Anticancer ruthenium(ii) tris(pyrazolyl)methane complexes with bioactive co-ligands

Abstract

In comparison with RuII-arene compounds, the medicinal potential of homologous RuII-tpm compounds [tpm = tris(pyrazolyl)methane] is underexplored. Pyridine, 4-pyridinemethanol and four functionalized pyridines, synthesized from the esterification of 4-pyridinemethanol with...

Cyclopentadienyl Molybdenum(II) Compounds Bearing Ether and Thioether Functions in the Side Chain: Synthesis, Characterization, and Cytotoxic/Cytostatic Studies

“…This study described synthesis of new cyclopentadienyl and indenyl molybdenum compounds bearing N,N-chelating ligands with cytostatic activity improved by a targeted modification of the coordinated ligands. All synthesized final products (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) were characterized by NMR spectroscopy, infrared spectroscopy, mass spectrometry and elemental analysis. X-ray diffraction analysis was used for determination of crystal structures of…”

“…In the case of complexes bearing 5-NH 2 phen (11) and bq (12), hydrogen atoms of the Cp ring seem to be non-equivalent, as elucidated form four signals appearing in the region 5.63-5.71 ppm. Lower molecular symmetry is also evident from the signals of methylene groups.…”

“…Cytotoxic effects of synthesized molybdenum (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) were evaluated against human T-lymphocytic leukemia cells MOLT-4 in the exponential growth phase and 24 h of treatment. We note that our working group uses this suspension cell line as "standard cancer line" for preliminary evaluation of the cytotoxicity of transition metal complexes.…”

“…Promising results were also demonstrated on ruthenium(II) tris(pyrazolyl)methane complexes bearing congeners of flurbiprofen, ibuprofen and naproxen. They were found to be active against the ovarian cancer cell lines A2780 and A2780cisR [11] …”

“…They were found to be active against the ovarian cancer cell lines A2780 and A2780cisR. [11] Series of ruthenium(II), iridium(III), rhenium(I) and osmium(II) complexes were designed for photodynamic therapy. For instance, osmium phenanthroline complex exhibits a 3.6×10 5 fold increase in cytotoxicity upon visible light irradiation toward melanoma cells while being low toxic in vivo in mice.…”