Anticholinergic, antidiabetic and antioxidant activities of cinnamon (
            <i>cinnamomum verum</i>
            ) bark extracts: polyphenol contents analysis by LC-MS/MS

Gülçın, İlhami; Kaya, Rüya; Gören, Ahmet; Akıncıoğlu, Hülya; Topal, Meryem; Bingöl, Zeynebe; Çakmak, Kader Cetin; Sarıkaya, Sevim Beyza Öztürk; Durmaz, Lokman; Alwasel, Saleh

doi:10.1080/10942912.2019.1656232

Cited by 131 publications

(76 citation statements)

References 100 publications

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“…The essential oil of this herb has been shown to have antioxidant activity. Other studies have reported antioxidant activities of water, methanol, and ethanolic cinnamon extracts [ 45 , 46 , 136 , 137 , 138 ]. This plant shows high anti-influenza virus activity [ 139 ].…”

Section: Antimicrobial Agentmentioning

confidence: 99%

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

et al. 2020

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Recently, increasing public concern about hygiene has been driving many studies to investigate antimicrobial and antiviral agents. However, the use of any antimicrobial agents must be limited due to their possible toxic or harmful effects. In recent years, due to previous antibiotics’ lesser side effects, the use of herbal materials instead of synthetic or chemical drugs is increasing. Herbal materials are found in medicines. Herbs can be used in the form of plant extracts or as their active components. Furthermore, most of the world’s populations used herbal materials due to their strong antimicrobial properties and primary healthcare benefits. For example, herbs are an excellent material to replace nanosilver as an antibiotic and antiviral agent. The use of nanosilver involves an ROS-mediated mechanism that might lead to oxidative stress-related cancer, cytotoxicity, and heart diseases. Oxidative stress further leads to increased ROS production and also delays the cellular processes involved in wound healing. Therefore, existing antibiotic drugs can be replaced with biomaterials such as herbal medicine with high antimicrobial, antiviral, and antioxidant activity. This review paper highlights the antibacterial, antiviral, and radical scavenger (antioxidant) properties of herbal materials. Antimicrobial activity, radical scavenger ability, the potential for antimicrobial, antiviral, and anticancer agents, and efficacy in eliminating bacteria and viruses and scavenging free radicals in herbal materials are discussed in this review. The presented herbal antimicrobial agents in this review include clove, portulaca, tribulus, eryngium, cinnamon, turmeric, ginger, thyme, pennyroyal, mint, fennel, chamomile, burdock, eucalyptus, primrose, lemon balm, mallow, and garlic, which are all summarized.

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Section: Antimicrobial Agentmentioning

confidence: 99%

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

et al. 2020

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“…Cinnamomum zeylanicum also known as cinnamon has been used for medicine and as an ingredient in Asian food. The oil extracted from Cinnamomum zeylanicum showed antioxidant, antifungal, anticancer, anti-inflammatory, antidiabetes, and antihypertensive capabilities in the previous reports (Nyadjeu et al, 2011;Varalakshmi et al, 2014;Han and Parker, 2017;Gulcin et al, 2019). It is well documented that an active constituent in a plant is varied on the method of extraction.…”

Section: Resultsmentioning

confidence: 85%

Determination of Antioxidant, Anti-Aging and Cytotoxicity Activity of the Essential Oils From Cinnamomum Zeylanicum

