Anticancer effects of bifidobacteria on colon cancer cell lines

Faghfoori, Zeinab; Faghfoori, Mohammad Hasan; Saber, Amir; Izadi, Azimeh; Khosroushahi, Ahmad Yari

doi:10.1186/s12935-021-01971-3

Cited by 46 publications

(32 citation statements)

References 48 publications

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“…lactis (68.07%) and B. animalis subsp. animalis (68.3%) [ 145 ]. In a recent review, an advantage of Bifidobacterial strains as potential vectors for novel anti-cancer therapies was suggested due to their anaerobic and non-pathogenic nature, this species would have the ability to grow in necrotic tumour tissue while not posing an infectious threat to potentially vulnerable patients receiving bacterial-based treatments [ 146 ].…”

Section: Microbial Cytotoxic Genes With Therapeutic Potentialmentioning

confidence: 99%

The impact of the human microbiome in tumorigenesis, cancer progression, and biotherapeutic development

et al. 2022

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Background Cancer impacts millions of lives globally each year, with approximately 10 million cancer-related deaths recorded worldwide in 2020. Mounting research has recognised the human microbiome as a key area of interest in the pathophysiology of various human diseases including cancer tumorigenesis, progression and in disease outcome. It is suggested that approximately 20% of human cancers may be linked to microbes. Certain residents of the human microbiome have been identified as potentially playing a role, including: Helicobacter pylori, Fusobacterium nucleatum, Escherichia coli, Bacteroides fragilis and Porphyromonas gingivalis. Main body In this review, we explore the current evidence that indicate a link between the human microbiome and cancer. Microbiome compositional changes have been well documented in cancer patients. Furthermore, pathogenic microbes harbouring specific virulence factors have been implicated in driving the carcinogenic activity of various malignancies including colorectal, gastric and pancreatic cancer. The associated genetic mechanisms with possible roles in cancer will be outlined. It will be indicated which microbes have a potential direct link with cancer cell proliferation, tumorigenesis and disease progression. Recent studies have also linked certain microbial cytotoxins and probiotic strains to cancer cell death, suggesting their potential to target the tumour microenvironment given that cancer cells are integral to its composition. Studies pertaining to such cytotoxic activity have suggested the benefit of microbial therapies in oncological treatment regimes. It is also apparent that bacterial pathogenic protein products encoded for by certain loci may have potential as oncogenic therapeutic targets given their possible role in tumorigenesis. Conclusion Research investigating the impact of the human microbiome in cancer has recently gathered pace. Vast amounts of evidence indicate the human microbiome as a potential player in tumorigenesis and progression. Promise in the development of cancer biomarkers and in targeted oncological therapies has also been demonstrated, although more studies are needed. Despite extensive in vitro and in vivo research, clinical studies involving large cohorts of human patients are lacking. The current literature suggests that further intensive research is necessary to validate both the role of the human microbiome in cancer, and the use of microbiome modification in cancer therapy.

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Section: Microbial Cytotoxic Genes With Therapeutic Potentialmentioning

confidence: 99%

The impact of the human microbiome in tumorigenesis, cancer progression, and biotherapeutic development

et al. 2022

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“…Since probiotics and their postbiotics can modify the intestinal microbiota, e.g., by increasing the number of lactobacilli and bifidobacteria, they influence the process of colon carcinogenesis. This is possible through several mechanisms, which were discussed in detail in our previous review [ 7 ] and examples of which include the following [ 4 , 7 ]: Antiproliferative activity—according to many studies, both probiotics and postbiotics demonstrate antiproliferative activity against cancer cell lines [ 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. It can manifest through the activity of mitochondrial dehydrogenases.…”

Section: Introductionmentioning

confidence: 99%

“…Antiproliferative activity—according to many studies, both probiotics and postbiotics demonstrate antiproliferative activity against cancer cell lines [ 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. It can manifest through the activity of mitochondrial dehydrogenases.…”

Section: Introductionmentioning

confidence: 99%

Anticancer Potential of Post-Fermentation Media and Cell Extracts of Probiotic Strains: An In Vitro Study

