Anticancerous potential of polysaccharides sequentially extracted from Polygonatum cyrtonema Hua in Human cervical cancer Hela cells

Li, Ling; Thakur, Kiran; Cao, Yu-Yao; Liao, Bu-Yan; Zhang, Jianguo; Wei, Zhao‐Jun

doi:10.1016/j.ijbiomac.2020.01.223

Cited by 60 publications

(21 citation statements)

References 36 publications

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“…In traditional Chinese medicine clinical practice, Huangjing has multiple effects: invigorating Qi and nourishing Yin, moistening the lungs, invigorating the spleen, and benefiting the kidneys. Modern pharmaceutical research has shown that Huangjing has been used for the treatment of delaying aging, enhancing immunity, anti-fatigue effects, lowering blood sugar, anti-tumor effects, protecting the cardiovascular system, and improving memory ( Zhang et al, 2018b ; Zhao et al, 2018b ; Li et al, 2020 , 2021b ) and has enormous potential in the treatment of COVID-19 ( Mu et al, 2021 ). From ancient times, Huangjing has also been used as food, such as several well-received sweetmeats, functional beverages, and fruit wine ( Li et al, 2021c ).…”

Section: Introductionmentioning

confidence: 99%

An Evaluation of Traits, Nutritional, and Medicinal Component Quality of Polygonatum cyrtonema Hua and P. sibiricum Red.

Yin

Bai

et al. 2022

Front. Plant Sci.

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Polygonati rhizoma (Huangjing in Chinese) is a traditional and classic dual-purpose material used in food and medicine. Herbalists in China and Japan have noticed several different rhizome types in Huangjing with different qualities. Rhizome of Polygonatum cyrtonema Hua and P. sibiricum Red. is divided into five types: “Jitou-type” Polygonati rhizoma (JTPR), atypical “Jitou-type” Polygonati rhizoma (AJTPR), “Jiang-type” Polygonati rhizoma (JPR), “Cylinder-type” Polygonati rhizoma (CPR), and “Baiji-type” Polygonati rhizoma (BJPR). This study observed the microstructure and histochemical localization of polysaccharides, saponins, and proteins in Huangjing. Nutritional and medicinal component data and antioxidant capacity (DPPH and ABTS) were analyzed to evaluate the quality of different types of Huangjing. The results showed that the comprehensive quality of the rhizomes, BJPR and JTPR, was better, regardless of their nutritional or medicinal values. Altogether, these results could recommend future breeding efforts to produce Huangjing with improved nutritional and medicinal qualities.

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Section: Introductionmentioning

confidence: 99%

An Evaluation of Traits, Nutritional, and Medicinal Component Quality of Polygonatum cyrtonema Hua and P. sibiricum Red.

Yin

Bai

et al. 2022

Front. Plant Sci.

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“…Hence, Lin et al provided evidence that the Scleromitrion diffusum polysaccharide (SDP) in high doses inhibited tumor growth by apoptosis such as cisplastin-positive drugs [ 75 ]. In addition, Li et al found that Polygonatum cyrtonema Hua polysaccharide induced Hela cell inhibition of proliferation by regulating the cell cycle and different apoptosis pathway-related genes [ 76 ]. In our attempt to understand the mechanism by which WCCPSs induce inhibition of growth, we performed an apoptosis assay.…”

Section: Discussionmentioning

confidence: 99%

Anti-Cancerous Potential of Polysaccharides Derived from Wheat Cell Culture

et al. 2022

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There is a global need to discover effective anti-cancerous compounds from natural sources. Cultivated wheat cells can be a valuable source of non-toxic or low toxic plant-derived polysaccharides. In this study, we evaluated the anti-cancer ability of seven fractions of wheat cell culture polysaccharides (WCCPSs) in the HCT-116 colon cancer cell line. Almost all (6/7) fractions had an inhibitory effect on the proliferation of colon cancer cells, and two fractions (A-b and A-f) had considerable therapeutic indexes. The WCCPS fractions induced cell cycle arrest in the G1 phase and induced different rates of apoptosis (≤48%). Transmission and scanning electron microscopy revealed that WCCPS fractions caused apoptotic changes in the nucleus and cytoplasm, including damage to mitochondria and external morphological signs of apoptosis. In addition, the WCCPSs induced an increase in the levels of Bax, cytochrome c, and caspases 8 and 3, indicating that cell death progressed through intrinsic and extrinsic pathways of apoptosis. Furthermore, some fractions caused a significant decrease of c-Myc, b-catenin, NFkB2, and HCAM (CD 44) levels, indicating enhanced cell differentiation. Thus, for the first time, our results provide a proof of concept of the anti-cancer capacity of WCCPS fractions in colorectal cancer.

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“…Li et al. (2020a,2020b) found that after ameliorating dyslipidaemia and metabolic endotoxaemia, the Artemisia sphaerocephala Krasch polysaccharide (ASKP) could significantly alleviate HFD‐induced obesity in mice. Different relative gene expression analyses indicated that the ASKP administration modulated hepatic lipid metabolism and downregulated related genes, including ACC‐1, FAS, SREBP‐1c and PPARc.…”

Section: Introductionmentioning

confidence: 99%

Structural analysis and anti‐obesity effect of Polygonatum cyrtonema polysaccharide against obesity induced by high‐fat diet in mice

Liang

Kai³

et al. 2021

Int J of Food Sci Tech

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This study aimed to analyse the physicochemical properties of Polygonatum cyrtonema polysaccharide (PCP) and evaluated its effects in a high‐fat diet (HFD)‐induced obese mice. Experimentally, PCP was established as a homogeneous heteropolysaccharide with both α‐ and β‐configurations, and its estimated average molecular weight was ˜5.1 kDa. Besides, we discovered its major monosaccharides, including galactose, mannose, rhamnose, galacturonic acid and glucose. PCP markedly decreased obesity‐related parameters, improved serum lipid profile, fasting blood glucose, and leptin levels and reversed insulin resistance. It also reduced the hepatic infiltration of lipid droplets and the size of adipocytes in adipose tissues. Finally, PCP simulation significantly downregulated the mRNA expression of CCAAT/enhancer‐binding protein‐α (C/EBPα), peroxisome proliferator‐activated receptor‐γ (PPARγ), sterol regulatory element‐binding protein‐1c (SREBP‐1c) and fatty acid synthase (FAS). On the contrary, it increased carnitine palmitoyltransferase (CPT1) and uncoupling protein 2 (UCP2) levels closely related to thermogenesis and glucolipid metabolism. Taken together, these findings have provided evidence that PCP could be a potential anti‐obesity ingredient in preventing diet‐induced obesity.

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Anticancerous potential of polysaccharides sequentially extracted from Polygonatum cyrtonema Hua in Human cervical cancer Hela cells

Cited by 60 publications

References 36 publications

An Evaluation of Traits, Nutritional, and Medicinal Component Quality of Polygonatum cyrtonema Hua and P. sibiricum Red.

An Evaluation of Traits, Nutritional, and Medicinal Component Quality of Polygonatum cyrtonema Hua and P. sibiricum Red.

Anti-Cancerous Potential of Polysaccharides Derived from Wheat Cell Culture

Structural analysis and anti‐obesity effect of Polygonatum cyrtonema polysaccharide against obesity induced by high‐fat diet in mice

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