Anticardiolipin antibodies in the sera of patients with diagnosed chronic fatigue syndrome

Hokama, Y.; Campora, Cara Empey; Hara, Cynthia; Kuribayashi, T; Huynh, Diana; Yabusaki, Kenichi

doi:10.1002/jcla.20325

Cited by 26 publications

(16 citation statements)

References 13 publications

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“…Our observation is supported by a study that showed raised aCL IgG in young women aged between 36 and 37 years who had suffered ischemic stroke without having hypertension and hyperlipidemia (Cojocaru et al., 2007). Besides air pollution, chronic fatigue (Hokama et al., 2009) and mental health problems like schizophrenia can raise aCL level (Halacheva et al., 2009). Chronic fatigue in biomass‐using women is a distinct possibility, because they have the dual responsibility of fuel collection/preparation and cooking.…”

Section: Discussionmentioning

confidence: 99%

Hypertension with elevated levels of oxidized low-density lipoprotein and anticardiolipin antibody in the circulation of premenopausal Indian women chronically exposed to biomass smoke during cooking

et al. 2010

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The study showing high risk of developing cardiovascular diseases (CVD) among poor, underprivileged women in their reproductive ages in rural India is important from public health perspectives. It may motivate the government and the regulatory agencies of the country to take a serious note of the indoor air pollution (IAP) from biomass fuel use as it threatens the health of millions of women, children, and the elderly who mostly stay indoor. We hope the findings will strengthen the demand for setting up a standard for indoor air quality in the country in the line of national ambient air quality standard. The findings may also inspire the authorities to take measures for the reduction in IAP by improving housing, kitchen ventilation, and cook stoves. Moreover, the parameters used in this study can be utilized for large, population-based studies to identify women at a higher risk of developing CVD so that medical intervention can be taken at the formative stage of a disease.

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Section: Discussionmentioning

confidence: 99%

Hypertension with elevated levels of oxidized low-density lipoprotein and anticardiolipin antibody in the circulation of premenopausal Indian women chronically exposed to biomass smoke during cooking

et al. 2010

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“…The latter may cause mutagenic mtDNA lesions and accumulations of these lesions [19]. ME/CFS has been shown to be accompanied by mitochondrial damage [10,11,20,21] and mitochondrial dysfunctions and structural changes [22,23], which is important in that these mitochondrial and mtDNA lesions may cause lowered activity of the mitochondrial respiratory chain, which produces ATP and accounts for 98% of cellular energy [19]. …”

Section: Backgroiundmentioning

confidence: 99%

Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

Maes¹,

et al. 2011

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SummaryBackgroundThere is evidence that myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is characterized by activation of immune, inflammatory, oxidative and nitrosative stress (IO&NS) pathways. The present study was carried out in order to examine whether ME/CFS is accompanied by increased levels of plasma peroxides and serum oxidized LDL (oxLDL) antibodies, two biomarkers of oxidative stress.Material/MethodsBlood was collected from 56 patients with ME/CFS and 37 normal volunteers. Severity of ME/CFS was measured using the Fibromyalgia and Chronic Fatigue Syndrome (FF) Rating Scale.ResultsPlasma peroxide concentrations were significantly higher in patients with ME/CFS than in normal controls. There was a trend towards significantly higher serum oxLDL antibodies in ME/CFS than in controls. Both biomarkers contributed significantly in discriminating between patients with ME/CFS and normal controls. Plasma peroxide and serum oxLDL antibody levels were both significantly related to one of the FF symptoms.ConclusionsThe results show that ME/CFS is characterized by increased oxidative stress.

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“…Anti-cardiolipin antibodies have been documented in 95% of patients with CFS in one study 132. In CFS triggered by parvovirus B19, antinuclear antibody and RF were detectable in serum 133…”

Section: Autoimmune Diseases Associated With Parvovirus B19 Infectionmentioning

confidence: 90%

The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease

Kerr

2015

J Clin Pathol

108

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Human parvovirus B19 is a single-stranded DNA virus which preferentially targets the erythroblasts in the bone marrow. B19 infection commonly causes erythema infectiosum, arthralgia, fetal death, transient aplastic crisis in patients with shortened red cell survival, and persistent infection in people who are immunocompromised. Less common clinical manifestations include atypical skin rashes, neurological syndromes, cardiac syndromes, and various cytopenias. B19 infection has also been associated with development of a variety of different autoimmune diseases, including rheumatological, neurological, neuromuscular, cardiovascular, haematological, nephrological and metabolic. Production of a variety of autoantibodies has been demonstrated to occur during B19 infection and these have been shown to be key to the pathogenesis of the particular disease process in a significant number of cases, for example, production of rheumatoid factor in cases of B19-associated rheumatoid arthritis and production of anti-glutamic acid decarboxylase (GAD) in patients with B19-associated type 1 diabetes mellitus. B19 infection has also been associated with the development of multiple autoimmune diseases in 12 individuals. Documented mechanisms in B19-associated autoimmunity include molecular mimicry (IgG antibody to B19 proteins has been shown to cross react with a variety of recognised human autoantigens, including collagen II, keratin, angiotensin II type 1 receptor, myelin basic protein, cardiolipin, and platelet membrane glycoprotein IIb/IIIa), B19-induced apoptosis with presentation of self-antigens to T lymphocytes, and the phospholipase activity of the B19 unique VP1 protein.

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Anticardiolipin antibodies in the sera of patients with diagnosed chronic fatigue syndrome

Cited by 26 publications

References 13 publications

Hypertension with elevated levels of oxidized low-density lipoprotein and anticardiolipin antibody in the circulation of premenopausal Indian women chronically exposed to biomass smoke during cooking

Hypertension with elevated levels of oxidized low-density lipoprotein and anticardiolipin antibody in the circulation of premenopausal Indian women chronically exposed to biomass smoke during cooking

Increased plasma peroxides as a marker of oxidative stress in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease

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