Anticardiolipin antibodies in ectopic pregnancies

Jacob-Meisel, Margitta; Römer, Thomas; Straube, W; Meisel, Peter

doi:10.1016/s0301-2115(01)00360-8

Cited by 1 publication

(2 citation statements)

References 14 publications

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“…This is the first case report of childhood ischemic stroke with only anti-β2GPI, but no antibodies, detectable in standard antiphospholipid assays. determination of IgM may be a useful marker to discriminate ectopic pregnancies with autoimmune pathogenesis from those caused by other factors [71]. A study on 450 pregnant women with a history of one or more spontaneous abortions revealed that 72 (16%) of them were strongly positive for IgG aCL [72].…”

Section: Central Nervous System Manifestationsmentioning

confidence: 99%

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Some Recent Insights into the Prothrombogenic Mechanisms of Antiphospholipid Antibodies

Todorova¹,

Baleva

2007

CMC

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Antiphospholipid antibodies (aPL) are a heterogeneous group of autoantibodies, detected in the sera of patients with both autoimmune and various non-autoimmune diseases. They are also detected in subjects with no overt underlying disease - the primary antiphosphilipid syndrome (PAPS). High titers of APL are associated with arterial and venous thrombosis, recurrent fetal loss and thrombocytopenia. There have been many suggestions explaining the potential mechanisms of the procoagulant effect of aPL. These include endothelial cell (EC) activation; increased adhesion molecule expression; inhibition of EC prostacyclin release, increased leucocyte adhesion to EC, downregulation of thrombomodulin expression. APL induce the procoagulant activity of monocytes via increased tissue factor expression and directly stimulate platelet hyperactivity with resultant production of enhanced amounts of the proaggregatory molecule of TXA(2). In vitro studies show that prepro-endothelin-1 mRNA is induced by human monoclonal anticardiolipin antibodies and this might contribute to vasospasm, and, ultimately, to arterial occlusion. The hypercoagulable state in APS patients is associated with alterations in the protein C/S pathway. It is suggested that aPL may impair the protein C anticoagulant system. Acquired protein C and protein S deficiency is described in patients with APS. Beta2- glycoprotein I, (Beta2-GPI) a natural anticoagulant, is involved in the regulation of protein S anticoagulant activity by preventing the binding of protein S to C4b-binding protein. APL were shown to inhibit this effect of Beta2- GP I. As the group of aPL is very heterogeneous, it is unlikely that a single mechanism is responsible for the thrombogenic activity of all aPLs associated with thrombosis.

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Section: Central Nervous System Manifestationsmentioning

confidence: 99%

“…APL antibodies are a common finding in patients with recurrent fetal loss(es) [65][66][67][68][69][70][71]. Moreover, data show that the concerning the induction of aCL by sex hormones in normal subjects are scarce.…”

Section: Recurrent Fetal Lossmentioning

confidence: 99%

Some Recent Insights into the Prothrombogenic Mechanisms of Antiphospholipid Antibodies

Todorova¹,

Baleva

2007

CMC

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Anticardiolipin antibodies in ectopic pregnancies

Cited by 1 publication

References 14 publications

Some Recent Insights into the Prothrombogenic Mechanisms of Antiphospholipid Antibodies

Some Recent Insights into the Prothrombogenic Mechanisms of Antiphospholipid Antibodies

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