Anticancer potential of natural peptides from terrestrial and marine environments: A review

Eghtedari, Masoumeh; Porzani, Samaneh Jafari; Nowruzi, Bahareh

doi:10.1016/j.phytol.2021.02.008

Cited by 39 publications

(30 citation statements)

References 161 publications

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“…This peptide is selective to cancerous cells and is non-hemolytic, making it a promising peptide for oncological treatment [110]. Particularly, the ChMAP-28 peptide shows the capacity to provoke necrosis in cancer cells through plasmatic membrane disruption [7]. Several studies on its properties have discovered that this peptide resulted in cytotoxicity for A431 epidermoid carcinoma, HL-60 acute promyelocytic leukemia, and SKBR-3 human breast adenocarcinoma cells [97].…”

Section: Chmap-28mentioning

confidence: 99%

“…Isolated from the venom of the Oreumenes decoratus wasp, decoralin-NH2 is another peptide that has demonstrated both antimicrobial and anticancer properties [111]. Specifically, decoralin-NH2 is capable of provoking necrosis through membrane micellization [112] in breast cancer (MCF-7) and sarcoma cells [7]. Reportedly, several analogs and modifications have been made to decoralin-NH2, which have shown similar anticancer activity but even less hemolysis [113,114].…”

Section: Decoralin-nh2mentioning

confidence: 99%

“…Hepcidin is a peptide obtained from tilapia fish (Oreochromis mossambicus) [115]. Specifically, two of its isoforms, TH1-5 and TH2-3, have denoted cytotoxic effects [7]. TH1-5 changed the lipid membrane and induced necrosis in high concentrations and apoptosis in lower concentrations [116].…”

Section: Hepcidinmentioning

confidence: 99%

“…The recently proposed alternatives are notably represented by hybrid molecules coupled with conventional chemotherapy drugs [5], computer-aided drug discovery [6], and bioactive peptides [7]. Precisely, peptides have shown a trend for performing as therapeutics against cancer cells when obtained from native proteins [8].…”

Section: Introductionmentioning

confidence: 99%

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Natural Peptides Inducing Cancer Cell Death: Mechanisms and Properties of Specific Candidates for Cancer Therapeutics

2021

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Nowadays, cancer has become the second highest leading cause of death, and it is expected to continue to affect the population in forthcoming years. Additionally, treatment options will become less accessible to the public as cases continue to grow and disease mechanisms expand. Hence, specific candidates with confirmed anticancer effects are required to develop new drugs. Among the novel therapeutic options, proteins are considered a relevant source, given that they have bioactive peptides encrypted within their sequences. These bioactive peptides, which are molecules consisting of 2–50 amino acids, have specific activities when administered, producing anticancer effects. Current databases report the effects of peptides. However, uncertainty is found when their molecular mechanisms are investigated. Furthermore, analyses addressing their interaction networks or their directly implicated mechanisms are needed to elucidate their effects on cancer cells entirely. Therefore, relevant peptides considered as candidates for cancer therapeutics with specific sequences and known anticancer mechanisms were accurately reviewed. Likewise, those features which turn certain peptides into candidates and the mechanisms by which peptides mediate tumor cell death were highlighted. This information will make robust the knowledge of these candidate peptides with recognized mechanisms and enhance their non-toxic capacity in relation to healthy cells and further avoid cell resistance.

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Section: Chmap-28mentioning

confidence: 99%

Section: Decoralin-nh2mentioning

confidence: 99%

Section: Hepcidinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Natural Peptides Inducing Cancer Cell Death: Mechanisms and Properties of Specific Candidates for Cancer Therapeutics

2021

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“…Despite the signi cant development in biomedical eld, cancer remains ambiguous especially from the therapeutic perspective and one of the greatest challenges to mankind (Silva et al 2019). It is evident that AMPs derived from marine fungi have signi cant pharmacological activities and act as a cancer suppressant (Eghtedari et al 2021).…”

Section: Introductionmentioning

confidence: 99%

Production Optimization and In Vitro Evaluation of Anti-Proliferative, Anti-Oxidant and Anti-Inflammatory Potential of the Antibacterial Peptide MAFP9

Raghavan

Pannippara²,

Kesav

et al. 2021

Preprint

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Peptides are important natural bioactive agents obtained from various sources including microbes, plants and animals. The present study involved the optimization and physicochemical characterization of an antibacterial peptide MFAP9 produced by a marine fungus Aspergillus fumigatus BTMF9 and its vitro evaluation of antiproliferative, antioxidant and anti-inflammatory potential. Antiproliferative activity was performed using A549 lung carcinoma and normal L929 fibroblast cell lines employing MTT assay method. Antioxidant activity was assessed using DPPH assay and Cox2 inhibition assay of peptide treated LPS stimulated THP1 cell lines was used for anti-inflammatory studies. The results of in vitro antiproliferative activity assessment showed that MFAP9 was cytotoxic with an IC50 value of 29 µg/mL towards A549 cells. Fluorescence microscopic analysis revealed apoptotic features such as chromatin condensation and alterations in the size and the shape of cells after treatment with MFAP9 at a concentration 50 µg/mL. The DPPH radical scavenging activity of MFAP9 exhibits reasonably higher scavenging activity compared to that of standard antioxidant at same concentration level. Moreover, MFAP9 showed significant anti-inflammatory activities. Time course experiment was conducted with the Czapek- Dox medium and optimized the rate of MFAP9 production. The study on various physico-chemical parameters on the stability revealed that the maximum active temperature of MAFP9 is 50oC, stable in basic pH and 1 mM concentration of Ni2+, Cd2+ and Mg2+ promotes the peptide activity. Hopefully, by employing the advancements in proteomics, bioinformatics, and modification strategies, MFAP9 could emerge as novel promising therapeutic drug in future for various clinical applications.

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From Sea to Cell: Marine Peptides as Key Players in siRNA-Mediated Cancer Therapy

Alfaray,

Amalia,

Ali

et al. 2024

Interdisciplinary Cancer Research

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Anticancer potential of natural peptides from terrestrial and marine environments: A review

Cited by 39 publications

References 161 publications

Natural Peptides Inducing Cancer Cell Death: Mechanisms and Properties of Specific Candidates for Cancer Therapeutics

Natural Peptides Inducing Cancer Cell Death: Mechanisms and Properties of Specific Candidates for Cancer Therapeutics

Production Optimization and In Vitro Evaluation of Anti-Proliferative, Anti-Oxidant and Anti-Inflammatory Potential of the Antibacterial Peptide MAFP9

From Sea to Cell: Marine Peptides as Key Players in siRNA-Mediated Cancer Therapy

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