Anticardiolipin and acquired protein S deficiency in early childhood

Abstract

A 27 month old child presented with left hemiplegia and was found to have deep cerebral venous thrombosis. The deep cerebral venous thrombosis resolved on warfarin. Elevated and fluctuating anticardiolipin antibodies as well as protein S deficiency were detected.

Cerebral venous sinus thrombosis and thrombophilia presenting as pseudo-tumour syndrome following mild head injury

“…11 The presence of antiphospholipid antibodies alone may be insufficient to generate thrombosis; a "second hit", such as vascular stasis, vascular injury, oral contraceptives or risk factors for atherosclerosis may be required for thrombosis to occur. 7 The causative role of antiphospholipid antibodies in CVT has been well established in several studies, [13][14][15][16][17][18] which also showed that many patients with CVT have more than one causative factor. Thus, the identification of one cause for CVT does not abrogate the need to search for other potential causes.…”

An Atypical Case of Idiopathic Purpura Fulminans

“…[3][4][5] PF has also been associated with thrombophilic disorders, like antithrombin, anticardiolipin antibodies, or factor V Leiden (FVL) mutations. 2,[6][7][8][9] Given its association with disseminated intravascular coagulopathy and extensive skin necrosis, PF has a high rate of complications. Early recognition and rapid adequate management could prevent irreversible complications, including amputation and shock.…”

“…Nonbacterial PF has been described in the convalescence phase of a viral infection like varicella, herpesvirus-6, and group A Streptococcus pharyngitis or scarlet fever 3–5. PF has also been associated with thrombophilic disorders, like antithrombin, anticardiolipin antibodies, or factor V Leiden (FVL) mutations 2,6–9. Given its association with disseminated intravascular coagulopathy and extensive skin necrosis, PF has a high rate of complications.…”