Anticholinergic Action of Paeony Root and Its Active Constituents

Ueda, Chiaki; Aoki, Shunji; Tajima, Kiyoko; Tanaka, Naomi; Yamahara, Johji

doi:10.1248/yakushi1947.110.12_964

Cited by 25 publications

(11 citation statements)

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“…[13][14][15][16] The causes behind such irregular absorption may be related to the physicochemical properties of the molecule, involving a very slow dissolution rate in the gastrointestinal fluid, 13) or to the anticholinergic properties of the drug, which may become more evident during prolonged treatment, modifying the gastrointestinal transit time. In contrast, PR has been found to exhibit an anticholinergic effect, 17) which might affect gastric emptying and theoretically lead to delayed absorption of CBZ. The present results shown faster absorption of CBZ when coadministered with PR.…”

Section: Resultsmentioning

confidence: 99%

Pharmacokinetic Interactions between Carbamazepine and the Traditional Chinese Medicine Paeoniae Radix.

Chen

Chen²,

Chou³

et al. 2002

Biological & Pharmaceutical Bulletin

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The present study was conducted to evaluate the effects of Paeoniae Radix (PR), one of the most famous tonic traditional Chinese medicines, on the pharmacokinetics of carbamazepine (CBZ) in rats and to determine the possible interactions between PR and CBZ. The significant decrease in T max indicated that simultaneous oral administration of PR contributed to more rapid absorption of CBZ. It is suggested that the faster absorption of CBZ might lead to the rapid onset of its clinical effect. There were no significant differences in maximum concentration (C max ), area under the plasma concentration-time curve (AUC), half-life (t 1/2 ), mean residence time (MRT), clearance/bioavailability (CL/F), and apparent volume of distribution/bioavailability (V d /F) of CBZ between the two groups, showing that PR did not significantly affect the absorption extent, distribution, metabolism, and elimination of CBZ. A significant decrease in protein binding rate was found when CBZ was coadministered with PR. Further studies are in progress to clarify the clinical significance and the mechanism underlying the effects of PR on the protein binding of CBZ observed in the present study.

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Section: Resultsmentioning

confidence: 99%

Pharmacokinetic Interactions between Carbamazepine and the Traditional Chinese Medicine Paeoniae Radix.

Chen

Chen²,

Chou³

et al. 2002

Biological & Pharmaceutical Bulletin

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“…In addition to glycyrrhizin, there are many other active components contained in Si-Ni-San. For instance, saikosaponins from Radix Bupleuri were well known to have excellent anti-inflammatory activity [36]; paeoniflorin from Radix Paeoniae showed a potent analgesic action [37]; and naringin from Fructus Citri Aurantii had antioxidant effects in cholesterol-fed rabbits [38]. All these findings as well as those on the biological activities of glycyrrhizin so far, were obtained by pharmacological assays using the purified compounds.…”

Section: Discussionmentioning

confidence: 99%

Selective depletion of glycyrrhizin from Si-Ni-San, a traditional Chinese prescription, blocks its effect on contact sensitivity in mice and recovers adhesion and metalloproteinases production of T lymphocytes

Zhang

Sun

Chen

et al. 2005

International Immunopharmacology

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In the present study, we performed to selectively deplete glycyrrhizin from Si-Ni-San, a traditional Chinese prescription that consists of 4 Chinese herbs including Radix Glycyrrhizae Uralensis, and examined its influence on the suppressing activity of Si-Ni-San against contact sensitivity in mice. An immunoaffinity column was made by covalently coupling the polyclonal antibody, obtained by the immunization with glycyrrhizin-BSA conjugate, to CNBr-activated Sepharose 4B. By using this column, glycyrrhizin in Si-Ni-San was selectively and almost completely depleted from the whole extract, which was confirmed by high-performance liquid chromatography (HPLC). Both 200 mg/kg of Si-Ni-San and 10 mg/kg of glycyrrhizin, the dose corresponding to its proportion contained in Si-Ni-San, significantly reduced the ear swelling of picryl chloride (PCl)-induced ear contact sensitivity in mice and the inhibition by Si-Ni-San was stronger than that by glycyrrhizin. The adhesion activity to type IV collagen of the isolated spleen cells from PCl-sensitized mice was significantly decreased by both Si-Ni-San and glycyrrhizin. However, the glycyrrhizin-depleted sample of Si-Ni-San (Si-Ni-San(GL-)) only showed a slight inhibition on the cell adhesion. Furthermore, the spleen cells from PCl-sensitized mice produced more matrix metalloproteinase (MMP)-2 and -9 than naive spleen cells did, and both Si-Ni-San and glycyrrhizin remarkably reduced MMP-2 and MMP-9 production. In contrast, Si-Ni-San(GL-) only showed a slight inhibition. These results suggest that glycyrrhizin may act as one of the active constituents of Si-Ni-San in inhibiting delayed-type hypersensitivity reaction via down-regulating the MMP production and the cell adhesion to extracellular matrix. The present study also provides a new approach to recognize and validate an active constituent in traditional prescription through a selective depletion.

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“…1H) is the major active component [1][2][3]. Paeoniflorin (C 23 H 28 O 11 , with a molecular weight of 480.45) is a water-soluble monoterpene glycoside, the content of which constitutes>90% of TGP and 0.05-6.01% of Radix Paeoniae Alba.…”

Section: O M / L O C a T E / I N T I M Pmentioning

confidence: 99%

“…Furthermore, intra-gastric administration of TGP was demonstrated to increase the threshold of feeling the pain in mice [8]. Anticholinergic action may be responsible for the analgesic effect of TGP [3]. Recently, it was demonstrated that intraperitoneal injection of paeoniflorin, a chief active ingredient in Radix Paeoniae, is effective in relieving visceral pain, which is mediated, at least in part, by adenosine A1 receptors [10].…”

Section: Analgesic Effectsmentioning

confidence: 99%

Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis

Zhang

Dai

2012

International Immunopharmacology

131

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Anticholinergic Action of Paeony Root and Its Active Constituents

Cited by 25 publications

References 0 publications

Pharmacokinetic Interactions between Carbamazepine and the Traditional Chinese Medicine Paeoniae Radix.

Pharmacokinetic Interactions between Carbamazepine and the Traditional Chinese Medicine Paeoniae Radix.

Selective depletion of glycyrrhizin from Si-Ni-San, a traditional Chinese prescription, blocks its effect on contact sensitivity in mice and recovers adhesion and metalloproteinases production of T lymphocytes

Mechanisms involved in the therapeutic effects of Paeonia lactiflora Pallas in rheumatoid arthritis

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