Anticaries effect of low-fluoride dentifrices with phosphates in children: A randomized, controlled trial

Freire, Isabelle Rodrigues; Pessan, Juliano Pelim; Amaral, Jackeline Gallo do; Martinhon, Cleide Cristina Rodrigues; Cunha, Robson Frederico; Delbem, Alberto Carlos Botazzo

doi:10.1016/j.jdent.2016.04.013

Cited by 43 publications

(41 citation statements)

References 31 publications

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“…The ability of TMP to increase hydroxyapatite resistance to acid attack observed from the present results can be attributed to its capacity to adsorb to CHA, as previously suggested . The data from adsorption of TMP to CHA [Figure (g)] showed a dose‐response pattern and was influenced by presence of fluoride in the medium.…”

Section: Discussionsupporting

confidence: 83%

“…TMP is a cyclophosphate nominated more correctly as cyclotriphosphate. In vitro , in situ and clinical studies demonstrated that TMP‐containing fluoridated dentifrices, gels, mouthrinses and varnishes have a higher protective effect for both dental caries and erosion when compared with products without TMP. This cyclotriphosphate has also been used as a reagent for phosphorylation, as it induces calcium phosphate precipitation and proliferation of osteoblasts on collagen, and improves the integration of polymeric biomaterials with natural hard tissues .…”

Section: Introductionmentioning

confidence: 99%

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Cyclotriphosphate associated to fluoride increases hydroxyapatite resistance to acid attack

et al. 2018

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This study evaluated the effect of sodium trimetaphosphate (TMP) associated or not with fluoride (F) on the structure and dissolution of carbonated hydroxyapatite (CHA). Synthetic CHA powder (1.0 g) was suspended in solutions containing TMP at 0-10%, associated with 0, 1100, 4500, or 9000 ppm F, and the precipitates were submitted to a pH cycle (n = 6/group). Samples were analyzed by Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction. F, calcium (Ca) and phosphorous (P) concentrations were determined in CHA, while P and F were analyzed in the supernatants. Data were submitted to analysis of variance, Student-Newman-Keuls' test and Pearson's correlation coefficient (α = 0.05). Solutions containing 1100 ppm F with TMP between 2-4% and 4500 and 9000 ppm F with TMP between 4 and 8% led to higher Ca/P ratio (p < 0.05) in CHA. Alkali-soluble F deposition was directly related to TMP concentrations whereas an inverse pattern was observed for acid-soluble F incorporation (p < 0.05). Greater P adsorption in the CHA structure was observed with increasing concentrations of TMP for the 0 and 1100 ppm F solutions (p < 0.05). All diffractograms and FTIR spectra showed a similar pattern to that for pure hydroxyapatite. Thus, when TMP and F are coadministered, TMP interferes with F deposition on CHA, and an ideal TMP:F ratio can enhance the precipitation of CHA with lower solubility. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 2553-2564, 2018.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Cyclotriphosphate associated to fluoride increases hydroxyapatite resistance to acid attack

et al. 2018

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“…One way to reduce the potential risk of fluorosis while maintaining the anticaries efficacy of conventional dentifrices is to partly replace fluoride with polyphosphate salts like sodium trimetaphosphate (STMP), calcium glycerophosphate, or hexametaphosphate [da Camara et al, 2016;Takeshita et al, 2016;Zaze et al, 2014]. Among the polyphosphates, STMP is seen to be the most effective anticaries agent with an ability to not only inhibit demineralization, but also to enhance remineralization [Freire et al, 2016;Takeshita et al, 2011].…”

Section: Fluoride Boostersmentioning

confidence: 99%

“…While earlier clinical trials evaluating caries preventive effects of STMP produced conflicting results [O'Mullane et al, 1997;Stadtler et al, 1996], a recent 18-month double-blinded RCT showed that a 500-ppm low-fluoride dentifrice supplemented with STMP was significantly superior to a 1,100-ppm fluoride dentifrice in lowering the caries increment of children [Freire et al, 2016]. There is a need for additional clinical studies to ascertain whether STMP can influence the reversal of non-cavitated lesions.…”

Section: Fluoride Boostersmentioning

confidence: 99%

State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management

2018

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The principles of minimally invasive dentistry clearly dictate the need for clinically effective measures to remineralize early enamel caries lesions. While fluoride-mediated remineralization is the cornerstone of current caries management philosophies, a number of new remineralization strategies have been commercialized or are under development that claim to promote deeper remineralization of lesions, reduce the potential risks associated with high-fluoride oral care products, and facilitate caries control over a lifetime. These non-fluoride remineralizing systems can be broadly categorized into biomimetic enamel regenerative technologies and the approaches that repair caries lesions by enhancing fluoride efficacy. This paper discusses the rationale for non-fluoride remineralization and the mechanism of action, challenges, and evidence behind some of the most promising advances in enamel remineralization therapies.

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“…Sodium trimetaphosphate (TMP) is a condensed inorganic phosphate that was shown to increase the effects of a low-F toothpaste against enamel demineralization [Takeshita et al, 2009[Takeshita et al, , 2011Delbem et al, 2012;Takeshita et al, 2015] as well as to promote significantly lower caries increments in children when compared with a conventional (1,100 ppm F) toothpaste [Freire et al, 2016]. Although the effect of TMP upon an acid challenge is based on its capacity to adsorb on enamel and increase calcium, phosphate and fluoride incorporation [Takeshita et al, 2009[Takeshita et al, , 2011Delbem et al, 2012;Takeshita et al, 2015], few data are available on the effects of TMP on enamel remineralization.…”

mentioning

confidence: 99%

Remineralizing Potential of a Low Fluoride Toothpaste with Sodium Trimetaphosphate: An in situ Study

Takeshita

Danelon²,

Castro³

et al. 2016

Caries Res

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Objective: To evaluate the effect of a low-fluoride (F) toothpaste supplemented with sodium trimetaphosphate (TMP) on enamel remineralization in situ. Design: Bovine enamel blocks were selected on the basis of their surface hardness (SH) after caries-like lesions had been induced, and randomly divided into 4 treatment groups, according to the toothpastes used: without F or TMP (placebo); 500 ppm F; 500 ppm F plus 1% TMP; and 1,100 ppm F. The study design was blinded and crossover and performed in 4 phases of 3 days each. Eleven subjects used palatal appliances containing 4 bovine enamel blocks which were treated 3 times per day during 1 min each time, with natural slurries of saliva and toothpaste formed in the oral cavity during toothbrushing. After each phase, the percentages of surface (%SH_R) and subsurface hardness recovery (%ΔKHN_R) were calculated. F, calcium (Ca), and phosphorus (Pi) contents in enamel were also determined. Data were analyzed by 1-way, repeated-measures ANOVA, followed by the Student-Newman-Keuls test (p < 0.05). Results: Toothpaste with 500 ppm F + TMP and 1,100 ppm F showed similar %SH_R and %ΔKHN_R as well as enamel F, Ca, and Pi concentrations. Conclusion: The addition of TMP to a low-fluoride toothpaste promoted a similar remineralizing capacity to that of a standard (1,100 ppm F) toothpaste in situ.

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Anticaries effect of low-fluoride dentifrices with phosphates in children: A randomized, controlled trial

Cited by 43 publications

References 31 publications

Cyclotriphosphate associated to fluoride increases hydroxyapatite resistance to acid attack

Cyclotriphosphate associated to fluoride increases hydroxyapatite resistance to acid attack

State of the Art Enamel Remineralization Systems: The Next Frontier in Caries Management

Remineralizing Potential of a Low Fluoride Toothpaste with Sodium Trimetaphosphate: An in situ Study

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