Anticarcinogenic Factors in Plant Foods: A New Class of Nutrients?

Evaluation of anti–apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide

“…Many antioxidants such as resveratrol found in grapes and other food products have anticancer or anti-carcinogenic properties along with the anti-apoptotic activity [6] . Furthermore, they can protect cells from oxidative damage and programmed cell death [7] .…”

Phytochemicals and cancer

“…This framework has been valuable for the development of research on the many different types of secondary plant metabolites that show biological activity in mammals (Johnson et al 1994), and it continues to provide a valuable approach to the classification of these compounds and their effects. A scheme for the interactions between blocking agents, suppressing agents and the generalised sequence for the onset of neoplasia is shown in Fig.…”

“…Some compounds that do exert anti-carcinogenic effects at realistic doses may contribute to the putative benefits of plant foods such as berries, brassica vegetables and tea, but further research with human subjects is required to fully confirm and quantify such benefits. Chemoprevention using pharmacological doses of isolated compounds, or the development of 'customised' vegetables, may prove valuable but such strategies require a full risk-benefit analysis based on a thorough understanding of the long-term biological effects of what are often surprisingly active compounds.Phytochemicals: Anti-carcinogenic activity: Molecular effects: Chemoprevention A review by the author and colleagues was published in 1994 (Johnson et al 1994) that explored the potential anticarcinogenic effects of a range of biologically-active secondary plant metabolites commonly present in human diets, and tentatively considered whether such compounds, now commonly referred to collectively as 'phytochemicals', might usefully be regarded as a new class of micronutrients. The interest in these compounds was stimulated partly by the work of pioneers in this field such as Wattenberg (1975a,b), who first demonstrated the principles of chemoprevention by plant constituents in animal models, and partly by the wealth of epidemiological evidence then emerging for protective effects of diets rich in fruits and vegetables against a variety of cancers (Block et al 1992).…”

“…Phytochemicals: Anti-carcinogenic activity: Molecular effects: Chemoprevention A review by the author and colleagues was published in 1994 (Johnson et al 1994) that explored the potential anticarcinogenic effects of a range of biologically-active secondary plant metabolites commonly present in human diets, and tentatively considered whether such compounds, now commonly referred to collectively as 'phytochemicals', might usefully be regarded as a new class of micronutrients. The interest in these compounds was stimulated partly by the work of pioneers in this field such as Wattenberg (1975a,b), who first demonstrated the principles of chemoprevention by plant constituents in animal models, and partly by the wealth of epidemiological evidence then emerging for protective effects of diets rich in fruits and vegetables against a variety of cancers (Block et al 1992).…”

Dietary Agents and Phytochemicals in the Prevention and Treatment of Hepatocellular Carcinoma: Review Article

“…100 The polyphenolic compound curcumin demonstrated similar profile to Epigallocatechin-3-gallate. 101 Various other studies also suggest chemopreventive potentials of phytochemicals compounds in hepatocellular carcinoma. Furthermore the supplementation with dietary phytochemicals may have potential therapeutic benefits in human subjects of liver HCC.…”