Anticentromere Antibody and Immunoglobulin Allotypes in Scleroderma

Chen, Zeyi

doi:10.1001/archderm.1985.01660030061019

Cited by 14 publications

(3 citation statements)

References 28 publications

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“…We also found that the Gm(1,3,17;5,21) phenotype was increased in SLE and MCTD patients compared with controls, but these differences were not statistically significant. We failed to identify any association of Gm or Km phenotypes with scleroderma, which was similar to the results in 3 previously published studies on that disease (23)(24)(25).…”

Section: Discussionsupporting

confidence: 89%

Association of immunoglobulin Km and Gm allotypes with specific antinuclear antibodies and disease susceptibility among connective tissue disease patients

Hoffman

Sharp

Irvin

et al. 1991

Arthritis & Rheumatism

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The distribution of the immunoglobulin Km( 1) and Gm phenotypes was examined in patients with connective tissue diseases, including systemic lupus erythematosus, mixed connective tissue disease, and scleroderma, whose sera were characterized for antibodies against nuclear antigens and polypeptides of U small nuclear ribonucleoproteins. We found a strong association between the Km(1) phenotype and susceptibility to systemic lupus erythematosus (P < 0.00001, relative risk = 17). We also found a positive association between the Km(1) phenotype and the presence of anti-double-stranded DNA antibodies. The presence of

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Section: Discussionsupporting

confidence: 89%

Association of immunoglobulin Km and Gm allotypes with specific antinuclear antibodies and disease susceptibility among connective tissue disease patients

Hoffman

Sharp

Irvin

et al. 1991

Arthritis & Rheumatism

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“…Our finding of no association between GM/KM phenotypes and SSc is consistent with the results of previous studies [4,9,10]. In this regard, the role of Ig allotypes in the pathogenesis of SSc appears to be similar to that of HLA antigens in that neither genetic system is strongly associated with the disease itself, but contributes significantly to the generation of particular autoimmune responses [2,4].…”

Section: Discussionsupporting

confidence: 92%

Anti-Fibrillin-1 Autoantibodies in Systemic Sclerosis Are GM and KM Allotype-Restricted

Pandey¹,

Page

Silver

et al. 2001

Exp Clin Immunogenet

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GM and KM allotypes – genetic markers of immunoglobulin (Ig) γ and ĸ chains, respectively – have been shown to play an important role in genetic predisposition to some autoimmune diseases. To determine their role in susceptibility to systemic sclerosis (SSc; scleroderma) and in the generation of anti-fibrillin-1 antibodies, 148 SSc patients and 191 controls were typed for several GM and KM allotypes by a standard hemagglutination inhibition method. IgG and IgM antibodies to fibrillin-1 were measured by radioimmunoassay. GM and KM phenotypes were not significantly associated with SSc. However, these determinants significantly influenced the production of anti-fibrillin-1 antibodies in SSc patients. In Caucasians, GM1,3,17 23 5,13,21 and GM3 23 5,13 phenotypes were associated with the presence and absence of IgG autoantibodies, respectively. The production of these autoantibodies was also associated with KM allotypes, KM1,3 heterozygosity being associated with response and homozygosity for the KM3 allele with nonresponse to fibrillin-1. In African-Americans, the KM1 homozygotes were associated with the absence of anti-fibrillin-1 antibodies and the KM3 homozygotes with the presence of autoantibodies. In this ethnic group, the GM1,17 5,13 phenotype was associated with the absence of IgM autoantibodies. This represents the first description of genetic control of autoimmunity to fibrillin-1 in scleroderma.

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“…13 One of the authors (JPP) previously showed the lack of associations between serologically determined GM/KM phenotypes and ACA 26. The reasons for this discordant result are unclear; possible explanations include patient selection methods and ethnic backgrounds of SSc patients studied.…”

Section: Discussionmentioning

confidence: 99%

Immunoglobulin allotype gene polymorphisms in systemic sclerosis: interactive effect of MHC class II and KM genes on anticentromere antibody production

Kameda

Pandey

Kaburaki

et al. 1998

Annals of the Rheumatic Diseases

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Anticentromere Antibody and Immunoglobulin Allotypes in Scleroderma

Cited by 14 publications

References 28 publications

Association of immunoglobulin Km and Gm allotypes with specific antinuclear antibodies and disease susceptibility among connective tissue disease patients

Association of immunoglobulin Km and Gm allotypes with specific antinuclear antibodies and disease susceptibility among connective tissue disease patients

Anti-Fibrillin-1 Autoantibodies in Systemic Sclerosis Are GM and KM Allotype-Restricted

Immunoglobulin allotype gene polymorphisms in systemic sclerosis: interactive effect of MHC class II and KM genes on anticentromere antibody production

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