However, metabolic signatures of seeds have not been studied. The seeds and bark of U. parvifolia collected at the seed ripening stage were used for metabolite profiling analysis through the untargeted metabolomics approach. A total of 2,578 and 2,207 metabolites, while 503 and 132 unique metabolites were identified in seeds and bark, respectively. Additionally, 574 differential metabolites (DEMs) were detected in the two different organs of U. parvifolia , which were grouped into 52 classes. Most kinds of metabolites classed into prenol lipids class. The relative content of flavonoids class was the highest. DEMs contained some bioactive compounds (e.g., flavonoids, terpene glycosides, triterpenoids, sesquiterpenoids) with antioxidant, anti-inflammatory, and anti-cancer activities. Most kinds of flavonoids and sesquiterpenes were up-regulated in seeds. There were more varieties of terpene glycosides and triterpenoids showing up-regulated in bark. The pathway enrichment was performed, while flavonoid biosynthesis, flavone and flavonol biosynthesis were worthy of attention. This study identified DEMs with pharmaceutical value between seeds and bark during seed maturation and offered a molecular basis for alternative or complementary use of seeds and bark of U. parvifolia as a Chinese medicinal material.

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Anticancer and Antiviral Estimation of Three Ulmus pravifolia Extracts and their Chemical Constituents

Cited by 5 publications

References 18 publications

Ulmus parvifolia Modulates Platelet Functions and Inhibits Thrombus Formation by Regulating Integrin αIIbβ3 and cAMP Signaling

Ulmus parvifolia Modulates Platelet Functions and Inhibits Thrombus Formation by Regulating Integrin αIIbβ3 and cAMP Signaling

Ulmus parvifolia Jacq. Exhibits Antiobesity Properties and Potentially Induces Browning of White Adipose Tissue

Comparison analysis of metabolite profiling in seeds and bark ofUlmus parvifolia, a Chinese medicine species

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