Anticancer effects of thymoquinone in head and neck squamous cell carcinoma: A scoping review

Kwan, Kera; Han, Albert Y.; Mukdad, Laith; Barragan, Frida; Selim, Omar; Alhiyari, Yazeed; St. John, Maie

doi:10.1002/lio2.1097

Cited by 2 publications

(2 citation statements)

References 83 publications

(269 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thymoquinone, the main constituent of N. sativa , inhibits the proliferation, migration, and invasion and induces apoptosis by inhibiting the PI3K/Akt pathway activity in KB cell lines [ 23 ]. Thymoquinone is reported to have modified the PI3k/Akt pathway through reduced phosphorylation, also it leads to upregulation of tumor suppressor protein phosphatase and tensin homolog (PTEN) [ 24 ]. It is reported that thymoquinone at different concentrations reduced neuroinflammation by inhibiting TNF-α, IL-1β inflammatory mediators nitric oxide, and prostaglandin E2 (PGE2).…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Targeting of Nerve Growth Factor by Thymoquinone and Cuscutin: A Molecular Dynamics Simulation Study

Begum,

Ramadoss,

Yadalam

et al. 2024

Cureus

View full text Add to dashboard Cite

Background Nerve growth factor (NGF) is a novel target of pain therapeutics for oral cancer, and it plays a main role in the nociception of chronic pain. Surgery, along with chemotherapy or radiotherapy, is the gold standard for treating patients, but the side effects are significant as well. Newer effective interventions with natural phytochemicals could improve patient compliance and enhance the quality of life among patients with oral cancer. A literature search revealed a positive correlation between NGF and oral cancer pain. Nigella sativa ( N. sativa ) and Cuscuta reflexa ( C. reflexa ) have proven anticancer effects, but their activity with NGF is unexplored. Aims and objectives We aimed to identify the potential phytochemicals in N. sativa and C. reflexa . We also checked the NGF-blocking activity of the phytochemicals. Molecular docking and molecular dynamic (MD) simulations evaluated the binding energy and stability between the NGF protein and selected phytochemical ligands. Materials and methods We obtained protein NGF structure from UniProt (ID: 4EDX, P01138, Beta-nerve growth factor), ligand (thymoquinone) structure using PubChem ID: 10281, and ligand (cuscutin) structure using PubChem ID: 66065. Maestro protein (Schrödinger Inc., Mannheim, Germany) was used for molecular docking. Desmond Simulation Package (Schrödinger Inc., Mannheim, Germany) was used to model MD for 100 nanoseconds (ns). We have assessed the interaction between the protein and ligands by root mean square deviation (RMSD) values. Results The interaction of thymoquinone and cuscutin with NGF was assessed. While interacting with thymoquinone, there was mild fluctuation from 0.6 Å to 2.5 Å up to 80 ns and ended up at 4.8 Å up to 100 ns. While interacting with cuscutin, mild fluctuation was seen from 0.8 Å to 4.8 Å till 90 ns and ended at 6.4 Å up to 100 ns. We found a stable interaction between our drug combination and the NGF receptor. Conclusion We have identified a stable interaction between thymoquinone, cuscutin, and NGF by our MD simulations. Hence, it could be used as an NGF inhibitor for pain relief and to control tumor progression. Further in vitro and in vivo evaluations of this novel drug combination with phytochemicals will help us understand their biological activities and potential clinical applications in oral cancer therapeutics.

show abstract

Section: Discussionmentioning

confidence: 99%

Phytochemical Targeting of Nerve Growth Factor by Thymoquinone and Cuscutin: A Molecular Dynamics Simulation Study

Begum,

Ramadoss,

Yadalam

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…The primary outcome measure was the size of the lesion at 3 months post-treatment compared to the initial dimensions. Although the study was completed in 2020, the results have not yet been published [ 156 , 157 ].…”

Section: Tq and Colorectal Cancermentioning

confidence: 99%

Potential anticancer properties and mechanisms of thymoquinone in colorectal cancer

Sheikhnia,

Rashidi,

Maghsoudi

et al. 2023

Cancer Cell Int

View full text Add to dashboard Cite

Colorectal neoplasms are one of the deadliest diseases among all cancers worldwide. Thymoquinone (TQ) is a natural compound of Nigella sativa that has been used in traditional medicine against a variety of acute/chronic diseases such as asthma, bronchitis, rheumatism, headache, back pain, anorexia, amenorrhea, paralysis, inflammation, mental disability, eczema, obesity, infections, depression, dysentery, hypertension, gastrointestinal, cardiovascular, hepatic, and renal disorders. This review aims to present a detailed report on the studies conducted on the anti-cancer properties of TQ against colorectal cancer, both in vitro and in vivo. TQ stands as a promising natural therapeutic agent that can enhance the efficacy of existing cancer treatments while minimizing the associated adverse effects. The combination of TQ with other anti-neoplastic agents promoted the efficacy of existing cancer treatments. Further research is needed to acquire a more comprehensive understanding of its exact molecular targets and pathways and maximize its clinical usefulness. These investigations may potentially aid in the development of novel techniques to combat drug resistance and surmount the obstacles presented by chemotherapy and radiotherapy. Graphical Abstract

show abstract

Anticancer effects of thymoquinone in head and neck squamous cell carcinoma: A scoping review

Cited by 2 publications

References 83 publications

Phytochemical Targeting of Nerve Growth Factor by Thymoquinone and Cuscutin: A Molecular Dynamics Simulation Study

Phytochemical Targeting of Nerve Growth Factor by Thymoquinone and Cuscutin: A Molecular Dynamics Simulation Study

Potential anticancer properties and mechanisms of thymoquinone in colorectal cancer

Contact Info

Product

Resources

About