2024
DOI: 10.3892/ol.2024.14752
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Anticancer effect of the oncolytic Newcastle disease virus harboring the PTEN gene on glioblastoma

Seonhee Kim,
Bo-Kyoung Jung,
Jinju Kim
et al.

Abstract: Glioblastoma (GBM) is one of the most lethal types of human brain cancer and is characterized by rapid growth, an aggressive nature and a poor prognosis. GBM is highly heterogeneous, and often involves several genetic mutations and abnormalities. Genetic disorders or low expression of phosphatase and tensin homolog (PTEN) are associated with GBM occurrence, progression and poor prognosis of patients with GBM. However, effective delivery of PTEN for expression in GBM cells within the brain remains challenging. … Show more

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