Anticancer drugs: where are we now?

Synthesis and evaluation of sulfonamide derivatives of quinoxaline 1,4-dioxides as carbonic anhydrase inhibitors

“…27 Therefore, we adapted the previously described procedure for the preparation of the sulfamide analog 12 (Scheme 1). Initially, for their preparation, we developed a synthesis scheme starting from onitrochlorobenzene (9). Sulfochlorination of 9, followed by treatment with ammonia, yielded 4-chloro-3nitrobenzenesulfonamide (10) in high yield (Scheme 1).…”

“…5 One of the outcomes of this adjustment is the overexpression of carbonic anhydrase IX (CA IX), which is observed in tumor cells of various histogenesis. [6][7][8][9][10] Recent studies have shown that inhibiting CA IX helps overcome the resistance of tumor cells to apoptosis under hypoxic conditions. 11,12 Therefore, the design of new drugs capable of targeting cancer cells under hypoxic conditions is one of the priority directions in the development of advancing solid tumor chemotherapy.…”