Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues

Costa, David G.; Rangel, Luciana P.; Martins-Dinis, Mafalda Maria D. C.; Ferretti, Giulia Diniz da Silva; Ferreira, Vı́tor F.; Silva, Jerson L.

doi:10.3390/molecules25040893

Cited by 58 publications

(32 citation statements)

References 157 publications

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“…Another study also confirmed a radioprotective role of epicatechin in human keratinocyte HaCaT cells and in Sprague-Dawley rats via ROS regulation and JNK and p38 pathway alterations [227]. [228][229][230]. ARQ 761, a β-lapachone analogue, has completed a phase I clinical trial (clinical trial number: NCT01502800) in advanced solid tumors.…”

Section: Polyphenolsmentioning

confidence: 75%

“…β -Lapachone (3,4-dihydro-2,2-dimethyl-2H-naphthol (1,2-b) pyran-5,6-dione (C 15 H 14 O 3 )) is a natural naphthoquinone, originally an isomer of lapacho, obtained from the bark of the purple Ipe in South America. Various studies have demonstrated that β -lapachone can induce cell death in solid cancers including esophageal and oral cancers [ 228 – 230 ]. ARQ 761, a β -lapachone analogue, has completed a phase I clinical trial (clinical trial number: NCT01502800 ) in advanced solid tumors.…”

Section: Natural Herbs Effectively Modulating Ros Are Important Drmentioning

confidence: 99%

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ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer

Huang

Pan

2020

Oxidative Medicine and Cellular Longevity

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Head and neck cancer is a highly genetic and metabolic heterogeneous collection of malignancies of the lip, oral cavity, salivary glands, pharynx, esophagus, paranasal sinuses, and larynx with five-year survival rates ranging from 12% to 93%. Patients with head and neck cancer typically present with advanced stage III, IVa, or IVb disease and are treated with comprehensive modality including chemotherapy, radiotherapy, and surgery. Despite advancements in treatment modality and technique, noisome recurrence, invasiveness, and resistance as well as posttreatment complications severely influence survival rate and quality of life. Thus, new therapeutic strategies are urgently needed that offer enhanced efficacy with less toxicity. ROS in cancer cells plays a vital role in regulating cell death, DNA repair, stemness maintenance, metabolic reprogramming, and tumor microenvironment, all of which have been implicated in resistance to chemo-/radiotherapy of head and neck cancer. Adjusting ROS generation and elimination to reverse the resistance of cancer cells without impairing normal cells show great hope in improving the therapeutic efficacy of chemo-/radiotherapy of head and neck cancer. In the current review, we discuss the pivotal and targetable redox-regulating system including superoxide dismutases (SODs), tripeptide glutathione (GSH), thioredoxin (Trxs), peroxiredoxins (PRXs), nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/keap1), and mitochondria electron transporter chain (ETC) complexes and their roles in regulating ROS levels and their clinical significance implicated in chemo-/radiotherapy of head and neck cancer. We also summarize several old drugs (referred to as the non-anti-cancer drugs used in other diseases for a long time) and small molecular compounds as well as natural herbs which effectively modulate cellular ROS of head and neck cancer to synergize the efficacy of conventional chemo-/radiotherapy. Emerging interdisciplinary techniques including photodynamic, nanoparticle system, and Bio-Electro-Magnetic-Energy-Regulation (BEMER) therapy are promising measures to broaden the potency of ROS modulation for the benefit of chemo-/radiotherapy in head and neck cancer.

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Section: Polyphenolsmentioning

confidence: 75%

Section: Natural Herbs Effectively Modulating Ros Are Important Drmentioning

confidence: 99%

ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer

Huang

Pan

2020

Oxidative Medicine and Cellular Longevity

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“…Specifically, a certain association has been observed between alcohol consumption and the risk of developing different types of cancer, regardless of the amount consumed [15]. On the other hand, some authors have reported that alcohol consumption is associated with a decreased incidence of cancer because of its stilbenoid content [16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Wine Intake in the Framework of a Mediterranean Diet and Chronic Non-Communicable Diseases: A Short Literature Review of the Last 5 Years

2020

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Dietary habits are a determining factor of the higher incidence and prevalence of chronic non-communicable diseases (NCDs). In the aim to find a possible preventive and intervention strategy, the Mediterranean diet (MedDiet) has been proposed as an effective approach. Within the MedDiet, moderate wine consumption with meals is a positive item in the MedDiet score; however, recent studies have reported a dose-response association between alcohol consumption and higher risk of a large number of NCDs. This review aimed to evaluate the association between NCDs and wine consumption in the framework of the MedDiet, with a simple review of 22 studies of the highest-level literature published over the last five years. We found that the information regarding the effects of wine in different health outcomes has not varied widely over the past five years, finding inconclusive results among the studies evaluated. Most of the literature agrees that light to moderate wine intake seems to have beneficial effects to some extent in NCDs, such as hypertension, cancer, dyslipidemia and dementia, but no definitive recommendations can be made on a specific dose intake that can benefit most diseases.

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“…However, due to rapid and extensive metabolism, its bioavailability is poor. A growing body of evidence indicates that various chemical modifications may significantly improve resveratrol's bioavailability and potency against different types of cancer [12]. Mayhoub and co-workers replaced the trans stilbene ethylenic bridge of the resveratrol scaffold with a 1,2,4-thiadiazole heterocycle and next modified the substituents on the two aromatic rings and evaluated cytotoxicity of these compounds against human breast cancer MCF-7 cell line.…”

Section: Derivatives Of 124-thiadiazolementioning

confidence: 99%

Thiadiazole derivatives as anticancer agents

Szeliga

2020

Pharmacol. Rep

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In spite of substantial progress made toward understanding cancer pathogenesis, this disease remains one of the leading causes of mortality. Thus, there is an urgent need to develop novel, more effective anticancer therapeutics. Thiadiazole ring is a versatile scaffold widely studied in medicinal chemistry. Mesoionic character of this ring allows thiadiazole-containing compounds to cross cellular membrane and interact strongly with biological targets. Consequently, these compounds exert a broad spectrum of biological activities. This review presents the current state of knowledge on thiadiazole derivatives that demonstrate in vitro and/or in vivo efficacy across the cancer models with an emphasis on targets of action. The influence of the substituent on the compounds’ activity is depicted. Furthermore, the results from clinical trials assessing thiadiazole-containing drugs in cancer patients are summarized.

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Anticancer Potential of Resveratrol, β-Lapachone and Their Analogues

Cited by 58 publications

References 157 publications

ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer

ROS-Mediated Therapeutic Strategy in Chemo-/Radiotherapy of Head and Neck Cancer

Wine Intake in the Framework of a Mediterranean Diet and Chronic Non-Communicable Diseases: A Short Literature Review of the Last 5 Years

Thiadiazole derivatives as anticancer agents

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