Anticancer drugs in the aquatic ecosystem: Environmental occurrence, ecotoxicological effect and risk assessment

Li, Dan; Hong-xing, Chen; Liu, Hongsong; Schlenk, Daniel; Mu, Jingli; Lacorte, Sı́lvia; Ying, Guang‐Guo; Xie, Lingtian

doi:10.1016/j.envint.2021.106543

Cited by 77 publications

(35 citation statements)

References 106 publications

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“…The main categories of pharmaceuticals are also indicated, showing that neurological drugs (N) are the most consumed, followed by cardiovascular (C), alimentary tract (A), neoplastic (L), respiratory (R) or anti-infective (J), depending on the residence. This is of relevance for neurotoxic compounds as they can have negative effects on biota [ 24 ], antibiotics can be absorbed by plants upon irrigation with river or reclaimed water [ 25 ] or anticancer drugs can have chronic effects on aquatic biota [ 26 ].…”

Section: Resultsmentioning

confidence: 99%

Pharmaceutical Residues in Senior Residences Wastewaters: High Loads, Emerging Risks

2021

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Senior residences are health-care facilities that are socially-accepted for the assistance of elderly people. Since the elderly account for the foremost pharmaceutical-consuming age-group, senior residences become a hot-spot for pharmaceuticals discharge to the sewage grid. The objectives of the present study were to identify the bioactive pharmaceuticals in sewage waters from senior residences and to propose an on-site monitoring strategy for their control. In this study, we have studied the presence of 43 pharmaceuticals highly consumed by the elderly population in six senior residences located in Spain, France and Portugal. Wastewater was sampled directly from the water-chest in each residence during different times of the day throughout one week. Main compounds detected at the high µg L−1 level were analgesic and antipyretic drugs such as acetylsalicylic acid, paracetamol, ibuprofen; antibiotics such as amoxicillin and sulfamethoxazole; compounds for the treatment of neuropathies as gabapentin, trazodone and valsartan; pharmaceuticals for the treatment of diabetes (vildagliptin) and anticancer drugs. The daily loads discharged were estimated and their fate was evaluated. The final objective of this study is to highlight the need to implement at-source waste water treatment procedures in senior residences, which have been identified as a point source pollution of pharmaceuticals.

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Section: Resultsmentioning

confidence: 99%

Pharmaceutical Residues in Senior Residences Wastewaters: High Loads, Emerging Risks

2021

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“…From the application point of view, the removal of xenobiotics should be safe for the environment, and the products of their biodegradation/biotransformation should be non-toxic. Due to their cytotoxic properties, the presence of anthracycline antibiotics in the aquatic environment may pose a threat to other organisms, e.g., plants, and aquatic and soil biota [51,52]. Moreover, biodegradation of pharmaceuticals by oxidoreductases take place through different pathways and several intermediates and end-products are generated during the reaction.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Efficiency of the Removal of Cytostatic Anthracycline Drugs Using Immobilized Mycelium of Bjerkandera adusta CCBAS 930

Rybczyńska‐Tkaczyk

2021

Molecules

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The aim of this study was to evaluate the bioremoval of anthracycline antibiotics (daunomycin-DNR, doxorubicin–DOX, and mitoxantrone-MTX) by immobilized mycelium of B. adusta CCBAS 930. The activity of oxidoreductases: versatile peroxidases (VP), superoxide dismutase (SOD), catalase (CAT), and glucose oxidase (GOX), and the levels of phenolic compounds (PhC) and free radicals (SOR) were determined during the biotransformation of anthracyclines by B. adusta strain CCBAS 930. Moreover, the phytotoxicity (Lepidium sativum L.), biotoxicity (MARA assay), and genotoxicity of anthracyclines were evaluated after biological treatment. After 120 h, more than 90% of anthracyclines were removed by the immobilized mycelium of B. adusta CCBAS 930. The effective biotransformation of anthracyclines was correlated with detoxification and reduced genotoxicity.

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“…Only Steinbach et al, 2013 [19] presented data on the bioaccumulation of a pharmaceutical (verapamil) in aquatic animals (Cyprinus carpio) during early life stages. In literature, a large amount of ecotoxicological data on anticancer drugs is present [20]. Unfortunately, there are few data on acute exposure to antitumoral drugs as environmental contaminants and their effects on the aquatic species, particularly the most vulnerable forms like larvae [21].…”

Section: Introductionmentioning

confidence: 99%

Environmental Risk Assessment of Oxaliplatin Exposure on Early Life Stages of Zebrafish (Danio rerio)

Paola

Capparucci

Abbate

et al. 2022

Toxics

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Pharmaceuticals are actually identified as a threat to the ecosystem. Nowadays, the growing consumption of antineoplastic agents has been related to their continuous input in natural environments. These substances can interfere with physiological and biochemical processes of aquatic species over their entire life cycle. Oxaliplatin (OXA) is a widely used chemotherapeutic agent to treat colon or rectal cancer. This study was aimed to evaluate the developmental toxicity of the OXA exposure. To this end, zebrafish embryos were incubated with 0.001, 0.1, 0.5 mg/L OXA. At different timepoints mortality rate, hatching rate, developmental abnormalities, histological analysis, oxidative stress and mRNA expression of gene related to oxidative stress were evaluated. Our results showed that OXA exposure can induce increased mortality and developmental abnormalities reducing the hatching rate. Histological analysis demonstrated that OXA induced liver, intestine, muscle and heart injury. Superoxide dismutase and catalase activities were significantly increased after OXA exposure demonstrating its oxidative effects. The mRNA expression levels of apoptosis-related genes (caspase-3, bax and bcl-2) were significantly upregulated by OXA exposure. In conclusion, we highlighted that OXA exposure led to a dose-related developmental toxicity, oxidative stress and apoptosis.

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Anticancer drugs in the aquatic ecosystem: Environmental occurrence, ecotoxicological effect and risk assessment

Cited by 77 publications

References 106 publications

Pharmaceutical Residues in Senior Residences Wastewaters: High Loads, Emerging Risks

Pharmaceutical Residues in Senior Residences Wastewaters: High Loads, Emerging Risks

Enhanced Efficiency of the Removal of Cytostatic Anthracycline Drugs Using Immobilized Mycelium of Bjerkandera adusta CCBAS 930

Environmental Risk Assessment of Oxaliplatin Exposure on Early Life Stages of Zebrafish (Danio rerio)

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