Anticancer effect of HOTTIP regulates human pancreatic cancer via the metabotropic glutamate receptor 1 pathway

Ye, Yibiao; Li, Yanshan; Wei, Yunping; Xu, Yunxiuxiu; Wang, Ruomei; Fu, Zhiqiang; Zheng, Shusen; Zhou, Quanbo; Zhou, Yu; Chen, Rufu; Chen, Tao

doi:10.3892/ol.2018.8870

Cited by 6 publications

(7 citation statements)

References 32 publications

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“…HOTTIP is another HOX-dependent lncRNA that is transcribed from the 5' end of the HOXA locus. HOTTIP controls the expression of several genes by interaction with polycomb repressive complex 2 (PRC2) and mixed lineage leukemia protein-1 (MLL1)/WD repeat domain 5 (WDR5) in this locus (36,37). This lncRNA is significantly expressed in pancreatic cancer tissues and cell lines compared to normal (37).…”

Section: Hoxa Transcript At the Distal Tipmentioning

confidence: 99%

The roles of lncRNAs and miRNAs in pancreatic cancer: a focus on cancer development and progression and their roles as potential biomarkers

Jafari,

Motedayyen,

Javadi

et al. 2024

Front. Oncol.

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Pancreatic ductal adenocarcinoma (PDAC) is among the most penetrative malignancies affecting humans, with mounting incidence prevalence worldwide. This cancer is usually not diagnosed in the early stages. There is also no effective therapy against PDAC, and most patients have chemo-resistance. The combination of these factors causes PDAC to have a poor prognosis, and often patients do not live longer than six months. Because of the failure of conventional therapies, the identification of key biomarkers is crucial in the early diagnosis, treatment, and prognosis of pancreatic cancer. 65% of the human genome encodes ncRNAs. There are different types of ncRNAs that are classified based on their sequence lengths and functions. They play a vital role in replication, transcription, translation, and epigenetic regulation. They also participate in some cellular processes, such as proliferation, differentiation, metabolism, and apoptosis. The roles of ncRNAs as tumor suppressors or oncogenes in the growth of tumors in a variety of tissues, including the pancreas, have been demonstrated in several studies. This study discusses the key roles of some lncRNAs and miRNAs in the growth and advancement of pancreatic carcinoma. Because they are involved not only in the premature identification, chemo-resistance and prognostication, also their roles as potential biomarkers for better management of PDAC patients.

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Section: Hoxa Transcript At the Distal Tipmentioning

confidence: 99%

The roles of lncRNAs and miRNAs in pancreatic cancer: a focus on cancer development and progression and their roles as potential biomarkers

Jafari,

Motedayyen,

Javadi

et al. 2024

Front. Oncol.

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“…mGluR1 expression was detected in pancreatic cancer and shown to be regulated by the long non-coding RNA (lncRNA) HOXA distal transcript antisense RNA (HOTTIP) [ 133 , 134 , 135 ]. lncRNAs are byproducts of RNA polymerase II transcription, which are now understood to be important for transcriptional regulation, and this has been shown to be associated with the development of cancer [ 133 , 134 , 135 ]. In pancreatic cancer, the connection between mGluR1 and HOTTIP was suggested to be a potential prognostic marker [ 133 , 136 ].…”

Section: The Role Of Metabotropic Glutamate Receptors In Various Cancersmentioning

confidence: 99%

“…lncRNAs are byproducts of RNA polymerase II transcription, which are now understood to be important for transcriptional regulation, and this has been shown to be associated with the development of cancer [ 133 , 134 , 135 ]. In pancreatic cancer, the connection between mGluR1 and HOTTIP was suggested to be a potential prognostic marker [ 133 , 136 ]. Altered levels of HOTTIP are correlated with changes in mGluR1 expression, and these changes were linked to tumor cell viability, survival, migration, invasion, and apoptosis [ 133 , 136 ].…”

