Anticancer potential of <i>Ferula assa-foetida </i>and its constituents, a powerful plant for cancer therapy

Sirizi, Mohammad Amin Ghaffari; Ghalenoei, Jalil Alizadeh; Allahtavakoli, Mohammad; Forouzanfar, Hasan; Bagheri, Seyyed Majid

doi:10.4331/wjbc.v14.i2.28

Cited by 7 publications

(7 citation statements)

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“…Assa-foetida is an OGR obtained from the Ferula assa-foetida L. root that is used traditionally as an analgesic, sexual aphrodisiac, anticonvulsant, and anthelmintic agent [17].…”

Section: Discussionmentioning

confidence: 99%

“…Assa-foetida is an OGR obtained from the Ferula assa-foetida L. root that is used traditionally as an analgesic, sexual aphrodisiac, anticonvulsant, and anthelmintic agent [17]. New studies have reported that this Ferula assa-foetida L. OGR has relaxant, antiviral, anticonvulsant, antidementia, antimutagenic, anti-inflammatory, antidiabetic, antifungal, and particularly, antitumor activities [17]. Its antitumor potential is owing to the identified main compounds including sulfide and glycoside compounds, coumarin derivatives, and various terpenoids [23].…”

Section: Discussionmentioning

confidence: 99%

“…[14], Hibiscus sabdariffa [15], Aloe vera, and Aloe arborescens extracts [16] In the Middle East and Asia, more than 85% of the population uses herbal medicine for disease management [11]. Ferula assa-foetida L. belongs to the family Apiaceace and is an important Ferula species used in traditional medicine for some reproductive system diseases, nervous problems, digestive diseases, and some tumors [17]. The main plant bioactive compound is oleo-gum-resin (OGR), which is extracted from the roots and stems [18].…”

Section: Introductionmentioning

confidence: 99%

“…Its extracts contain major antioxidant compounds including phenolic compounds like diterpenes, phenolic acids (cinnamic and benzoic acids derivatives), tocopherols, flavonoids, and carotenoids [20]. Assa-foetida OGR is traditionally used as an analgesic, sexual aphrodisiac, anticonvulsant, and anthelmintic agent [17]. In various tumors, the cytotoxic and anticancer effects of Ferula assa-foetida L. have been studied [17,21].…”

Section: Introductionmentioning

confidence: 99%

“…Assa-foetida OGR is traditionally used as an analgesic, sexual aphrodisiac, anticonvulsant, and anthelmintic agent [17]. In various tumors, the cytotoxic and anticancer effects of Ferula assa-foetida L. have been studied [17,21].…”

Section: Introductionmentioning

confidence: 99%

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Antitumor and Phytochemical Properties of Ferula assa-foetida L. Oleo-Gum–Resin against HT-29 Colorectal Cancer Cells In Vitro and in a Xenograft Mouse Model

Elarabany,

Hamad,

Alzamel

2023

Molecules

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Colorectal cancer (CRC) is one of the most frequently occurring tumors. Ferula assa-foetida oleo-gum–resin (OGR) extract is a traditional cooking spice known for its broad spectrum of biological activities such as antifungal, antiparasitic, and anti-inflammatory activities. This study evaluated the antitumor effect of OGR extract against HT-29 colorectal cancer cells. The OGR chemical composition was analyzed using LC–ESI–MS/MS; MTT, clonogenic assays, and a xenograft model were used to measure cytotoxicity, while apoptotic proteins were detected using Western blotting. Phytochemical analysis revealed that the extract was a rich source of isoflavones, xanthones, and other derivatives. In a dose-dependent manner, the OGR extract significantly inhibited colony formation ability and HT-29 cell growth (IC50 was 3.60 ± 0.02 and 10.5 ± 0.1 mg/mL, respectively). On the other hand, the OGR extract significantly induced apoptosis and increased the expression of some pro-death proteins involved in cellular apoptosis including PUMA, BIM, BIK, and BAK. Moreover, in a subcutaneous HT-29 xenograft model, the tumor volume and burden decreased after treatment with the OGR extract (550 ± 32 mm3 and 16.3 ± 3.6, respectively) This study demonstrated that Ferula assa-foetida OGR ethanolic extract has potential antitumor effects against HT-29 CRC cell lines by reducing cell viability and the function of apoptosis. More studies are needed to reveal the underlying mechanisms related to cytotoxicity and apoptosis induction.

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“…Assa-foetida is an OGR obtained from the Ferula assa-foetida L. root that is used traditionally as an analgesic, sexual aphrodisiac, anticonvulsant, and anthelmintic agent [17].…”

Section: Discussionmentioning

confidence: 99%