2015
DOI: 10.1186/s12877-015-0029-9
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Anticholinergic burden quantified by anticholinergic risk scales and adverse outcomes in older people: a systematic review

Abstract: BackgroundThe cumulative effect of taking multiple medicines with anticholinergic properties termed as anticholinergic burden can adversely impact cognition, physical function and increase the risk of mortality. Expert opinion derived risk scales are routinely used in research and clinical practice to quantify anticholinergic burden. These scales rank the anticholinergic activity of medicines into four categories, ranging from no anticholinergic activity (= 0) to definite/high anticholinergic activity (= 3). T… Show more

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Cited by 409 publications
(459 citation statements)
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“…Provided a patient is made aware of all material risks and reasonable alternatives then a prescriber is likely to satisfy the test for informed consent. While prescribers have access to a variety of tools to support safe deprescribing, [12][13][14][15][16] and alternative treatments are available for many conditions, the challenge is how we identify risks that are material to our patients. Patientcentred conversations 17 in the context of structured review 18 may support embedding this in our daily practice.…”
Section: Resultsmentioning
confidence: 99%
“…Provided a patient is made aware of all material risks and reasonable alternatives then a prescriber is likely to satisfy the test for informed consent. While prescribers have access to a variety of tools to support safe deprescribing, [12][13][14][15][16] and alternative treatments are available for many conditions, the challenge is how we identify risks that are material to our patients. Patientcentred conversations 17 in the context of structured review 18 may support embedding this in our daily practice.…”
Section: Resultsmentioning
confidence: 99%
“…44,45 Both these drugs have strong anticholinergic activity, as rated on anticholinergic risk scales, 39,[43][44][45][46] and are typical drugs that may be used long-term by patients. The relationship of anticholinergic drugs, the parasympathetic nervous system, and the enteric nervous system is shown in Fig.…”
Section: Anticholinergic Drugsmentioning
confidence: 99%
“…A supratherapeutic concentration was then added, allowed to equilibrate for 5 minutes, and then recorded for 5 minutes. 46 Wong et al…”
Section: Anticholinergic Drugsmentioning
confidence: 99%
“…al. 27 , e pesquisouse também a presença do fármaco na lista de medicamentos de alta atividade anticolinérgica incluída nos Critérios de Beers 28 . As informações sobre as reações adversas a medicamentos e outros aspectos relacionados à segurança foram pesquisados na bula versão para o paciente.…”
Section: Metodologiaunclassified