Wanakhachornkrai¹,

Banglao²,

Thongmee³

et al. 2020

J microb biotech food sci

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Antioxidant activity, anti-aging effects and cytotoxicity activity of cinnamon essential oils from Cinnamomum zeylanicum were investigated in this study. The antioxidant activities of the cinnamon essential oil at the concentrations of 125, 250, 500, and 1000 µg/mL were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2ʹ-azino-bis (3-ethylbenzo-thiazoline-6-sulfonic acid) diammonium salt (ABTS). The inhibitory activities against collagenase, elastase and tyrosinase were evaluated for anti-aging effects. The antioxidant activity determined by DPPH and ABTS assays varied from 4.91 - 28.74% and 4.96 - 50.17%, respectively. In addition, cinnamon essential oil at all concentrations tested (100, 200, 500, and 1000 µg/mL) inhibited tyrosinase activity by 61.68 - 93.12 %, collagenase activity by 2.83 - 30.28 % and elastase activity by 4.37 - 33.92 %. The cytotoxicity activity determined by the diphenyltetrazolium (MTT) assay revealed that the cinnamon essential oil at the concentration less than 100 µg/mL did not exhibit cytotoxicity activity on human fibroblast cells while the percentage of cell viability decreased when exposed to this oil at the concentration higher than 150 µg/mL. These results demonstrated that the cinnamon essential oil has antioxidant, tyrosinase inhibitory, collagenase inhibitory, and elastase inhibitory activities. In addition, cinnamon essential oil at each effective concentration did not show any toxicity when tested on normal human fibroblast cell. Therefore, this essential oil could be a potential candidate for cosmetic and pharmaceutical products.

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“…The breakdown of these substrates was monitored spectrophotometrically by yellow color formation of 5‐thio‐2‐nitrobenzoate anion as the result of the reaction of DTNB with thiocholine from hydrolysis of AChI or BChI with absorption at a wavelength of 412 nm. [ 52,53 ]…”

Section: Methodsmentioning

confidence: 99%

Synthesis and in silico studies of triazene‐substituted sulfamerazine derivatives as acetylcholinesterase and carbonic anhydrases inhibitors

Bilginer

Gül

Anil

et al. 2020

Archiv der Pharmazie

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A novel series of sulfonamides, 4‐(3‐phenyltriaz‐1‐en‐1‐yl)‐N‐(4‐methyl‐2‐pyrimidinyl)benzenesulfonamides (1–9), was designed and synthesized by the diazo reaction between sulfamerazine and substituted aromatic amines for the first time. Their chemical structures were characterized by 1H nuclear magnetic resonance (NMR), 13C NMR, and high‐resolution mass spectra. The newly synthesized compounds were evaluated in terms of acetylcholineasterase (AChE) and human carbonic anhydrases (hCA) I and II isoenzymes inhibitory activities. According to the AChE inhibition results, the Ki values of the compounds 1–9 were in the range of 19.9 ± 1.5 to 96.5 ± 20.7 nM against AChE. Tacrine was used as the reference drug and its Ki value was 49.2 ± 2.7 nM against AChE. The Ki values of the compounds 1–9 were in the range of 10.2 ± 2.6 to 101.4 ± 27.8 nM against hCA I, whereas they were 18.3 ± 4.4 to 48.1 ± 4.5 nM against hCA II. Acetazolamide was used as a reference drug and its Ki values were 72.2 ± 5.4 and 52.2 ± 5.7 nM against hCA I and hCA II, respectively. The most active compounds, 1 (nonsubstituted) against AChE, 5 (4‐ethoxy‐substituted) against hCA I, and 8 (4‐bromo‐substituted) against hCA II, were chosen and docked at the binding sites of these enzymes to explain the inhibitory activities of the series. The newly synthesized compounds presented satisfactory pharmacokinetic properties via the estimation of ADME properties.

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Anticholinergic, antidiabetic and antioxidant activities of cinnamon ( cinnamomum verum ) bark extracts: polyphenol contents analysis by LC-MS/MS

Cited by 131 publications

References 100 publications

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

Antioxidant, Antimicrobial and Antiviral Properties of Herbal Materials

Determination of Antioxidant, Anti-Aging and Cytotoxicity Activity of the Essential Oils From Cinnamomum Zeylanicum

Synthesis and in silico studies of triazene‐substituted sulfamerazine derivatives as acetylcholinesterase and carbonic anhydrases inhibitors

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