Anticancer drugs in Portuguese surface waters – Estimation of concentrations and identification of potentially priority drugs

Santos, Mónica S.F.; Franquet-Griell, Helena; Lacorte, Sı́lvia; Madeira, Luís M.; Alves, Arminda

doi:10.1016/j.chemosphere.2017.06.102

Cited by 60 publications

(24 citation statements)

References 28 publications

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“…The consumption of capecitabine decreased by one-third between the years 2013 and 2018. In comparison with global consumption, the consumption of capecitabine in Lebanon is equal to 133.09 μg Inhabitant -1 Day -1 , lower than its consumption in Portugal (206 μg μg Inhabitant -1 Day -1 ) [17], Catalonia (280 μg Inhabitant -1 Day -1 ) [24], France (213 μg Inhabitant -1 Day -1 ) [27] , and UK (183 μg Inhabitant -1 Day -1 ) [26]. As for 5-uorouracil, its consumption in Lebanon is equal to 6.69 μg Inhabitant -1 Day -1 and it is higher than its consumption in Catalonia (0.70 μg Inhabitant -1 Day -1 ) [24] and lower than Portugal (62.50 μg Inhabitant -1 Day -1 ) [17], France (71. μg Inhabitant -1 Day -1 ) [27] and UK (46 μg Inhabitant -1 Day -1 ) [26].…”

Section: Analysis Of the Resultsmentioning

confidence: 84%

“…The analysis of the toxicity of MMF and MPA each separately led to an underestimation of the risks imposed by this drug. Since MMF is a prodrug of MPA, the consumption of both was grouped using drug-speci c equivalence factors under a total MPA equivalent (table 1 [17]. As for MPA, its consumption in Lebanon equals 72.03287 μg Inhabitant -1 Day -1 , higher than in Portugal (50 μg Inhabitant -1 Day -1 ) ) [17] and Poland (51 μg Inhabitant -1 Day -1 ) [23] but lower than in Catalonia (704 μg Inhabitant -1 Day -1 ) [24].…”

Section: Analysis Of the Resultsmentioning

confidence: 99%

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Chemotherapeutic drugs in Lebanese surface waters: estimation of population exposure and identification of high-risk drugs

Saab

Nakad

Rahme

2021

Preprint

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Environmental risk assessment of anti-cancer drugs and their transformation products is a major concern worldwide due to two main factors: the consumption of chemotherapeutic agents is increasing throughout the years and conventional water treatment processes seem to be ineffective. The aim of the study is to investigate the consumption of anticancer drugs and assess their potential health hazard as contaminants of the Lebanese surface waters. Data on yearly consumption of 259 anti-neoplastic drugs over the years 2013 to 2018 were collected and the following parameters were calculated: yearly consumption of single active ingredients, yearly consumption of drug equivalents (for drugs belonging to the same pharmacologic class/ having the same active ingredient) and Predicted Environmental Concentrations (PECs). The classification of compounds into risk categories was based on exposure using PECs. The top five most commonly consumed drugs are Mycophenolate mofetil, Hydroxycarbamide, Capecitibine, Mycophenolic acid and Azathioprine. Based on the calculated PEC values of single active ingredients as well as their equivalents, six high risk priority compounds were identified: Mycophenolate mofetil, Hydroxycarbamide, Capecitibine, Mycophenolic acid and Azathioprine and 5-Fluorouracil. The impact of these micropollutants on animals as well as humans was analyzed. This research paper stresses the importance of further analysis of chemotherapy micropollutants with major focus on high risk drugs. Additionally, regulations should be set in place to ensure proper management of waste water and the development of efficient waste water treatment plants.