Section: The Role Of Metabotropic Glutamate Receptors In Various Cancersmentioning

confidence: 99%

“…In pancreatic cancer, the connection between mGluR1 and HOTTIP was suggested to be a potential prognostic marker [ 133 , 136 ]. Altered levels of HOTTIP are correlated with changes in mGluR1 expression, and these changes were linked to tumor cell viability, survival, migration, invasion, and apoptosis [ 133 , 136 ]. Reduced HOTTIP expression in pancreatic cells was shown to induce apoptosis.…”

Section: The Role Of Metabotropic Glutamate Receptors In Various Cancersmentioning

confidence: 99%

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Implications of a Neuronal Receptor Family, Metabotropic Glutamate Receptors, in Cancer Development and Progression

Eddy

Eddin

Fateeva

et al. 2022

Cells

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Cancer is the second leading cause of death, and incidences are increasing globally. Simply defined, cancer is the uncontrolled proliferation of a cell, and depending on the tissue of origin, the cancer etiology, biology, progression, prognosis, and treatment will differ. Carcinogenesis and its progression are associated with genetic factors that can either be inherited and/or acquired and are classified as an oncogene or tumor suppressor. Many of these genetic factors converge on common signaling pathway(s), such as the MAPK and PI3K/AKT pathways. In this review, we will focus on the metabotropic glutamate receptor (mGluR) family, an upstream protein that transmits extracellular signals into the cell and has been shown to regulate many aspects of tumor development and progression. We explore the involvement of members of this receptor family in various cancers that include breast cancer, colorectal cancer, glioma, kidney cancer, melanoma, oral cancer, osteosarcoma, pancreatic cancer, prostate cancer, and T-cell cancers. Intriguingly, depending on the member, mGluRs can either be classified as oncogenes or tumor suppressors, although in general most act as an oncogene. The extensive work done to elucidate the role of mGluRs in various cancers suggests that it might be a viable strategy to therapeutically target glutamatergic signaling.

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“…The downregulation of HOTTIP-induced apoptosis was confirmed by enhanced caspase-3/8 activity and Bax family protein expression in PC cells. In addition, mGluR1 levels also decrease with inactivation of the phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway and may also contribute to PC cell apoptosis [56]. In addition, there is evidence showing that the functional rs1859168 A>C polymorphism may decrease the risk of PC genesis by downregulating HOTTIP expression [57].…”

Section: Hottipmentioning

confidence: 99%

The multifaceted roles of long noncoding RNAs in pancreatic cancer: an update on what we know

Zhou

Chen

et al. 2020

Cancer Cell Int

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Pancreatic cancer (PC) is one of the leading causes of cancer-related deaths worldwide. Due to the shortage of effective biomarkers for predicting survival and diagnosing PC, the underlying mechanism is still intensively investigated but poorly understood. Long noncoding RNAs (lncRNAs) provide biological functional diversity and complexity in protein regulatory networks. Scientific studies have revealed the emerging functions and regulatory roles of lncRNAs in PC behaviors. It is worth noting that some in-depth studies have revealed that lncRNAs are significantly associated with the initiation and progression of PC. As lncRNAs have good properties for both diagnostic and prognostic prediction due to their translation potential, we herein address the current understanding of the multifaceted roles of lncRNAs as regulators in the molecular mechanism of PC. We also discuss the possibility of using lncRNAs as survival biomarkers and their contributions to the development of targeted therapies based on the literature. The present review, based on what we know about current research findings, may help us better understand the roles of lncRNAs in PC.

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Anticancer effect of HOTTIP regulates human pancreatic cancer via the metabotropic glutamate receptor 1 pathway

Cited by 6 publications

References 32 publications

The roles of lncRNAs and miRNAs in pancreatic cancer: a focus on cancer development and progression and their roles as potential biomarkers

The roles of lncRNAs and miRNAs in pancreatic cancer: a focus on cancer development and progression and their roles as potential biomarkers

Implications of a Neuronal Receptor Family, Metabotropic Glutamate Receptors, in Cancer Development and Progression

The multifaceted roles of long noncoding RNAs in pancreatic cancer: an update on what we know

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