Anticancer effects of olive oil polyphenols and their combinations with anticancer drugs

Torić, Jelena; Marković, Ana; Brala, Cvijeta Jakobušić; Barbarić, Monika

doi:10.2478/acph-2019-0052

Cited by 58 publications

(41 citation statements)

References 112 publications

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“…Besides, the easy modification of the allows their association with other antitumor drugs and molecules that can target specifics cells, such as cancer cells 89 . Researchers have been reported the beneficial effects of the combination between anticancer agents and polyphenols 90 , 91 , as well as compounds found in BRP 92 – 94 . Qiao et al 95 showed that green tea catechins associated with antitumor drugs are more effective than monotherapy.…”

Section: Resultsmentioning

confidence: 99%

Biosynthesis and characterization of gold nanoparticles using Brazilian red propolis and evaluation of its antimicrobial and anticancer activities

Botteon

Silva

Ccana-Ccapatinta

et al. 2021

Sci Rep

165

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Gold nanoparticles (AuNPs) are highlighted due to their low toxicity, compatibility with the human body, high surface area to volume ratio, and surfaces that can be easily modified with ligands. Biosynthesis of AuNPs using plant extract is considered a simple, low-cost, and eco-friendly approach. Brazilian Red Propolis (BRP), a product of bees, exhibits anti-inflammatory, anti-tumor, antioxidant, and antimicrobial activities. Here, we described the biosynthesis of AuNPs using BRP extract (AuNPextract) and its fractions (AuNPhexane, AuNPdichloromethane, AuNPethyl acetate) and evaluated their structural properties and their potential against microorganisms and cancer cells. AuNPs showed a surface plasmon resonance (SPR) band at 535 nm. The sizes and morphologies were influenced by the BRP sample used in the reaction. FTIR and TGA revealed the involvement of bioactive compounds from BRP extract or its fractions in the synthesis and stabilization of AuNPs. AuNPdichloromethane and AuNPhexane exhibited antimicrobial activities against all strains tested, showing their efficacy as antimicrobial agents to treat infectious diseases. AuNPs showed dose-dependent cytotoxic activity both in T24 and PC-3 cells. AuNPdichloromethane and AuNPextract exhibited the highest in vitro cytotoxic effect. Also, the cytotoxicity of biogenic nanoparticles was induced by mechanisms associated with apoptosis. The results highlight a potential low-cost green method using Brazilian red propolis to synthesize AuNPs, which demonstrated significant biological properties.

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Section: Resultsmentioning

confidence: 99%

Biosynthesis and characterization of gold nanoparticles using Brazilian red propolis and evaluation of its antimicrobial and anticancer activities

Botteon

Silva

Ccana-Ccapatinta

et al. 2021

Sci Rep

165

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“…of the 80% alcoholic extract of olive leaves, containing oleuropein, HT, caffeic acid, tyrosol, apigenin, and verbascoside [26,27]. Biophenols can also be used to develop new drugs useful to combat chronic inflammatory conditions, the risk of thrombosis, CVD-related states such as atherosclerosis [28], cancer [29], also in combination with anti-cancer drugs [30], as well as to reduce amyloid deposition associated with T2DM and aging-related states such as neurodegeneration [1,31] ( Figure 1). Finally, the molecular scaffolds of plant polyphenols are also investigated to develop new molecules potentially exploitable in disease prevention and therapy [32].…”

Section: Polyphenols: Important Players Of the Mediterranean/asian Dietsmentioning

confidence: 99%

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Leri

Scuto

Ontario

et al. 2020

IJMS

329

213

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The increasing extension in life expectancy of human beings in developed countries is accompanied by a progressively greater rate of degenerative diseases associated with lifestyle and aging, most of which are still waiting for effective, not merely symptomatic, therapies. Accordingly, at present, the recommendations aimed at reducing the prevalence of these conditions in the population are limited to a safer lifestyle including physical/mental exercise, a reduced caloric intake, and a proper diet in a convivial environment. The claimed health benefits of the Mediterranean and Asian diets have been confirmed in many clinical trials and epidemiological surveys. These diets are characterized by several features, including low meat consumption, the intake of oils instead of fats as lipid sources, moderate amounts of red wine, and significant amounts of fresh fruit and vegetables. In particular, the latter have attracted popular and scientific attention for their content, though in reduced amounts, of a number of molecules increasingly investigated for their healthy properties. Among the latter, plant polyphenols have raised remarkable interest in the scientific community; in fact, several clinical trials have confirmed that many health benefits of the Mediterranean/Asian diets can be traced back to the presence of significant amounts of these molecules, even though, in some cases, contradictory results have been reported, which highlights the need for further investigation. In light of the results of these trials, recent research has sought to provide information on the biochemical, molecular, epigenetic, and cell biology modifications by plant polyphenols in cell, organismal, animal, and human models of cancer, metabolic, and neurodegenerative pathologies, notably Alzheimer’s and Parkinson disease. The findings reported in the last decade are starting to help to decipher the complex relations between plant polyphenols and cell homeostatic systems including metabolic and redox equilibrium, proteostasis, and the inflammatory response, establishing an increasingly solid molecular basis for the healthy effects of these molecules. Taken together, the data currently available, though still incomplete, are providing a rationale for the possible use of natural polyphenols, or their molecular scaffolds, as nutraceuticals to contrast aging and to combat many associated pathologies.

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“…In human colon cancer DLD1 cells, hydroxytyrosol induced cell apoptosis, and the activation of PIPK3/AKT pathway through ROS production [44]. Accordingly, incubation with the only extract obtained from OWW, at the highest concentration, significantly increased the generation of ROS, which might be useful to activate specific intracellular signals leading to cell death as already shown by others [44,45]. Furthermore, we found that at the highest concentration level, incubation with the extract obtained from OP reduced cell viability.…”

Section: Discussionmentioning

confidence: 71%

Antioxidant Efficacy of Olive By-Product Extracts in Human Colon HCT8 Cells

Centrone

D’Agostino

Difonzo

et al. 2020

Foods

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The production of olive oil is accompanied by the generation of a huge amount of waste and by-products including olive leaves, pomace, and wastewater. The latter represents a relevant environmental issue because they contain certain phytotoxic compounds that may need specific treatments before the expensive disposal. Therefore, reducing waste biomass and valorizing by-products would make olive oil production more sustainable. Here, we explore the biological actions of extracts deriving from olive by-products including olive pomace (OP), olive wastewater (OWW), and olive leaf (OLs) in human colorectal carcinoma HCT8 cells. Interestingly, with the same phenolic concentration, the extract obtained from the OWW showed higher antioxidant ability compared with the extracts derived from OP and OLs. These biological effects may be related to the differential phenolic composition of the extracts, as OWW extract contains the highest amount of hydroxytyrosol and tyrosol that are potent antioxidant compounds. Furthermore, OP extract that contains a higher level of vanillic acid than the other extracts displayed a cytotoxic action at the highest concentration. Together these findings revealed that phenols in the by-product extracts may interfere with signaling molecules that cross-link several intracellular pathways, raising the possibility to use them for beneficial health effects.

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Anticancer effects of olive oil polyphenols and their combinations with anticancer drugs

Cited by 58 publications

References 112 publications

Biosynthesis and characterization of gold nanoparticles using Brazilian red propolis and evaluation of its antimicrobial and anticancer activities

Biosynthesis and characterization of gold nanoparticles using Brazilian red propolis and evaluation of its antimicrobial and anticancer activities

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Antioxidant Efficacy of Olive By-Product Extracts in Human Colon HCT8 Cells

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