Anticholinergic Exposure, Drug Dose and Postoperative Delirium: Comparison of Dose-Related and Non-Dose-Related Anticholinergic Burden Scores in a Retrospective Cohort Study of Older Orthopaedic and Trauma Surgery Patients
Carolin Geßele,
Constanze Rémi,
Vera Smolka
et al.
Abstract:Purpose
Postoperative delirium (POD) is a common complication in older adult patients after surgery. A patient’s preoperative anticholinergic (AC) burden is a potentially modifiable risk factor for POD. As the influence of the drug dose remains unknown, we aimed to compare three AC burden scores in relation to POD, two of which were dose-related.
Methods
This retrospective cohort study (03/22–10/22) included orthopaedic and trauma surgery patients > 65 years. POD was as… Show more
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