Anticancer and Potential Antiviral Activity of Complex Inorganic Compounds

Abstract

Recent studies indicate that viruses are associated with many types of cancerous tumors. The authors propose that complex inorganic compounds might be successfully used in the alteration of these viruses with the consequent destruction or diminution of their activity. Twenty-six complex inorganic compounds have been

Structure of 4-(4-methoxyphenyl)thiosemicarbazide

“…The antibacterial, antiviral and anticancer activities possessed by substituted thiosemicarbazides and thiosemicarbazones have generated rapidly growing interest in the chemical, biochemical and structural aspects of these compounds (Johnson, Joyner & Perry, 1952;French & Blanz, 1966;Agrawal, Booth & Sartorelli, 1968;Agrawal, Cushley, McMurray & Sartorelli, 1970;Williams, 1972;Agrawal, Booth & Sartorelli, 1973;Kuroda, Neidle & Wilman, 1984). It has been suggested that the biological activities of these groups of N,S donor ligands originate from their metal-chelating and reductive capacities (Kirschner, Wei, Francis & Bergman, 1966;Palenik, Rendle & Carter, 1974). Comparative studies of the antibacterial activity of 4-phenylthiosemicarbazide and some of its ring-substituted derivatives revealed that the activity of the para methoxy and the para chloro derivatives © 1987 International Union of Crystallography increased significantly over that of 4-phenylthiosemicarbazide (Nandi, Chaudhuri, Mazumdar & Ghosh, 1984e;present work).…”

Antibacterial Role of SO42−, NO3−, C2O42− and CH3CO2− Anions onCu(II) and Zn(II) Complexes of a Thiadiazole‐derived PyrrolylSchiff Base

“…The charge transfer band at 28665-28850 cm was assigned 32 to 2Eg 2T2g transitions possibly in an octahedral environment (Fig 2). [10][11][12][13][14] (45-64 %); +++, [14][15][16][17][18] (64-82 %); ++++, [18][19][20][21][22] (82-100 %). Percent inhibition values are relative to inhibition zone (22 mm) of the most active compound with 100 % inhibition.…”

“…These compounds possess such interesting biological properties that may be conferred to them by their strong aromatic ring system .A s ligands, they also provide many potential 12 14 binding sites for complexation and have obtained a diversified biological activity by the result of such chelation. It has been suggested 6 that the interaction of the metal ion with potentially biologically active compounds lead to destroy or greatly help to diminish [7][8][9][10][11][12][13][14][15][16][17][18][19] the role of bacteria-/virus-/cancer-associated organisms and therefore, represent a significant route for designing and establishing novel metal-based antibacterial, antiviral and anticancer therapies2. In previous works we have explored the biological properties of thiadiazole-derived compounds and the effect of chelation on their bactericidal properties2.…”

Determination and evaluation of acid dissociation constants of some novel benzothiazole Schiff bases and their reduced analogs by spectroscopy

“…[7][8][9][10] Many anticancer and antibacterial drugs are known to behave as versatile ligands, some of which exhibit increased anticancer activity when administered in the complex form with metal ions. [11][12][13] It has been suggested that certain types of cancers are caused by viruses. The interaction between the metal ion and their ligands with cancer-associated viruses might represent an important route in designing, a new anticancer therapies for tumors that become resistant to the conventional drugs.…”