Anticancer effect of myristicin on hepatic carcinoma and related molecular mechanism

Bao, Hai-Lan; Mei, Qi

doi:10.1080/13880209.2021.1961825

Cited by 16 publications

(8 citation statements)

References 34 publications

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“…In addition, it has been described as a food preservative, as it has antimicrobial activities as well as the following related activities: antioxidant, anti-inflammatory, analgesic, antiproliferative, insecticide and larvicide. However, when used in very high amounts, myristicin can have toxic effects, leading to liver degeneration and mental confusion, as it is toxic to the central nervous system [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

Chemical Profile and Biological Activities of Essential Oil from Piper arboreum for Development and Improvement of Mouthwash

et al. 2022

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Studies show that more consumers are using natural health products in the modern world. We have noticed a growing demand in markets and the professional community for mouthwashes that contain natural compounds. The objective of this study was to assess the chemical characterization and microbiological potential of the essential oil Piper arboreum (EOPa) to provide data to enable the development of a low-cost mouthwash. The evaluation of the antibacterial and bacterial resistance modulating activity was performed by the microdilution method to determine the minimum inhibitory concentration. The chemical components were characterized by gas chromatography coupled with mass spectrometry, which identified 20 chemical constituents, with caryophyllene oxide being one of the major compounds. The EOPa showed an MIC ≥ 1024 µg/mL for all bacterial strains used in the tests. When evaluating the modulating activity of EOPa combined with chlorhexidine, mouthwash and antibiotics against the bacterial resistance, the oil limited synergistic activity between the MIC of the products tested in combination (37% to 87.5%). Therefore, we recommend expanding the tests with greater variation in the EOPa concentration and the products used, as well as toxicity assessments and in vivo testing, with the purpose of the development of a possible low-cost mouthwash base that is accessible to the most vulnerable populations.

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Section: Discussionmentioning

confidence: 99%

Chemical Profile and Biological Activities of Essential Oil from Piper arboreum for Development and Improvement of Mouthwash

et al. 2022

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“…Finally, suppression of the PI3K/Akt/mTOR signaling pathway was proposed as a mode of action. 111 Myristicin (27) can also induce mitochondrialmediated apoptosis in human leukemia K562 cells in a dosedependent manner at concentrations ranging from 50 μM to 200 μM, with the release of cytochrome c and the activation of caspase-3. Additionally, PARP cleavage and DNA fragmentation (after 48 h at a concentration of 50 μM and above), with downregulation of DNA damage response genes, have been reported.…”

Section: Natural Allylic Compounds and Cancer Therapymentioning

confidence: 99%

“…Myristicin ( 27 ) is the major component of nutmeg ( Myristica fragrans ) and is found in smaller proportions in other species such as Anethum graveolens (dill) and Petroselinum crispum (parsley). Myristicin ( 27 ) is reported to have several pharmacological properties, including antioxidant, , antimicrobial, , antidiabetic, , anticancer, − anti-inflammatory, and antidepressant activities. However, when it is used in very high amounts (400 mg or more), 27 can express toxic effects, leading to liver degeneration and mental confusion, as it is toxic to the central nervous system.…”

Section: Natural Allylic Compounds and Cancer Therapymentioning

confidence: 99%

“…Myristicin ( 27 ) inhibited the EMT by increasing E -cadherin and decreasing N -cadherin expressions. Finally, suppression of the PI3K/Akt/mTOR signaling pathway was proposed as a mode of action . Myristicin ( 27 ) can also induce mitochondrial-mediated apoptosis in human leukemia K562 cells in a dose-dependent manner at concentrations ranging from 50 μM to 200 μM, with the release of cytochrome c and the activation of caspase-3.…”

Section: Natural Allylic Compounds and Cancer Therapymentioning

confidence: 99%

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From Natural Sources to Synthetic Derivatives: The Allyl Motif as a Powerful Tool for Fragment-Based Design in Cancer Treatment

et al. 2023

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Since the beginning of history, natural products have been an abundant source of bioactive molecules for the treatment of different diseases, including cancer. Many allyl derivatives, which have shown anticancer activity both in vitro and in vivo in a large number of cancers, are bioactive molecules found in garlic, cinnamon, nutmeg, or mustard. In addition, synthetic products containing allyl fragments have been developed showing potent anticancer properties. Of particular note is the allyl derivative 17-AAG, which has been evaluated in Phase I and Phase II/III clinical trials for the treatment of multiple myeloma, metastatic melanoma, renal cancer, and breast cancer. In this Perspective, we compile extensive literature evidence with descriptions and discussions of the most recent advances in different natural and synthetic allyl derivatives that could generate cancer drug candidates in the near future.

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“…[6,7] At nontoxic levels, they are reported to exhibit antiinflammatory, [8,9] antiproliferative, and anticancer effects. [10,11] Vitexin, an apigenin flavone glucoside, is a key component of several edible and medicinal plants such as pearl millet and chasteberry. [12] It has been reported to exhibit antioxidant, anticonvulsant, antiinflammatory activity, and to regulate neuroinflammation [13,14] and have antidiabetic properties.…”

Section: Introductionmentioning

confidence: 99%

Human Metabolism and Excretion of Kawakawa (Piper excelsum) Leaf Chemicals

Jayaprakash,

Pook,

Ramzan

et al. 2024

Molecular Nutrition Food Res

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ScopePiper excelsum (kawakawa) has a history of therapeutic use by Māori in Aotearoa New Zealand. It is currently widely consumed as a beverage and included as an ingredient in “functional” food product. Leaves contain compounds that are also found in a wide range of other spices, foods, and medicinal plants. This study investigates the human metabolism and excretion of kawakawa leaf chemicals.Methods and resultsSix healthy male volunteers in one study (Bioavailability of Kawakawa Tea metabolites in human volunteers [BOKA‐T]) and 30 volunteers (15 male and 15 female) in a second study (Impact of acute Kawakawa Tea ingestion on postprandial glucose metabolism in healthy human volunteers [TOAST]) consume a hot water infusion of dried kawakawa leaves (kawakawa tea [KT]). Untargeted Liquid Chromatography‐Tandem Mass spectrometry (LC‐MS/MS) analyses of urine samples from BOKA‐T identified 26 urinary metabolites that are significantly associated with KT consumption, confirmed by the analysis of samples from the independent TOAST study. Seven of the 26 metabolites are also detected in plasma. Thirteen of the 26 urinary compounds are provisionally identified as metabolites of specific compounds in KT, eight metabolites are identified as being derived from specific compounds in KT but without resolution of chemical structure, and five are of unknown origin.ConclusionsSeveral kawakawa compounds that are also widely found in other plants are bioavailable and are modified by phase 1 and 2 metabolism.

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Anticancer effect of myristicin on hepatic carcinoma and related molecular mechanism

Cited by 16 publications

References 34 publications

Chemical Profile and Biological Activities of Essential Oil from Piper arboreum for Development and Improvement of Mouthwash

Chemical Profile and Biological Activities of Essential Oil from Piper arboreum for Development and Improvement of Mouthwash

From Natural Sources to Synthetic Derivatives: The Allyl Motif as a Powerful Tool for Fragment-Based Design in Cancer Treatment

Human Metabolism and Excretion of Kawakawa (Piper excelsum) Leaf Chemicals

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