Anticarcinogenic activity of Withania somnifera Dunal against Dalton’s Ascitic Lymphoma

Christina, A. J. M.; Joseph, Dhanish; Packialakshmi, M; Ramalingam, Kothai; Robert, Séverine; Chidambaranathan, N.; Ramasamy, M.

doi:10.1016/j.jep.2004.04.004

Cited by 58 publications

(28 citation statements)

References 8 publications

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“…3a) suggest that this compound was able to restrict DL development in mice. The range of reduction observed in ascitic volume is comparable with a ∼2 times reduction caused by the extract of a macrofungus [42] and ∼50% reduction in tumor weight by the extract of Withania somnifera [43]. Reports are scanty on Ru-complex induced regression of lymphoma in vivo.…”

Section: Discussionmentioning

confidence: 69%

Regression of Dalton’s lymphoma in vivo via decline in lactate dehydrogenase and induction of apoptosis by a ruthenium(II)-complex containing 4-carboxy N-ethylbenzamide as ligand

et al. 2008

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A novel ruthenium(II)-complex containing 4-carboxy N-ethylbenzamide (Ru(II)-CNEB) was found to interact with and inhibit M4-lactate dehydrogenase (M4-LDH), a tumor growth supportive enzyme, at the tissue level. The present article describes modulation of M4-LDH by this compound in a T-cell lymphoma (Dalton's Lymphoma: DL) vis a vis regression of the tumor in vivo. The compound showed a dose dependent cytotoxicity to DL cells in vitro. When a non toxic dose (10 mg/kg bw i.p.) of Ru(II)-CNEB was administered to DL bearing mice, it also produced a significant decline in DL cell viability in vivo. The DL cells from Ru(II)-CNEB treated DL mice showed a significant decline in the level of M4-LDH with a concomitant release of this protein in the cell free ascitic fluid. A significant increase of nuclear DNA fragmentation in DL cells from Ru(II)-CNEB treated DL mice also coincided with the release of mitochondrial cytochrome c in those DL cells. Importantly, neither blood based biochemical markers of liver damage nor the normal patterns of LDH isozymes in other tissues were affected due to the treatment of DL mice with the compound. These results were also comparable with the effects of cisplatin (an anticancer drug) observed simultaneously on DL mice. The findings suggest that Ru(II)-CNEB is able to regress Dalton's lymphoma in vivo via declining M4-LDH and inducing mitochondrial dysfunction-apoptosis pathway without producing any toxicity to the normal tissues.

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Section: Discussionmentioning

confidence: 69%

Regression of Dalton’s lymphoma in vivo via decline in lactate dehydrogenase and induction of apoptosis by a ruthenium(II)-complex containing 4-carboxy N-ethylbenzamide as ligand

et al. 2008

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“…But this species was reported by the traditional healers of the current study area to treat tumor ( Tanachaa ). Root extracts of Withania somnifera (L.) Dun showed anticarcinogenic [38,39] and anti-stress activity [40]. The latter activity of this species validates its traditional use by the local healers of the study area to treat evil eye ( Buda ).…”

Section: Discussionmentioning

confidence: 82%

Traditional medicinal plant knowledge and use by local healers in Sekoru District, Jimma Zone, Southwestern Ethiopia

Yineger

Yewhalaw

2007

J Ethnobiology Ethnomedicine

234

146

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The knowledge and use of medicinal plant species by traditional healers was investigated in Sekoru District, Jimma Zone, Southwestern Ethiopia from December 2005 to November 2006. Traditional healers of the study area were selected randomly and interviewed with the help of translators to gather information on the knowledge and use of medicinal plants used as a remedy for human ailments in the study area. In the current study, it was reported that 27 plant species belonging to 27 genera and 18 families were commonly used to treat various human ailments. Most of these species (85.71%) were wild and harvested mainly for their leaves (64.52%). The most cited ethnomedicinal plant species was Alysicarpus quartinianus A. Rich., whose roots and leaves were reported by traditional healers to be crushed in fresh and applied as a lotion on the lesions of patients of Abiato (Shererit). No significant correlation was observed between the age of traditional healers and the number of species reported and the indigenous knowledge transfer was found to be similar. More than one medicinal plant species were used more frequently than the use of a single species for remedy preparations. Plant parts used for remedy preparations showed significant difference with medicinal plant species abundance in the study area.

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“…It is popularly known as Ashwagandha and its roots are important source of steroidal alkaloids and steroidal lactones (Qamar Uddin et al 2012). It grows profusely in India and other parts of the world, is used traditionally for anti-tumor activity, hepatoprotectiveness and anti-inflammatory activity (Christina et al 2004). The present study was designed to evaluate the As accumulation potential of Withania somnifera and to study ensuing physiological and biochemical changes of the plants.…”

Section: Introductionmentioning

confidence: 99%

Analysis of arsenic induced physiological and biochemical responses in a medicinal plant, Withania somnifera

Siddiqui

Tandon

Srivastava

2015

Physiol Mol Biol Plants

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Withania somnifera has been an important herb in the Ayurvedic and indigenous medical systems for centuries in India. However, these grow as weeds mostly in the wastelands, which receive contaminated water from municipal and industrial sources. In the present investigation, plants of Withania somnifera were exposed to various concentrations of arsenate (AsV) and arsenite (AsIII) (0, 10, 25, 50, 100 μM) for 10 days and analysed for accumulation of arsenic (As) and physiological and biochemical changes. Plants showed more As accumulation upon exposure to AsIII (320 μg g −1 DW in roots and 161 μg g −1 DW in leaves) than to AsV (173 μg g −1 DW in roots and 100 μg g −1 DW in leaves) after 10 days of treatment. Consequently, AsIII exposure caused more toxicity to plants as compared to that AsV, as evaluated in terms of the level of photosynthetic pigments and oxidative stress parameters (superoxide, hydrogen peroxide and lipid peroxidation), particularly at higher concentrations and on longer durations. Plants could tolerate low concentrations (variable for AsIII and AsV) until longer durations (10 days) and high concentrations for shorter durations (1-5 days) through increase in antioxidant enzymes and by augmented synthesis of thiols. In conclusion, As tolerance potential of Withania plants on one hand advocates its prospective use for remediation under proper supervision and on the other demonstrates possible threat of As entry into humans due to medicinal uses.

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Anticarcinogenic activity of Withania somnifera Dunal against Dalton’s Ascitic Lymphoma

Cited by 58 publications

References 8 publications

Regression of Dalton’s lymphoma in vivo via decline in lactate dehydrogenase and induction of apoptosis by a ruthenium(II)-complex containing 4-carboxy N-ethylbenzamide as ligand

Regression of Dalton’s lymphoma in vivo via decline in lactate dehydrogenase and induction of apoptosis by a ruthenium(II)-complex containing 4-carboxy N-ethylbenzamide as ligand

Traditional medicinal plant knowledge and use by local healers in Sekoru District, Jimma Zone, Southwestern Ethiopia

Analysis of arsenic induced physiological and biochemical responses in a medicinal plant, Withania somnifera

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