Anticentromere antibody: an immunological marker of a subset of systemic sclerosis

Chorzelski, Tadeusz P.; Jabłońska, Stefania; Beutner, Ernst H.; Błaszczyk, M; Jarzabek-Chorzelska, M; Kencka, D.; Krasny, Susan A.; Kumar, Vijay; Tchorzewska, A. T.

doi:10.1111/j.1365-2133.1985.tb02351.x

Cited by 34 publications

(5 citation statements)

References 22 publications

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“…If patients are classified according to the varieties of systemic sclerosis and presence or absence of Scl 70 antibody, slight differences can be seen (Tables 4 and 5). There were no -In this group only cases negative for ACA are included; cases positive for ACA have been described in detail previously (Chorzelski et al, 1985). Some indurations and/or atrophy, mainly on the thorax.…”

Section: Resultsmentioning

confidence: 99%

“…In contrast to ACA antibody, which is a marker of an abortive subset of acrosclerosis with almost no cutaneous indurations (Chorzelski et al, 1985), Scl 70 is a marker of systemic sclerosis as a whole, with prevalence in diffuse scleroderma, but present also in a high proportion of cases of acrosclerosis. Thus, it does not discriminate between the subsets of systemic scleroderma.…”

Section: Discussionmentioning

confidence: 96%

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Scl 70 antibody—a specific marker of systemic sclerosis

Jarzabek-Chorzelska¹,

Błaszczyk²,

Jabłońska³

et al. 1986

Br J Dermatol

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Scl 70 antibodies were tested for in 107 patients with systemic sclerosis: 68 with acrosclerosis and 39 with diffuse scleroderma. Anticentromere antibodies (ACA) and other antinuclear antibodies (ANA) were tested for by indirect immunofluorescence on HEp-2 cells. Positive results for Scl 70 antibodies were obtained in 77% of cases of diffuse scleroderma and 44% of acrosclerosis. ACA and Scl 70 antibodies were found to be mutually exclusive. If acrosclerosis cases positive for anticentromere antibodies are excluded, the percentage of acrosclerosis cases positive for Scl 70 was 63%. ACA were found to be a marker of a benign, abortive subset of acrosclerosis with almost no cutaneous involvement (CREST), whereas Scl 70 did not discriminate between acrosclerosis and diffuse scleroderma. On HEp-2 cells Scl 70 positive sera gave a characteristic, fine speckled, almost homogeneous nuclear staining pattern.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 96%

Scl 70 antibody—a specific marker of systemic sclerosis

Jarzabek-Chorzelska¹,

Błaszczyk²,

Jabłońska³

et al. 1986

Br J Dermatol

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“…Contrary to adult SSc, in which ACA (15,23, Btaszczyk et al: Immunologic Markers of SSc 19 25,30,31) is an immunologic marker of limited scleroderma with induration confined to the digits, until now this antibody has not been detected in childhood SSc. In limited scleroderma confined to digits, somewhat simitar to CREST in adults, we found Scl-70 antibody in children, and in one of four it coexisted with ACA.…”

Section: Discussionmentioning

confidence: 99%

Immunologic Markers of Systemic Scleroderma in Children

Błaszczyk¹,

Jabfołnska²,

Szymańska-Jagiello³

et al. 1991

Pediatric Dermatology

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This study was performed on seven children with systemic scleroderma, three with the diffuse and four with the limited type. All three patients with diffuse scleroderma had high titers of clumpy pattern antinucleolar antibody on HEp-2 cells. The course of the disease was severe, and two children died. Four children with limited scleroderma had mild disease, and Scl-70 antibody, an immunologic marker that in adults is associated mostly with diffuse scleroderma. In one child Scl-70 antibody and anticentromere antibody coexisted, although previously the two were believed to be mutually exclusive. This study shows that limited scleroderma of childhood with slight cutaneous involvement may be associated with the Scl-70 marker. The findings in 10 adults in whom Raynaud's phenomenon developed in childhood and indurations appeared some years later, point to the significance of careful observation of these children, with repeated testing for immunologic markers of SSc. An important new finding is the association of different types of systemic sclerodermas with specific immunologic markers.

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“…Three additional autoantibodies have important diagnostic value. Anti‐centromere antibodies are characteristic of CREST syndrome, 18,37 which has a better prognosis than PSS. Scl‐70 antibodies are directed against the enzyme topoisomerase‐I 38 and are associated with PSS 18,39 , 40 .…”

Section: Specific Antibodies and Associated Diseasesmentioning

confidence: 99%