Anticardiolipin antibodies and acute myocardial infarction in non-systemic lupus erythmatosus patients: A controlled prospective study

Zuckerman, Eli; Toubi, Elias; Shiran, Avinoam; Sabo, Edmund; Shmuel, Zehava; Golan, Theo Dov; Abinader, Edward G.; Yeshurun, Daniel

doi:10.1016/s0002-9343(96)00226-4

Cited by 85 publications

(53 citation statements)

References 26 publications

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“…Vol 46 No 4 In summary, this study shows for the first time that aCL positivity might be a risk factor for restenosis after PCI in ACS patients. The predictive value of these antibodies in ACS is too low and inconsistent for use in risk-stratification at this time.…”

Section: Discussionmentioning

confidence: 64%

“…Similar results were obtained by Cortellaro, et al 22) in their study of 74 young MI patients and Phadke, et al 5) who measured aCL in 299 survivors of acute MI. Zuckerman, et al 4) reported that the rates of thromboembolic events and myocardial reinfarction in patients with acute MI were significantly higher in aCL-positive patients than in the aCL negative group. The largest study on this issue was recently reported by Bili, et al 29) who studied 1150 AMI patients.…”

Section: Discussionmentioning

confidence: 99%

“…31) Studies indicate that aCL antibodies are not generated by tissue necrosis but rather that they participate in the pathogenesis of MI. 4,30) This hypothesis is biologically plausible because of the inflammatory 8,32,33) and procoagulant [34][35][36] properties of these antibodies.…”

Section: Discussionmentioning

confidence: 99%

“…Angiographic restenosis was defined as > 50% diameter stenosis within the target lesion. All patients underwent transthoracic echocardiography (TTE) and transesophageal echocardiography (TEE) using a HewlettPackard SONOS 5500 (Andover, Massachussetts) within 2 weeks of an acute Vol 46 No 4 event, when the patients were clinically stable. Left ventricular (LV) ejection fraction was determined from apical views using the modified Simpson's rule.…”

Section: Patientsmentioning

confidence: 99%

“…Zuckerman, et al 4) suggested that the presence of aCL is a marker for increased risk for myocardial reinfarction and thromboembolic events after acute myocardial infarction (MI). However, there have been many studies on myocardial infarction and coronary artery disease (CAD) in which the frequency of elevated aCL antibodies was not predictive of subsequent cardiovascular complications.…”

mentioning

confidence: 99%

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Association Between Anticardiolipin Antibodies and Recurrent Cardiac Events in Patients With Acute Coronary Syndrome

et al. 2005

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SUMMARYTo determine whether the presence of anticardiolipin (aCL) antibodies in patients with acute coronary syndome is predictive of recurrent cardiac events in hospital stay and follow-up.The study population consisted of 80 patients with acute coronary syndrome. IgM and IgG aCL levels were determined before hospital discharge. We divided the patients into those with an aCL IgG ≥ 40 IgG phospholipid units (group I, n = 30) and those with an aCL IgG < 40 IgG phospholipid units (group II, n = 50). All patients underwent coronary angiography. Follow-up coronary angiography was performed 12 months after percutaneous coronary intervention (PCI). Infectious and autoimmune diseases were exclusion criteria. Patients were observed to determine overall mortality, reinfarction, and restenosis.There were no differences between the groups with respect to the prevalence of hypertension, diabetes mellitus, and cigarette smoking, sex, or ejection fraction. The prevalence of left ventricular thrombus was similar between the groups (group I: 16% versus group II: 16.7%, P > 0.05). Although the presence of left atrial thrombus was much more frequent in cardiolipin positive patients (13% versus 4%, respectively), the difference was not statistically significant (P = 0.19). Restenosis was observed in 40% of the cardiolipin positive patients and 14% of the cardiolipin negative patients (P < 0.01). There was no significant association between reinfarction and anticardiolipin positivity during followup (26% versus 10%, P > 0.05). In group I patients, in-hospital mortality was somewhat more frequent compared to group II patients (4% versus 10%), but the difference was not statistically significant (P = 0.27). One year mortality was similar between the groups.These results suggest that 1) restenosis occurs more frequently in anticardiolipin positive patients and 2) no association is evident between positive aCL and mortality, reinfarction, and intracardiac thrombus. (Int Heart J 2005; 46: 631-638)

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Section: Discussionmentioning

confidence: 64%