Anticancer effect of rationally designed α-helical amphiphilic peptides

Recalculating the Route: Repositioning Antimicrobial Peptides for Cancer Treatment

“…Helped by bioinformatics, studies on rational drug design and molecular docking contribute to selecting these peptides, optimizing time and cost in research. For example, the study on the rational design of an α‐helical short anti‐cancer AMP, called At1‐At12, carried out by Fangpan [42] aimed to optimize the physicochemical properties of peptide‐cell interaction and the evaluation of anticancer activity in a virulence factor of Leishmania spp. for the treatment of Melanoma Cancer [43] …”

Antifungal activity of designed α-helical antimicrobial peptides

“…Antimicrobial peptides (AMPs) or host defense peptides are naturally occurring peptides present in different organisms which are capable of killing pathogens through non-receptor-mediated membrane damage. [16][17][18][19][20][21][22][23][24] Physical damage to microbial membranes greatly reduces the chance of AMR. 19,[21][22][23][24][25][26] This advantage has drawn great attention to AMPs as novel antibiotics.…”

“…[16][17][18][19][20][21][22][23][24] Physical damage to microbial membranes greatly reduces the chance of AMR. 19,[21][22][23][24][25][26] This advantage has drawn great attention to AMPs as novel antibiotics.…”

Microfluidic Formulation of Curcumin-Loaded Multiresponsive Gelatin Nanoparticles for Anticancer Therapy

“…Cancer is a major disease that seriously affects human life and health. − At present, cancer treatment includes surgical resection, radiotherapy, and chemotherapy, and in recent years, gene therapy, , cell therapy, , photodynamic therapy, − and photothermal-ablation therapy. − Each method has its own pros and cons, and anticancer approaches combining two or more methodologies have been shown to be much more effective. , Therefore, therapeutic formulations combining multiple treatment methods are more promising for the future of anticancer therapies.…”