Anticancer effects of acteoside: Mechanistic insights and therapeutic status

Khan, Rasel Ahmed; Hossain, Rajib; Roy, Pranta; Jain, Divya; Saikat, Abu Saim Mohammad; Shuvo, Anik Prasad Roy; Akram, Muhammad; Elbossaty, Walaa Fikry; Khan, Ishaq N.; Painuli, Sakshi; Semwal, Prabhakar; Rauf, Abdur; Islam, Muhammad Torequl; Khan, Haroon

doi:10.1016/j.ejphar.2021.174699

Cited by 26 publications

(17 citation statements)

References 98 publications

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“…The anti-cancer effects of AC have been reviewed that it exhibits anti-angiogenesis, anti-proliferation, anti-invasion, anti-metastasis, and apoptosis-promotion in various cancers [11] . AC has been shown cellular toxicity to cancer cells independently of the status of p53, Rb1, and H-Ras by mediating many signaling pathways, including anti-oxidant, immune, and proteostatic system.…”

Section: Anti-cancersmentioning

confidence: 99%

“…The neuroprotective activity of AC is also reported by inhibiting the activity of NF-κB signaling in Aβ-treated N2a cells [10] . Recently, the reviews on AC have been studied [1] , [2] , [11] , [12] , [13] . For example, Khan [11] focuses on the anticancer activity of AC.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, the reviews on AC have been studied [1] , [2] , [11] , [12] , [13] . For example, Khan [11] focuses on the anticancer activity of AC. Srivastava [12] reports the comprehensive review of phytochemistry and pharmacology of Duranta erecta Linn, which can be a significant source of AC.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, Srivastava also discusses some pharmacological activities of AC [12] . From the sophisticate literature research, we find that AC has been reported various pharmacological activities, including anti-oxidation [14] , anti-inflammation [15] , anti-cancer [11] , neuroprotection [16] , cardiovascular protection [17] , anti-diabetes [18] , bone and cartilage protection [19] , hepatoprotection [20] , and anti-microorganism [21] . In this review, we will mainly focus on these fields and summarize the research progress of AC, including the pharmacokinetic profiles.…”

Section: Introductionmentioning

confidence: 99%

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The pharmacokinetic property and pharmacological activity of acteoside: A review

Xiao¹,

Ren²,

Wu³

2022

Biomedicine & Pharmacotherapy

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Section: Anti-cancersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The pharmacokinetic property and pharmacological activity of acteoside: A review

Xiao¹,

Ren²,

Wu³

2022

Biomedicine & Pharmacotherapy

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“…These properties could be attributed to the high content of phenylethanoid glycosides (14.9 ± 0.4 mg/g and 15.4 ± 0.3 for the infusion and hydroethanolic extract, respectively). These compounds have been recently described to exert many different biological properties, including anticancer and anti-inflammatory activities [ 56 , 57 ]. Although the extract contains more phenylethanoid glycosides than the infusion, this is the one that presents the best results.…”

Section: Resultsmentioning

confidence: 99%

From Tradition to Health: Chemical and Bioactive Characterization of Five Traditional Plants

et al. 2022

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Several scientific studies have been proving the bioactive effects of many aromatic and medicinal plants associated with the presence of a high number of bioactive compounds, namely phenolic compounds. The antioxidant, anti-inflammatory, and antimicrobial capacities of these molecules have aroused high interest in some industrial sectors, including food, pharmaceuticals, and cosmetics. This work aimed to determine the phenolic profiles of the infusions and hydroethanolic extracts of five plants (Carpobrotus edulis, Genista tridentata, Verbascum sinuatum, Cytisus multiflorus, and Calluna vulgaris) that have been employed in many traditional preparations. In addition, the antioxidant, antimicrobial, anti-inflammatory, and anti-tumoral activity of each different preparation was evaluated using in vitro assays. The HPLC-DAD-ESI/MS profile revealed the presence of eighty phenolic compounds, belonging to seven different families of compounds. Regarding antioxidant properties, the hydroethanolic extract of C. edulis showed a potent effect in the TBARS assay (IC50 = 1.20 µg/mL), while G. tridentata hydroethanolic extract achieved better results in the OxHLIA test (IC50 = 76 µg/mL). For cytotoxic and anti-inflammatory results, V. sinuatum infusions stood out significantly, with GI50 = 59.1–92.1 µg/mL and IC50 = 121.1 µg/mL, respectively. Finally, C. edulis hydroethanolic extract displayed the most relevant antibacterial activity, showing MBC values of 0.25–1 mg/mL, while G. tridentata hydroethanolic extract exerted the greatest antifungal effects (MFC of 0.5–1 mg/mL). The results of this study deepen the knowledge of the phenolic profiles and also provide evidence on the bioactive properties of the species selected, which could be considered highly valuable options for research and application in several sectors, namely food, cosmetics, and pharmaceuticals.

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Unraveling the Dual Anti‐Inflammatory and Antioxidant Mechanisms of Acteoside: Computational Insights and Experimental Validation

Muhtar,

Ylham,

Tiemuer

et al. 2024

Chemistry & Biodiversity

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Acteoside (ACT) is one of the primary bioactive ingredients in Cistanche tubulosa (Schenk). Its remarkable efficacy in treating immune‐related and inflammatory disorders has garnered significant interest among scientific circles. However, the anti‐inflammatory and antioxidant effects of ACT and its underlying molecular mechanisms require further investigation. In this study, pharmacophore‐based reverse docking and molecular dynamics simulations identified potential anti‐inflammatory targets in silico. Studies conducted in vitro with lipopolysaccharide (LPS)‐induced RAW264.7 cells validated the anti‐inflammatory properties of ACT. Methyl thiazolyl tetrazolium (MTT) and lactate dehydrogenase (LDH) assays indicated ACT's non‐toxic and growth‐promoting effects on cells. ACT significantly reduced nitric oxide (NO) and reactive oxygen species (ROS) production and restored levels of antioxidant enzymes. It also decreased pro‐inflammatory cytokines. Western blotting assays indicated that ACT inhibited p38, TNF‐α, PI3K/AKT, and NF‐κB signaling pathways. These findings underscore ACT's ability to mitigate acute inflammation in RAW264.7 cells by modulating key signaling pathways and provide the scientific basis for enhancing the medicinal value of ACT and future drug development.

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Anticancer effects of acteoside: Mechanistic insights and therapeutic status

Cited by 26 publications

References 98 publications

The pharmacokinetic property and pharmacological activity of acteoside: A review

The pharmacokinetic property and pharmacological activity of acteoside: A review

From Tradition to Health: Chemical and Bioactive Characterization of Five Traditional Plants

Unraveling the Dual Anti‐Inflammatory and Antioxidant Mechanisms of Acteoside: Computational Insights and Experimental Validation

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