Anticandidal activity of certain South Indian medicinal plants

Vaijayanthimala, J.; Anandi, C.; Udhaya, V.; Pugalendi, Kodukkur Viswanathan

doi:10.1002/(sici)1099-1573(200005)14:3<207::aid-ptr564>3.0.co;2-i

Cited by 36 publications

(25 citation statements)

References 7 publications

(5 reference statements)

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“…Furthermore, Candida species other than C. albicans have, in recent years, shown to be responsible for fungemia. C. parapsilosis, C. tropicalis, and C. glabrata infections are more common now than before [4].Since the antimycotic activity of plants remains largely unexplored, interest has grown in the search for anticandidal agents from plants [5]. Our group has previously reported on the occurrence of over 5.000 natural compounds with anticandidal activity [6].…”

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Essential oils of three species of Heracleum. Anticandidal activity

İşcan

Özek

et al. 2004

Chem Nat Compd

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Fruits of Heracleum crenatifolium Boiss., Heracleum sphondylium L. subsp. ternatum (Velen.) Brummitt, and Heracleum platytaenium Boiss. (Umbelliferae) were hydrodistilled to obtain essential oils that were then analyzed by GC and GC/MS. The major component was identified as octyl acetate (93.7, 87.6 and 31.6% respectively). Octyl butyrate was also characterized as the main component in H. platytaenium oil. Furthermore, anticandidal activity of the oils was evaluated using the microdilution broth method. All the oils showed good inhibitory effects against C. glabrata.A rapid increase is observed in the number of Candida infections on people with compromised immune systems such as cancer and AIDS patients. Infections are usually difficult to eradicate completely in patients receiving antifungal agents continuously for long periods of time [1,2]. Anticandidal drugs such as fluconazole have been reported to cause resistance [3].Previously, antifungal resistance used to be rare on Candida species; however, at present resistance is a very serious problem. Furthermore, Candida species other than C. albicans have, in recent years, shown to be responsible for fungemia. C. parapsilosis, C. tropicalis, and C. glabrata infections are more common now than before [4].Since the antimycotic activity of plants remains largely unexplored, interest has grown in the search for anticandidal agents from plants [5]. Our group has previously reported on the occurrence of over 5.000 natural compounds with anticandidal activity [6].Here we report on anticandidal effects of the fruit essential oils of Heracleum crenatifolium Boiss., Heracleum sphondylium L. subsp. ternatum (Velen.) Brummitt, and Heracleum platytaenium Boiss. Heracleum crenatifolium is an endemic plant and this is the first report on its essential oil composition and anticandidal activity. The essential oils were analyzed using both gas chromatography (GC) and gas chromatography/mass spectroscopy (GC/MS) techniques.The composition and relative percentages of individual components of the oil were determined by chromatographic and spectroscopic means. Major components were identified as octyl acetate (93.7, 87.6 and 31.6% respectively) for each essential oil. In the oil of H. platytaenium, octyl butyrate (37.8%) was the main component. Complete GC/MS analysis of the oils will be reported elsewhere [9]. Main components in the oils are shown in Table 2. Results of anticandidal assays are given in Table 3.The essential oils did not show outstanding inhibitory effect. They showed moderate activity (MIC values 0.25 to 1.0 mg/mL) against most Candida species. However, their effect was close to that of the standard antifungal agent ketoconazole on Candida dubliniensis and Candida glabrata. The anticandidal effects were better expressed on C. glabrata.Our group has previously reported on the antimicrobial activity of H. sphondylium subsp. ternatum (collected from another region) essential oil that has 1-octanol (50.3%) as the main component [10]. The oil was shown to inhibit Can...

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“…Since the antimycotic activity of plants remains largely unexplored, interest has grown in the search for anticandidal agents from plants [5]. Our group has previously reported on the occurrence of over 5.000 natural compounds with anticandidal activity [6].…”

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confidence: 99%

Essential oils of three species of Heracleum. Anticandidal activity

İşcan

Özek

et al. 2004

Chem Nat Compd

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“…The ethanolic extract of the roots and also the whole plant excluding roots of M. koenigii, however, did not show any antifungal activity against Cryptococcus neoformans, Trichophyton mentagrophytes and Microsporum canis 36,37 . Aqueous and ethanolic extracts of M. koenigii were evaluated for the anti candidal activity against the 30 candida albicans, in that no extract exhibited any anticandidal activity 38 .…”

Section: Antifungal Activitymentioning

confidence: 99%

Murraya koenigii

Saini¹

2013

IOSR-JPBS

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“…The aqueous residue was then placed in an oven 45°C for about 48 h to remove the water. The final product was dissolved in 1% DMSO (dimethyl sulfoxide) to yielding a concentration of 400 mg/ml for subsequent experimentation (Vaijayanthimala et al, 2000). The solvent was used as the negative control (1% aqueous DMSO).…”

Section: Preparation Of Ethanol Extractsmentioning

confidence: 99%

Antibacterial activity of plant extracts against oral and skin pathogens

Alipour¹,

Khanmohammadi²

2011

Afr. J. Microbiol. Res.

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The aim of this study is to examine the antibacterial activity of plant extracts. Both broth dilution and disc diffusion methods were used to assess the antibacterial activity of these extracts against skin and oral pathogens. Eryngium caucaseum Trautv, Eryngium bungei Boiss and Adiantum capillus-veneris have shown antibacterial activity against Streptococcus pyogenes, Streptococcus mutans, Staphylococcus aureus and Streptococcus sanguis. E. caucaseum Trautv showed the highest inhibition zone (> 30 mm) against S. pyogenes. The growth of S. pyogenes was remarkably inhibited by the ethanolic extract of the three plant extracts.

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Anticandidal activity of certain South Indian medicinal plants

Cited by 36 publications

References 7 publications

Essential oils of three species of Heracleum. Anticandidal activity

Essential oils of three species of Heracleum. Anticandidal activity

Murraya koenigii

Antibacterial activity of plant extracts against oral and skin pathogens

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