Anticancer Effect of Rutin Isolated from the Methanolic Extract of Triticum aestivum Straw in Mice

Dixit, Savita

doi:10.3390/medsci2040153

Cited by 22 publications

(15 citation statements)

References 17 publications

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“…Several anticancer drugs, such as vincristine, etoposide, vinblastine, irinotecan, paclitaxel (taxol) and topotecan are botanical secondary metabolites or semi-synthetic derivatives ( 1 ). Apigenin ( 2 ), deguelin ( 3 ), kaempferol ( 4 ), luteolin ( 5 – 7 ), quercetin ( 8 – 11 ), rutin ( 12 – 16 ), tricin ( 17 ), xanthomicrol ( 18 ), α-copaene ( 19 ), α-humulene ( 20 , 21 ) and β-himachalene ( 22 ) are some botanical ingedients that have been investigated as possible future remedies for use in chemotherapy. Xanthomicrol and calycopterin have also been shown to exert potent inhibitory effects on microvessel outgrowth and that these anti-angiogenic effects enhance the antitumor activity ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

“…α-humulene (16.7%), γ-himachalene (10.1) and β-himachalene (46.6%) were found to be the main constituents and they all exhibited anticancer activity ( 31 ). Flavonoids as botanical ingredients exhibit a wide range of biological effects, such as anticancer activities ( 5 , 12 , 35 ). Luteolin and tricin are two flavonoids that are isolated from Cyperus longus ( 30 ), and they have been reported to possess cytotoxic activity against cancer cell lines ( 6 , 7 , 17 ).…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the cytotoxic effects of Cyperus longus extract, fractions and its essential oil on the PC3 and MCF7 cancer cell lines

et al. 2015

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Cyperus longus is one of the Iranian endemic species. However, to date, and to the best of our knowledge, there are no availale academic reports on the cytotoxicity of this plant. Thus, this study was carried out to examine the in vitro anti-proliferative and anti-apoptotic effects of Cyperus longus extract, fractions and essential oil (EO) on MCF7 and PC3 cell lines. The chemical constituents of EO were identified using gas chromatography (GC)-mass spectrometry (MS) analysis. The cells were cultured in RPMI-1640 medium and incubated with various concentrations of the plant extract and fractions. Cell viability was quantified by MTT assay following 24, 48 and 72 h of exposure to (12.5–200 µg/ml) of the methanol extract, the dichloromethane (CH2Cl2), ethyl acetate (EtOAc) and water fractions, as well as the EO of the plant. The percentage of apoptotic cells was determined using propidium iodide staining of DNA fragments by flow cytometry (sub-G1 peak). The most effective fraction in the MCF7 cell line was the CH2Cl2 fraction (IC50 after 48 h, 25.34±2.01). The EtOAc fraction (IC50 after 48 h, 35.2±2.69) and the methanol extract (IC50 after 48 h, 64.64±1.64) were also found to be effective. The IC50 values obtained for the PC3 cell line were 37.97±3.87, 51.57±3.87 and 70.33±2.36 for the CH2Cl2 fraction, the EtOAc fraction and the methanol extract, respectively. Based on these data and due to the partial polarity of the most effective fraction (the CH2Cl2 fraction), we also examined the cytotoxicity of the plant EO. The IC50 values after 48 h were 22.25±4.25 and 12.55±3.65 in the PC3 and MCF7 cell lines, respectively. DNA fragmentation assay also confirmed these data. Performing GC-MS analysis for the plant EO revealed that β-himachalene (10.81%), α-caryophyllene oxide (7.6%), irisone (4.78%), β-caryophyllene oxide (4.36%), humulene oxide (12%), viridiflorol (4.73%), aristolone (6.39%) and longiverbenone (6.04%) were the main constituents. Our results demonstrated that two of the constituents of Cyperus longus, viridiflorol and longiverbenone, should be investigated further as possible promising chemotherapeutic agents in cancer treatment.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of the cytotoxic effects of Cyperus longus extract, fractions and its essential oil on the PC3 and MCF7 cancer cell lines

et al. 2015

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“…Isorhamnetin is an O-methylated flavonol, which is also reported in apple extract [24] and Ginkgo biloba [25] and exhibited neuronal differentiation in cell line model. Rutin is reported to demonstrate broad range of biological activities such as antimicrobial, anti-inflammatory, antioxidant, neuroprotective, antiviral, anti-ulcer and anti-cancer activities [26] . Pectolinarin is a flavnone heteroside reported to be present in Bignoneaceae family members with anti-oxidant, antiinflammatory and hepatoprotective activities [27] .…”

Section: Resultsmentioning

confidence: 99%

Antioxidant Activity and Phytochemical Composition of Aqueous Extract of Markhamia lutea (Benth) K. Schum. Leaves

Brindha¹,

Ragamanvitha²,

Rajendran³

et al. 2017

TJNPR

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“…Calzada et al (2018) have reported that rutin obtained from showed Schinus molle anticancer activity against human leukemic monocyte lymphoma U-937 cell line. Rutin isolated from the methanolic extract of straw has shown the anticancer and Triticum aestivum chemopreventive effect of rutin in dimethylbenz[a]anthracene (DMBA) and croton oil-induced skin carcinogenesis in Swiss albino mice (Dixit, 2014). In a different type of study, rutin encapsulated in low methoxyl pectin beads was found to exhibit anti-cancer activity higher than non-encapsulated rutin against three human cancer cell lines i.e.…”

Section: Anticancer Propertymentioning

confidence: 99%

A review on the chemistry and biological properties of Rutin, a promising nutraceutical agent

Prasad¹,

Prasad²

2019

Asian J Pharm Pharmacol

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Nature is an attractive source of new therapeutic agents and a variety of phytochemicals have proved to be very valuable in the prevention and treatment of various diseases. Many of the important drugs isolated from plants during the past 50 years have revolutionized modern medicinal practice (Dar et al., 2017). The use of herbal medicines and phytonutrients or nutraceuticals continues to expand rapidly across the world with many people now resorting to these products for the treatment of various health challenges in different national healthcare settings (WHO, 2004). It is estimated that up to 80% of the world's population living in the developing countries rely on herbal medicinal products as a primary source of healthcare and traditional medical practice as an integral part of the culture in their communities (Ekor, 2013). The medicinal compounds derived from various plants could be divided into three major biochemical classes: alkaloids (vinblastine, vincristine, pilocarpine, berberine, caffeine, piperine etc.), flavonoids (quercetin, kaempferol, chrysin, naringenin, genistein, rutin etc.) and terpenoids (artemisinin, taxol, digitoxin, azadarachtin, camphor, limonene etc.) (Takshak, 2018). These compounds have also gained importance in the area of nutraceuticals, which have positive health effects and may prove to be advantageous in the treatment of diseases like cancer, cardiovascular diseases and diabetes (Crozier et

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Anticancer Effect of Rutin Isolated from the Methanolic Extract of Triticum aestivum Straw in Mice

Cited by 22 publications

References 17 publications

Evaluation of the cytotoxic effects of Cyperus longus extract, fractions and its essential oil on the PC3 and MCF7 cancer cell lines

Evaluation of the cytotoxic effects of Cyperus longus extract, fractions and its essential oil on the PC3 and MCF7 cancer cell lines

Antioxidant Activity and Phytochemical Composition of Aqueous Extract of Markhamia lutea (Benth) K. Schum. Leaves

A review on the chemistry and biological properties of Rutin, a promising nutraceutical agent

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