Anticholinergic drugs versus non-drug active therapies for overactive bladder syndrome in adults

Alhasso, Ammar; McKinlay, Jayne A C; Patrick, Kate; Stewart, Lawrence H.

doi:10.1002/14651858.cd003193.pub3

Cited by 94 publications

(60 citation statements)

References 42 publications

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“…A comparison of the incidence of AEs with the two doses of solifenacin could be calculated for weeks [8][9][10][11][12][13][14][15][16]. With solifenacin alone, the incidence of treatment-related AEs was 2.4% with the 5 mg and 13.4% with the 10 mg dose.…”

Section: The Study Period Was May 2006 To May 2007mentioning

confidence: 99%

“…Currently, few clinical studies have evaluated the efficacy of antimuscarinic therapy combined with bladder training [8]. The objective of the SOLAR (SOLifenacin Alone and with simplified bladder Re-training) study was to compare the efficacy of flexible dosing with solifenacin 5/10 mg with and without simplified bladder training in a randomized, 16-week, open-label study.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of simplified bladder training in patients with overactive bladder receiving a solifenacin flexible‐dose regimen: results from a randomized study

Mattiasson¹,

Masala²,

Morton

et al. 2010

BJU International

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Study Type – Therapy (RCT) Level of Evidence 1bOBJECTIVETo compare the efficacy of flexible‐dose solifenacin 5/10 mg with and without simplified bladder training in patients with overactive bladder (OAB) syndrome.PATIENTS AND METHODSSOLAR (SOLifenacin Alone and with simplified bladder Re‐training) was a multicentre, prospective, randomized, parallel‐group, open‐label study in patients with OAB. After a 2‐week, single‐blind, placebo run‐in, 643 patients were randomized to treatment with either solifenacin 5 mg once daily (od) alone (323) or 5 mg od combined with simplified bladder training (320) for 8 weeks. At week 8, patients in both groups could request a dose increase to solifenacin 10 mg od for the remaining 8 weeks of the study. The primary efficacy endpoint was the change from baseline in the mean number of micturitions/24 h after 8 weeks. Secondary efficacy measures were the change in micturition frequency and other voiding diary variables at week 16. Patient‐reported outcomes were also assessed, including patient Perception of Bladder Condition, Incontinence Quality of Life, and Treatment Satisfaction using a visual analogue scale score; tolerability was also assessed.RESULTSSolifenacin given alone was effective in improving all measures of OAB evaluated in the study. When simplified bladder training was used combined with solifenacin there was a further significant improvement in micturition frequency at week 8, and this difference was maintained through to week 16. The use of simplified bladder training with solifenacin also significantly improved treatment satisfaction at week 16 over the responses to solifenacin given alone. There was no significant difference between the treatment groups at week 16 in urgency, incontinence or other secondary variables measured. The most common adverse event reported was dry mouth in both treatment groups; there was a low rate of discontinuation due to adverse events in the total study group.CONCLUSIONCombined treatment with solifenacin and simplified bladder training was more effective than solifenacin alone in reducing micturition frequency at weeks 8 and 16, and improving treatment satisfaction at week 16 in patients with OAB. Simplified bladder training did not improve on the benefits of solifenacin alone in the symptoms of urgency or incontinence.

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Section: The Study Period Was May 2006 To May 2007mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of simplified bladder training in patients with overactive bladder receiving a solifenacin flexible‐dose regimen: results from a randomized study

Mattiasson¹,

Masala²,

Morton

et al. 2010

BJU International

View full text Add to dashboard Cite

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“…Another Cochrane review provided evidence that treatment with antimuscarinic medications provided more symptomatic improvement than bladder training. 54 The combination of antimuscarinics and bladder training was also associated with more improvement than bladder training alone. Similarly, the limited data favored a combination of antimuscarinics with bladder training compared with antimuscarinics, although the difference was not statistically significant.…”

Section: Outcomes After Treatment With Muscarinic Receptor Antagonistsmentioning

confidence: 99%

Update on the management of overactive bladder: patient considerations and adherence

Dmochowski¹,

Gomelsky²

2010

RRU

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Overactive bladder (OAB) is a common condition that causes a profound impact on an individual's overall health and quality of life. Muscarinic receptor antagonists are the mainstay of oral pharmacotherapy for OAB. Although all of the medications in this class are significantly more effective than placebo, they are also associated with more adverse events that may limit their overall use. Although newer preparations of these medications have sought to improve tolerability and efficacy through alternative routes of delivery and once-daily dosing, improved adherence to treatment and treatment persistence continue to be an ongoing challenge. An improved understanding of the factors involved in persistence of medical OAB therapy is imperative in efforts to optimize therapeutic benefits in this chronic and potentially morbid condition.

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“…Moreover, injection of onabotulinumtoxinA into detrusor is another modality. Selection of a specific modality is based on the severity of signs and symptoms, and the resulted complications affect the patients' quality of life (16). The three main treatment modalities are drug therapy, behavioral therapy, and surgery (17).…”

Section: Introductionmentioning

confidence: 99%

Comparing the Effect of Tolterodine, Biofeedback (Pelvic Floor Muscles Training) and Drug plus Biofeedback on Quality of Life and Urge Urinary Incontinency in Patients Referred to Imam Khomeini Hospital in 2014

Pasikhani¹,

Ghanbari²,

Khatibi³

et al. 2016

J Obstet Gynecol Cancer Res

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Background: Urgency is a characteristic for overactive bladder and is defined by a sudden obligatory need for urination, a feeling that can be hardly stopped. Many methods such as drug therapy and feedback have been used to treat urinary incontinency. Objectives: The aim of this study was to assess and compare the effect of medication, biofeedback or biofeedback plus medication on urge-urinary incontinency and quality of life of patients. Methods: This was a case-control randomized clinical trial performed on patients referred to Imam Khomeini hospital in 2014. Patients were divided into three groups of drug (Tolterodine), biofeedback, and biofeedback plus drug. Biofeedback group underwent two sessions of treatment weekly for four weeks, and the drug group received tolterodine (4 mg slow release) for four weeks. The third group received both of them. Quality of life and urinary incontinency symptoms were compared between the three groups and analyzed, using SPSS Version 16 software (IBM, Armonk, USA). Results: Meaningful differences were observed between the three groups with respect to change in the total score of the questionnaire (P < 0.001). Between the groups, drug therapy had the most effect on improving the total score of the questionnaire, with a

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Anticholinergic drugs versus non-drug active therapies for overactive bladder syndrome in adults

Cited by 94 publications

References 42 publications

Efficacy of simplified bladder training in patients with overactive bladder receiving a solifenacin flexible‐dose regimen: results from a randomized study

Efficacy of simplified bladder training in patients with overactive bladder receiving a solifenacin flexible‐dose regimen: results from a randomized study

Update on the management of overactive bladder: patient considerations and adherence

Comparing the Effect of Tolterodine, Biofeedback (Pelvic Floor Muscles Training) and Drug plus Biofeedback on Quality of Life and Urge Urinary Incontinency in Patients Referred to Imam Khomeini Hospital in 2014

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