Nowak

Zakłos‐Szyda

Rosicka‐Kaczmarek

et al. 2022

Cancers

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Background: Lactic acid bacteria (LAB), many of which are probiotics, can produce health-promoting metabolites (postbiotics). Purpose: To assess the mechanism of antiproliferative action of postbiotics, post-fermentation media (PFM) and cell extracts (CEs) of several strains of LAB were studied against colon (Caco-2), and cervix (HeLa) cancer cell lines, as well as normal intestine (IEC-6) cells, were used as a comparison. Methods: Postbiotics of various LAB (n = 39) were screened for their antiproliferative activity. The effect of PFM and CEs on reactive oxygen species (ROS), mitochondrial membrane potential (MMP), ATP production, phosphatidylserine (PS) externalisation, and apoptosis-related caspases 3/7 and 9 activation was assayed. Results: PFM and CEs showed strong dose-dependent antiproliferative activity against Caco-2 cells, up to 77.8 ± 0.8% and 58.4 ± 1.6% for PFM and CEs, respectively. Stronger inhibitory activity against cancerous (Caco-2 and HeLa) cells than against normal (IEC-6) cells was observed. PFM were more inhibitory than CEs, and both generated oxidative stress in Caco-2 cells. PFM of L. plantarum 0991 and L. brevis 0983 induced apoptosis in Caco-2 cells by the mitochondrial signalling pathway. Conclusions: Anticancer activity of PFM and CEs of LAB, as well as the ability of apoptosis induction, is strain-specific.

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“…Peptostreptococcus anaerobius exhibits the activity on activating the PCWBR2-integrin a2/b1-PI3K-Akt-NFkB axis throughout CRC occurrence, which was considered a potential therapeutic target toward CRC [ 9 ]. In contrast, the supplementation of probiotics, including Bifidobacterium , Lactobacillus genera, or Clostridium butyricum , was demonstrated to improve clinical prognosis or suppress development of CRC via lessening of CRC-associated signaling or manipulating gut microbiota [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Exploring Gut Microenvironment in Colorectal Patient with Dual-Omics Platform: A Comparison with Adenomatous Polyp or Occult Blood

Wei

Huang

et al. 2022

Biomedicines

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The gut mucosa is actively absorptive and functions as the physical barrier to separate the gut ecosystem from host. Gut microbiota-utilized or food-derived metabolites are closely relevant to the homeostasis of the gut epithelial cells. Recent studies widely suggested the carcinogenic impact of gut dysbiosis or altered metabolites on the development of colorectal cancer (CRC). In this study, liquid chromatography coupled-mass spectrometry and long-read sequencing was applied to identify gut metabolites and microbiomes with statistically discriminative abundance in CRC patients (n = 20) as compared to those of a healthy group (n = 60) ofenrolled participants diagnosed with adenomatous polyp (n = 67) or occult blood (n = 40). In total, alteration in the relative abundance of 90 operational taxonomic units (OTUs) and 45 metabolites were identified between recruited CRC patients and healthy participants. Among the candidates, the gradual increases in nine OTUs or eight metabolites were identified in healthy participants, patients diagnosed with occult blood and adenomatous polyp, and CRC patients. The random forest regression model constructed with five OTUs or four metabolites achieved a distinct classification potential to differentially discriminate the presence of CRC (area under the ROC curve (AUC) = 0.998 or 0.975) from the diagnosis of adenomatous polyp (AUC = 0.831 or 0.777), respectively. These results provide the validity of CRC-associated markers, including microbial communities and metabolomic profiles across healthy and related populations toward the early screening or diagnosis of CRC.

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Anticancer effects of bifidobacteria on colon cancer cell lines

Cited by 46 publications

References 48 publications

The impact of the human microbiome in tumorigenesis, cancer progression, and biotherapeutic development

The impact of the human microbiome in tumorigenesis, cancer progression, and biotherapeutic development

Anticancer Potential of Post-Fermentation Media and Cell Extracts of Probiotic Strains: An In Vitro Study

Exploring Gut Microenvironment in Colorectal Patient with Dual-Omics Platform: A Comparison with Adenomatous Polyp or Occult Blood

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