Anticancer Drugs’ Deoxyribonucleic Acid (DNA) Interactions

Alotaibi, Saad H.; Momen, Awad Abdalla

doi:10.5772/intechopen.85794

Cited by 21 publications

(21 citation statements)

References 37 publications

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“…The 2dimensional molecular interaction obtained from the XP precision docking was used to assess the possible forms of bonding and non-bonding interactions between the compounds and the DNA. The result of the molecular docking studies was compared with quinacrine, a DNA-binding anticancer agent [38][39][40].…”

Section: Molecular Modelling With Dnamentioning

confidence: 99%

Biogenic Synthesis of Silver-Core Selenium-Shell Nanoparticles Using Ocimum tenuiflorum L.: Response Surface Methodology-Based Optimization and Biological Activity

2021

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Bimetallic nanoparticles (BNPs) have shown better biological potential compared to their monometallic counterparts owing to the synergistic effect produced by these alloys. In this study, selenium-capped silver nanoparticles (Ag@Se NPs) were synthesized using an Ocimum tenuiflorum extract. These BNPs were characterized using UV-visible, Fourier transform infrared spectroscopy, nanoparticle tracking analysis, electron microscopy and energy dispersive x-ray analysis. Response surface methodology was used to understand how extract volume and temperature influenced the zeta potential, hydrodynamic size and NP concentration. The phytoconstituents were identified using gas chromatography-mass spectrometry (GC-MS) and molecular docking studies were performed on B-DNA to determine possible genotoxicity. Antioxidant activities, in vitro cytotoxicity (3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay), and genotoxicity (Allium cepa root cells) of these BNPs, were also evaluated. A surface plasmon resonance band around 420 nm confirmed BNP formation with significant quantities of silver and selenium. The Ag@Se NPs displayed good stability, dispersity, antioxidant activity, and compatibility at low concentrations but showed significant cytotoxicity and genotoxicity at high concentrations. Molecular docking analysis showed weak interactions between the plant constituents and B-DNA, suggesting no genotoxicity. These results provide an insight into the conditions required for optimal production of eco-friendly Ag@Se NPs with interesting biological properties.

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Section: Molecular Modelling With Dnamentioning

confidence: 99%

Biogenic Synthesis of Silver-Core Selenium-Shell Nanoparticles Using Ocimum tenuiflorum L.: Response Surface Methodology-Based Optimization and Biological Activity

2021

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“…Sensing, bioimaging, logic gate design, and drug delivery are just a few of the many applications . Deoxyribonucleic acid (DNA) is the molecule of life and is responsible for all chemical changes in cells . Nucleoside analogues, which are enzymes involved in the synthesis of purine and pyrimidine nucleotides as well as RNA, are a common class of antimetabolites used to treat hematological malignancies .…”

Section: Introductionmentioning

confidence: 99%

“…The DNA synthesis of bacteria is inhibited by quinolone via the disruption of bacterial topoisomerase, inhibiting the catalytic activity of DNA gyrase and topoisomerase . Noncovalent interactions and hydrogen bonding, for example, occur between the nucleic acid bases and the drug, enhancing the stability of the complex . A majority of physiological processes take place in aqueous media and include various types of interactions and changes in thermodynamic parameters.…”

Section: Introductionmentioning

confidence: 99%

Elucidation of Interactions between Ciprofloxacin Hydrochloride Monohydrate and Constituents of Nucleic Acids in Aqueous Solutions at Different Temperatures

et al. 2022

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The interaction of drugs with nucleic acids is one of the most essential parts of biological research in the drug discovery and pharmaceutical development processes. Furthermore, physicochemical studies of the solution behavior of such systems are extremely desirable for elucidating the various interactions in aqueous solutions. Therefore, in this context, measurements of the density (ρ), speed of sound (u), viscosity (η), and enthalpy of dilution (q) for uracil, thymine, uridine, and thymidine in water and in aqueous solutions of ciprofloxacin hydrochloride monohydrate (Cfx) at m B (molality of Cfx in water) = (5, 10, 15, 20, 25) mmol·kg–1 across the temperature range of T = (288.15 to 318.15) K and at p = 1 × 105 Pa have been performed. Furthermore, these data have been utilized to evaluate partial molar volumes, partial molar isentropic compressions, viscosity B coefficients, standard molar enthalpies of dilution, and their corresponding transfer parameters (Δtr V 2,Φ 0, Δtr K s,2,Φ 0, Δtr B, and ΔtrΔdil H°). These properties have been used to elucidate the presence of solute–solvent interactions. The solute–Cfx interactions are exothermic in nature, according to calorimetry studies. Furthermore, the UV–visible studies show that the interactions between the pyrimidine-based molecules and drug result in a shift in wavelength (λ) as well as a change in absorption.

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“…As mentioned earlier, the study of non-covalent interactions of small molecules with DNA can help in the understanding of their mechanism of action and anticipation of the potential therapeutic significance of such interactions [ 35 ]. Estimation of the binding strength and binding mode of small molecule and DNA interactions was performed using UV/Vis, fluorescence and circular dichroism spectroscopy.…”

Section: Introductionmentioning

confidence: 99%

Biological Activity of Newly Synthesized Benzimidazole and Benzothizole 2,5-Disubstituted Furane Derivatives

et al. 2021

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Newly designed and synthesized cyano, amidino and acrylonitrile 2,5-disubstituted furane derivatives with either benzimidazole/benzothiazole nuclei have been evaluated for antitumor and antimicrobial activity. For potential antitumor activity, the compounds were tested in 2D and 3D cell culture methods on three human lung cancer cell lines, A549, HCC827 and NCI-H358, with MTS cytotoxicity and BrdU proliferation assays in vitro. Compounds 5, 6, 8, 9 and 15 have been proven to be compounds with potential antitumor activity with high potential to stop the proliferation of cells. In general, benzothiazole derivatives were more active in comparison to benzimidazole derivatives. Antimicrobial activity was evaluated with Broth microdilution testing (according to CLSI (Clinical Laboratory Standards Institute) guidelines) on Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. Additionally, Saccharomyces cerevisiae was included in testing as a eukaryotic model organism. Compounds 5, 6, 8, 9 and 15 showed the most promising antibacterial activity. In general, the compounds showed antitumor activity, higher in 2D assays in comparison with 3D assays, on all three cell lines in both assays. In natural conditions, compounds with such an activity profile (less toxic but still effective against tumor growth) could be promising new antitumor drugs. Some of the tested compounds showed antimicrobial activity. In contrast to ctDNA, the presence of nitro group or chlorine in selected furane-benzothiazole structures did not influence the binding mode with AT-DNA. All compounds dominantly bound inside the minor groove of AT-DNA either in form of monomers or dimer and higher-order aggregates.

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Anticancer Drugs’ Deoxyribonucleic Acid (DNA) Interactions

Cited by 21 publications

References 37 publications

Biogenic Synthesis of Silver-Core Selenium-Shell Nanoparticles Using Ocimum tenuiflorum L.: Response Surface Methodology-Based Optimization and Biological Activity

Biogenic Synthesis of Silver-Core Selenium-Shell Nanoparticles Using Ocimum tenuiflorum L.: Response Surface Methodology-Based Optimization and Biological Activity

Elucidation of Interactions between Ciprofloxacin Hydrochloride Monohydrate and Constituents of Nucleic Acids in Aqueous Solutions at Different Temperatures

Biological Activity of Newly Synthesized Benzimidazole and Benzothizole 2,5-Disubstituted Furane Derivatives

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