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Section: Analysis Of the Resultsmentioning

confidence: 84%

Section: Analysis Of the Resultsmentioning

confidence: 99%

Chemotherapeutic drugs in Lebanese surface waters: estimation of population exposure and identification of high-risk drugs

Saab

Nakad

Rahme

2021

Preprint

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“…That means that acute effects are very improbable. Despite the fact that there are not many studies on chronic toxicity, some tests showed that the concentrations detected in water were higher than the EC 50 (half maximal effective concentration) which implies that trace concentrations of anticancer drugs in the water may provoke adverse effects on the long-term or/and when they are present in a mixture (Xie 2012;Booker et al 2014;Franquet-Griell et al 2017;Santos et al 2017).…”

Section: Responsible Editor: Ester Heathmentioning

confidence: 98%

Occurrence of anticancer drugs in the aquatic environment: a systematic review

Nassour

Barton

Nabhani‐Gebara

et al. 2019

Environ Sci Pollut Res

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Water contamination with pharmaceutical products is a well-studied problem. Numerous studies have demonstrated the presence of anticancer drugs in different water resources that failed to be eliminated by conventional wastewater treatment plants. The purpose of this report was to conduct a systematic review of anticancer drugs in the aquatic environment. The methodology adopted was carried out in compliance with the PRISMA guidelines. From the 75 studies that met the specific requirements for inclusion, data extracted showed that the most common anticancer drugs studied are cyclophosphamide, tamoxifen, ifosfamide and methotrexate with concentrations measured ranging between 0.01 and 86,200 ng/L. There was significant variation in the methodologies employed due to lack of available guidelines to address sampling techniques, seasonal variability and analytical strategy. The most routinely used technique for quantitative determination was found to be solid-phase extraction followed by LC-MS analysis. The lowest reported recovery percentage was 11%, and the highest limit of detection was 1700 ng/L. This indicated the inadequacy of some methods to analyse anticancer drugs and the failure to obtain reliable results. The significant heterogeneity within methodologies made it difficult to compare results and draw conclusions, nevertheless, this study aids in the extrapolation of proposed recommendations to guide future studies and reviews.

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“…RQ < 1 indicates no ecotoxicological risk for the aquatic environment due to the effluent load. Average value data from the following: USA; Canada; France; Spain; Sweden; China; ) Greece; Taiwan; Belgium; Japan; South Africa; Portugal; India; Pakistan; Australia; and South Korea …”

Section: Introductionmentioning

confidence: 99%

Advancement in treatment of wastewater: Fate of emerging contaminants

Mohapatra

Kirpalani

2019

Can J Chem Eng

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The scarcity of industrial and domestic use water has become an important issue as industrial operations and localized pollution have burgeoned over the last decade. Wastewater (WW) treatment for recycling and reuse is gaining importance as an alternate source of water supply to circumvent water shortages. Wastewater treatment requires thorough planning, design, construction, and management of treatment facilities in order to discharge the treated water to the aquatic environment or for recycling and reuse. One detrimental effect of growing populations and urbanization has been the release of many persistent emerging contaminants (ECs) to the environment, mainly detected in WW. The entry of these ECs to the aquatic environment through wastewater treatment plants (WWTPs) may cause different ecological risks such as reproductive toxicity, endocrine disruption, and microbial resistance. The quantification of ECs (in ng or pg level) in complex matrices, such as WW samples recognized through non-target screening approaches, has played a key role in the planning and design of water treatment facilities. The purpose of this review is to provide information about advancements in wastewater treatment technologies such as constructed wetland (CW) and advanced oxidation processes (AOPs) and the fate of emerging contaminants during these treatments. Further, this review also reports the ecological effects of these contaminants and their by-products formed during various advanced WW treatment processes. The review also discusses advancements in different analytical techniques for the analysis of ECs in WW.

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Anticancer drugs in Portuguese surface waters – Estimation of concentrations and identification of potentially priority drugs

Cited by 60 publications

References 28 publications

Chemotherapeutic drugs in Lebanese surface waters: estimation of population exposure and identification of high-risk drugs

Chemotherapeutic drugs in Lebanese surface waters: estimation of population exposure and identification of high-risk drugs

Occurrence of anticancer drugs in the aquatic environment: a systematic review

Advancement in treatment of wastewater: Fate of emerging contaminants

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