Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS

Kızıltaş, Hatice; Gören, Ahmet; Bingöl, Zeynebe; Alwasel, Saleh; Gülçın, İlhami

doi:10.25135/rnp.236.21.02.1983

Cited by 35 publications

(21 citation statements)

References 49 publications

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“…[29][30][31] DM has become a chronic metabolic disorder that has become a rapidly increasing epidemic in some countries of the world due to the increase in the aging population and inadequate health services. [32][33][34] However, it is well known that carbohydrate-related enzyme inhibitors such as α-glycosidase (α-Gly) by delaying glucose absorption such as acarbose (ACR), voglibose, and miglitol are some of the most effective control methods to overcome postprandial hyperglycemia. The α-Gly inhibitors have a large drug potential.…”

Section: Introductionmentioning

confidence: 99%

Benzimidazolium salts bearing the trifluoromethyl group as organofluorine compounds: Synthesis, characterization, crystal structure, in silico study, and inhibitory profiles against acetylcholinesterase and α‐glycosidase

Tezcan

Gök

Sevinçek

et al. 2022

J Biochem & Molecular Tox

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Here, we report the synthesis, characterization, and biological activities of a series of benzimidazolium salts bearing the trifluoromethylbenzyl group. All benzimidazolium salts were characterized by using nuclear magnetic resonance (NMR) ( 1 H NMR and 13 C NMR), Fourier transform-infrared spectroscopy, and elemental analysis techniques. The crystal structures of some of these compounds were obtained by the single-crystal X-ray diffraction method. Furthermore, the acetylcholinesterase (AChE) and α-glycosidase (α-Gly) enzyme inhibition activities of these compounds were investigated. The obtained results revealed that 2e, with K i value of 1.36 ± 0.34 µM against AChE and 3d with K i value of 91.37 ± 10.38 µM against α-Gly, were the most potent compounds against both assigned enzymes. It should be noted that most of the synthesized compounds were more potent than standard inhibitor tacrine (TAC) against AChE. In silico studies, we focused on compound 2e, 3d, 3e, and 3f as potent inhibitors of AChE and α-Gly, the compound 2e showed good binding energy (−10.23 kcal/mol), among the three selected compounds and positive control (−10.18, −10.08, and −7.37 kcal/mol for 3d, 3f, and TAC, respectively). Likewise, as a result of the same compounds against the α-Gly enzyme, the compound 3d had the highest binding affinity (−8.39 kcal/mol) between the four selected compounds and the positive control (−8.27, −8.10, −8.06, and −7.53 kcal/mol for 3f, 3e, 2e, and acarbose, respectively). From the absorption, distribution, metabolism, excretion, and toxicity analyses, it can be concluded that the compounds under consideration exhibited more drug-likeness properties in the prediction studies compared to positive controls.

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Section: Introductionmentioning

confidence: 99%

Benzimidazolium salts bearing the trifluoromethyl group as organofluorine compounds: Synthesis, characterization, crystal structure, in silico study, and inhibitory profiles against acetylcholinesterase and α‐glycosidase

Tezcan

Gök

Sevinçek

et al. 2022

J Biochem & Molecular Tox

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“…To determine the ABTS radical scavenging effects of EDOA and EDOR, the method in a prior study was used [ 58 ]. For determination of ABTS +• scavenging effects of EDOA and EDOR, the previously given method was used [ 59 , 60 , 61 ]. First, 2.45 mM persulfate solution was added to 2 mM ABTS solution to generate ABTS radicals.…”

Section: Methodsmentioning

confidence: 99%

Sahlep (Dactylorhiza osmanica): Phytochemical Analyses by LC-HRMS, Molecular Docking, Antioxidant Activity, and Enzyme Inhibition Profiles

et al. 2022

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Studies have shown an inverse correlation among age-related illnesses like coronary heart disease and cancer and intake of fruit and vegetable. Given the probable health benefits of natural antioxidants from plants, research on them has increased. Dactylorhiza osmanica is consumed as a food and traditional medicine plant in some regions of Turkey, so evaluation of the biological ability of this species is important. In this study, the amount of phenolic content (LC-HRMS), antioxidant activities and enzyme inhibitory properties of an endemic plant, D. osmanica, were investigated. The antioxidant capacities of an ethanol extract of D. osmanica aerial parts (EDOA) and roots (EDOR) were evaluated with various antioxidant methods. Additionally, the enzyme inhibitory effects of EDOA and EDOR were examined against acetylcholinesterase (AChE), α-glycosidase, and α-amylase enzymes, which are associated with common and global Alzheimer’s disease and diabetes mellitus. The IC50 values of EDOA against the enzymes were found to be 1.809, 1.098, and 0.726 mg/mL, respectively; and the IC50 values of EDOR against the enzymes were found to be 2.466, 0.442, and 0.415 mg/mL, respectively. Additionally, LC-HRMS analyses revealed p-Coumaric acid as the most plentiful phenolic in both EDOA (541.49 mg/g) and EDOR (559.22 mg/g). Furthermore, the molecular docking interaction of p-coumaric acid, quercitrin, and vanillic acid, which are the most plentiful phenolic compounds in the extracts, with AChE, α-glucosidase, and α-amylase, were evaluated using AutoDock Vina software. The rich phenolic content and the effective antioxidant ability and enzyme inhibition potentials of EDOA and EDOR may support the plant’s widespread food and traditional medicinal uses.

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“…Aloe, 59 mint, 60 banaba, 61 bitter melon, 62 caper bush, 63 cinnamon, 64 cocoa, 65 coffee, 66 fenugreek, 67 garlic, 68 guava, 69 turmeric, 70 tea, 71 walnuts, 72 Shaggy bindweed, 73 Yerba mates , 74 Bambusa tulda , 75 Ficus bengalensis , 76 Ferula orientalis, 77 Gymnema sylvestre , 78 Dioscorea japonica , 79 Artemisia abyssinica , 80 Phaseolus vulgaris , 81 Datura quercifolia , 82 Cassia fistula , 83 Citrus aurantium , 84 Ficus benghalensis , 85 Polygonum aviculare , 86 Allium tuncelianum , 87 Astragalus brachycalyx , 88 Ferulago stelleta , 89 and Rhizophora mucronate 90 are natural sources that contain chemical moieties which are effective against diabetes. 91 However, recent research-based studies showed more aim to develop new drugs that can be provided orally for the therapeutics uses of diabetes disease.…”

Section: Diabetes Mellitusmentioning

confidence: 99%

Heterocyclic compounds as a magic bullet for diabetes mellitus: a review

Farwa

Raza

2022

RSC Adv.

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Anticholinergic, Antidiabetic and Antioxidant Activities of Ferula orientalis L. Determination of Its Polyphenol Contents by LC-HRMS

Cited by 35 publications

References 49 publications

Benzimidazolium salts bearing the trifluoromethyl group as organofluorine compounds: Synthesis, characterization, crystal structure, in silico study, and inhibitory profiles against acetylcholinesterase and α‐glycosidase

Benzimidazolium salts bearing the trifluoromethyl group as organofluorine compounds: Synthesis, characterization, crystal structure, in silico study, and inhibitory profiles against acetylcholinesterase and α‐glycosidase

Sahlep (Dactylorhiza osmanica): Phytochemical Analyses by LC-HRMS, Molecular Docking, Antioxidant Activity, and Enzyme Inhibition Profiles

Heterocyclic compounds as a magic bullet for diabetes mellitus: a review

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