Anticarcinogenicity potential of spinasterol isolated from squash flowers

Villaseñor, Irene M.; Domingo, Annette P.

doi:10.1002/(sici)1520-6866(2000)20:3<99::aid-tcm1>3.0.co;2-7

Cited by 47 publications

(37 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Spinasterol has been reported in Cucurbita moschata (Rodriguez et al, 1996), Conyza blinii (Xu et al, 1998), Gypsophila oldhamiana (Yang et al, 1999), Gordonia ceylanica (Herath et al, 2001), and Acacia cedilloi (Pech et al, 2002). Recently, the anti-tumor activity of spinasterol was demonstrated in vivo in studies that showed that it greatly decreased the incidence of skin tumors without co-carcinogen or co-tumor promoter activities (Villasenor and Domingo, 2000). Little is known of spinasterol as a phytoestrogen other than that it exists and has anti-tumor activity.…”

Section: R Esults and Discussionmentioning

confidence: 99%

Antitumor activity of spinasterol isolated from Pueraria roots

Jeon

Park²,

Yoon³

et al. 2005

Exp Mol Med

View full text Add to dashboard Cite

Section: R Esults and Discussionmentioning

confidence: 99%

Antitumor activity of spinasterol isolated from Pueraria roots

Jeon

Park²,

Yoon³

et al. 2005

Exp Mol Med

View full text Add to dashboard Cite

“…Our experimental study proved the preventive effects of C. maxima seeds ME for hydatid cyst development. Although spinasterol is an active compound which isolated from flowers of C. maxima [19], further studies on probable other active compounds of C. maxima seeds ME to the determination of its mode of action on parasites are needed. Obviously, we demonstrated that C. maxima seeds ME (at 50 mg/ml concentration) exhibited a highly significant scolicidal and preventive activity in vitro and in vivo trials, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…C. maxima seeds with considerable safety margin versus commonly consumed chemical drugs (17), is a very rich in terms of amino acids that are building blocks of proteins, especially the essential amino acids such as phenylalanine and methionine which are not produced in the human body (18). Investigation on C. maxima (Squash) reported that spinasterol isolated from the flowers of C. maxima potentially showed anti-carcinogenic, anti-genotoxic (19), and anti-mutagenic activity (20). The C. maxima seeds were used in the treatment of digestive disorders [21], as well as essential oil of C. maxima seeds exhibited significant anti helmintic activity (16,18,22).…”

Section: Introductionmentioning

confidence: 99%

Cucurbita maxima (Pumpkin) seeds: Scolicidal activity and preventive efficacy of its extract on experimental hydatidosis in mice

Babaei

Jafari

Asadpour

et al. 2018

JBRMS

View full text Add to dashboard Cite

Introduction: Hydatid Disease (HD), a helminth infection with various clinical complications is a serious economic and public health concern around the world. Nowadays, different agents have been broadly applied as scolicids; these agents have several side effects on patients. Therefore, the aims of this experimental study were to evaluate the scolicidal activity of Cucurbita maxima seeds methanolic extract (ME) against protoscolices of hydatid cyst in-vitro. Also, an in vivo assay was designed to prove the preventive effects of the extract. Materials and methods: For this work, Two different concentrations (25 and 50 mg/ml) of the C. maxima seeds ME were used in various exposure times (10, 20, 30, 40, 50, and 60 min). Additionally, thirty mice were infected intraperitoneally by injection of 1000 viable protoscolices and were divided into three groups with ten mice in each Group I (treated by Albendazole), group II (received 50 mg/ml of C. maxima seeds ME) and group III (untreated controls). Results: Overall, C. maxima seeds ME exhibited significant scolicidal effects in compared with control group (P<0.05). At a concentration of 50 mg/ml, the mortality percentage increased to 84.7%, 96.1% and 100% after 40, 50 and 60 minutes, respectively. Also, the obtain data in necropsy demonstrated that C. maxima seeds ME have an inhibitory effect on the hydatid cyst development. No hydatid cyst formation observed in mice treated with C. maxima seeds ME (50 mg/ml) versus control group which hydatid cyst occurred in 6 (from 10) mice. Conclusion: The current investigation indicated that applying C. maxima seeds ME could be considered as a potential scolicidal agent due to being economical, safer and non-toxic compared to the reference chemical drugs. However, further studies on probably active compounds and also to the determination of its mode of action on parasites are required.

show abstract

“…Le potentiel antitumorigène du spinastérol a été démontré [36], tandis que le schotténol est un anticancérigène exprimant un potentiel cytotoxique prononcé [1].…”

Section: Pharmacologieunclassified